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Preparation and properties of nano-hydroxyapatite/PCL-PEG-PCL composite membranes for tissue engineering applications.

Abstract

Nano-hydroxyapatite (n-HA)/poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) composite membranes were prepared by solvent casting and evaporation method. The structure and properties of the membranes were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), water contact angle measurements, in vitro hydrolytic degradation, mechanical test, and cell culture. The effect of n-HA content on physical-chemical properties of the n-HA/PCEC composite membranes was studied. The results showed that the shape and size of micropores of the composite membranes changed with n-HA content increased; the tensile strength decreased with the increase of n-HA content. The osteoblast cell was cultured on the membranes, good cell attachment and growth manner were observed after postseeding for 1 day. MTT assays showed that the n-HA/PCEC membranes had no negative effect on the cell viability and proliferation. These results suggested that the obtained n-HA/PCEC composite membranes in this study might have prospective applications in tissue engineering field.

Authors+Show Affiliations

State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21290585

Citation

Fu, Shao Zhi, et al. "Preparation and Properties of nano-hydroxyapatite/PCL-PEG-PCL Composite Membranes for Tissue Engineering Applications." Journal of Biomedical Materials Research. Part B, Applied Biomaterials, vol. 97, no. 1, 2011, pp. 74-83.
Fu SZ, Wang XH, Guo G, et al. Preparation and properties of nano-hydroxyapatite/PCL-PEG-PCL composite membranes for tissue engineering applications. J Biomed Mater Res Part B Appl Biomater. 2011;97(1):74-83.
Fu, S. Z., Wang, X. H., Guo, G., Shi, S., Fan, M., Liang, H., ... Qian, Z. Y. (2011). Preparation and properties of nano-hydroxyapatite/PCL-PEG-PCL composite membranes for tissue engineering applications. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 97(1), pp. 74-83. doi:10.1002/jbm.b.31788.
Fu SZ, et al. Preparation and Properties of nano-hydroxyapatite/PCL-PEG-PCL Composite Membranes for Tissue Engineering Applications. J Biomed Mater Res Part B Appl Biomater. 2011;97(1):74-83. PubMed PMID: 21290585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and properties of nano-hydroxyapatite/PCL-PEG-PCL composite membranes for tissue engineering applications. AU - Fu,Shao Zhi, AU - Wang,Xiu Hong, AU - Guo,Gang, AU - Shi,Shuai, AU - Fan,Min, AU - Liang,Hang, AU - Luo,Feng, AU - Qian,Zhi Yong, Y1 - 2011/02/02/ PY - 2010/07/15/received PY - 2010/09/26/revised PY - 2010/10/25/accepted PY - 2011/2/4/entrez PY - 2011/2/4/pubmed PY - 2011/6/18/medline SP - 74 EP - 83 JF - Journal of biomedical materials research. Part B, Applied biomaterials JO - J. Biomed. Mater. Res. Part B Appl. Biomater. VL - 97 IS - 1 N2 - Nano-hydroxyapatite (n-HA)/poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) composite membranes were prepared by solvent casting and evaporation method. The structure and properties of the membranes were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), water contact angle measurements, in vitro hydrolytic degradation, mechanical test, and cell culture. The effect of n-HA content on physical-chemical properties of the n-HA/PCEC composite membranes was studied. The results showed that the shape and size of micropores of the composite membranes changed with n-HA content increased; the tensile strength decreased with the increase of n-HA content. The osteoblast cell was cultured on the membranes, good cell attachment and growth manner were observed after postseeding for 1 day. MTT assays showed that the n-HA/PCEC membranes had no negative effect on the cell viability and proliferation. These results suggested that the obtained n-HA/PCEC composite membranes in this study might have prospective applications in tissue engineering field. SN - 1552-4981 UR - https://www.unboundmedicine.com/medline/citation/21290585/Preparation_and_properties_of_nano_hydroxyapatite/PCL_PEG_PCL_composite_membranes_for_tissue_engineering_applications_ L2 - https://doi.org/10.1002/jbm.b.31788 DB - PRIME DP - Unbound Medicine ER -