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Comparing the efficacy of α-glucosidase inhibitors in suppressing postprandial hyperglycemia using continuous glucose monitoring: a pilot study-the MAJOR study.
Diabetes Technol Ther. 2011 Mar; 13(3):303-8.DT

Abstract

BACKGROUND

This study aimed to compare glucose variability in patients given the α-glucosidase inhibitors miglitol and acarbose using continuous glucose monitoring (CGM).

METHODS

Ten type 2 diabetes patients were hospitalized for 4 days, and their glucose levels were measured using CGM. Patients were given miglitol (50 mg) or acarbose (100 mg) before each meal on Day 2, and vice versa on Day 3, in a randomized crossover design. The patients had three identical test meals on Days 2 and 3. The CGM data were used to compare each parameter for glycemic variability after each of the three meals.

RESULTS

No significant differences were observed between miglitol treatment or acarbose treatment in regard to the range of increase in glucose levels from baseline to peak, time to peak postprandial glucose levels from the preprandial period, and area under the curve for glycemic variability from the preprandial period to 3 h after each meal. However, the range of increase in glucose levels at 30 min (0.4 vs. 30.7 mg/dL, P < 0.0001) and 60 min (32.8 vs. 67.5 mg/dL, P <0.0001) after lunch and 30, 60, and 90 min after dinner (3.3 vs. 22.2 mg/dL, P = 0.0249; 36.6 vs. 67.5 mg/dL, P < 0.0001; and 60.5 vs. 81.6 mg/dL, P = 0.0073, respectively) was significantly smaller in miglitol treatment compared with acarbose treatment.

CONCLUSIONS

In a pilot study with a crossover design in 10 type 2 diabetes patients, it was shown that although there was no significant difference in glucose variability with miglitol or acarbose after a fat-rich diet, glucose increases was significantly reduced with miglitol after a meal comprising typical Japanese diet 60-90 min postprandially.

Authors+Show Affiliations

Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. dtsujino@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21291335

Citation

Tsujino, Daisuke, et al. "Comparing the Efficacy of Α-glucosidase Inhibitors in Suppressing Postprandial Hyperglycemia Using Continuous Glucose Monitoring: a Pilot Study-the MAJOR Study." Diabetes Technology & Therapeutics, vol. 13, no. 3, 2011, pp. 303-8.
Tsujino D, Nishimura R, Taki K, et al. Comparing the efficacy of α-glucosidase inhibitors in suppressing postprandial hyperglycemia using continuous glucose monitoring: a pilot study-the MAJOR study. Diabetes Technol Ther. 2011;13(3):303-8.
Tsujino, D., Nishimura, R., Taki, K., Morimoto, A., Tajima, N., & Utsunomiya, K. (2011). Comparing the efficacy of α-glucosidase inhibitors in suppressing postprandial hyperglycemia using continuous glucose monitoring: a pilot study-the MAJOR study. Diabetes Technology & Therapeutics, 13(3), 303-8. https://doi.org/10.1089/dia.2010.0099
Tsujino D, et al. Comparing the Efficacy of Α-glucosidase Inhibitors in Suppressing Postprandial Hyperglycemia Using Continuous Glucose Monitoring: a Pilot Study-the MAJOR Study. Diabetes Technol Ther. 2011;13(3):303-8. PubMed PMID: 21291335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparing the efficacy of α-glucosidase inhibitors in suppressing postprandial hyperglycemia using continuous glucose monitoring: a pilot study-the MAJOR study. AU - Tsujino,Daisuke, AU - Nishimura,Rimei, AU - Taki,Kentaro, AU - Morimoto,Aya, AU - Tajima,Naoko, AU - Utsunomiya,Kazunori, Y1 - 2011/02/03/ PY - 2011/2/5/entrez PY - 2011/2/5/pubmed PY - 2011/7/2/medline SP - 303 EP - 8 JF - Diabetes technology & therapeutics JO - Diabetes Technol Ther VL - 13 IS - 3 N2 - BACKGROUND: This study aimed to compare glucose variability in patients given the α-glucosidase inhibitors miglitol and acarbose using continuous glucose monitoring (CGM). METHODS: Ten type 2 diabetes patients were hospitalized for 4 days, and their glucose levels were measured using CGM. Patients were given miglitol (50 mg) or acarbose (100 mg) before each meal on Day 2, and vice versa on Day 3, in a randomized crossover design. The patients had three identical test meals on Days 2 and 3. The CGM data were used to compare each parameter for glycemic variability after each of the three meals. RESULTS: No significant differences were observed between miglitol treatment or acarbose treatment in regard to the range of increase in glucose levels from baseline to peak, time to peak postprandial glucose levels from the preprandial period, and area under the curve for glycemic variability from the preprandial period to 3 h after each meal. However, the range of increase in glucose levels at 30 min (0.4 vs. 30.7 mg/dL, P < 0.0001) and 60 min (32.8 vs. 67.5 mg/dL, P <0.0001) after lunch and 30, 60, and 90 min after dinner (3.3 vs. 22.2 mg/dL, P = 0.0249; 36.6 vs. 67.5 mg/dL, P < 0.0001; and 60.5 vs. 81.6 mg/dL, P = 0.0073, respectively) was significantly smaller in miglitol treatment compared with acarbose treatment. CONCLUSIONS: In a pilot study with a crossover design in 10 type 2 diabetes patients, it was shown that although there was no significant difference in glucose variability with miglitol or acarbose after a fat-rich diet, glucose increases was significantly reduced with miglitol after a meal comprising typical Japanese diet 60-90 min postprandially. SN - 1557-8593 UR - https://www.unboundmedicine.com/medline/citation/21291335/Comparing_the_efficacy_of_α_glucosidase_inhibitors_in_suppressing_postprandial_hyperglycemia_using_continuous_glucose_monitoring:_a_pilot_study_the_MAJOR_study_ L2 - https://www.liebertpub.com/doi/10.1089/dia.2010.0099?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -