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Endoscopic radiofrequency ablation combined with endoscopic resection for early neoplasia in Barrett's esophagus longer than 10 cm.
Gastrointest Endosc. 2011 Apr; 73(4):682-90.GE

Abstract

BACKGROUND

Radiofrequency ablation (RFA) is safe and effective for eradicating Barrett's esophagus (BE) and BE-associated early neoplasia. Most RFA studies have limited the baseline length of BE (<10 cm), and therefore little is known about RFA for longer BE.

OBJECTIVE

To assess the safety and efficacy of RFA with or without prior endoscopic resection (ER) for BE ≥ 10 cm containing neoplasia.

DESIGN

Prospective trial.

SETTING

Two tertiary-care centers.

PATIENTS

This study involved consecutive patients with BE ≥ 10 cm with early neoplasia.

INTERVENTION

Focal ER for visible abnormalities, followed by a maximum of 2 circumferential and 3 focal RFA procedures every 2 to 3 months until complete remission.

MAIN OUTCOME MEASUREMENTS

Complete remission, defined as endoscopic resolution of BE and no intestinal metaplasia (CR-IM) or neoplasia (CR-neoplasia) in biopsy specimens.

RESULTS

Of the 26 patients included, 18 underwent ER for visible abnormalities before RFA. The ER specimens showed early cancer in 11, high-grade intraepithelial neoplasia (HGIN) in 6, and low-grade intraepithelial neoplasia (LGIN) in 1. The worst residual histology, before RFA and after any ER, was HGIN in 16 patients and LGIN in 10 patients. CR-neoplasia and CR-IM were achieved in 83% (95% confidence interval [CI], 63%-95%) and 79% (95% CI, 58%-93%), respectively. None of the patients had fatal or severe complications and 15% (95% CI, 4%-35%) had moderate complications. During a mean (± standard deviation) follow-up of 29 (± 9.1) months, no neoplasia recurred.

LIMITATIONS

Tertiary-care center, short follow-up.

CONCLUSION

ER for visible abnormalities, followed by RFA of residual BE is a safe and effective treatment for BE ≥ 10 cm containing neoplasia, with a low chance of recurrence of neoplasia or BE during follow-up.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21292262

Citation

Alvarez Herrero, Lorenza, et al. "Endoscopic Radiofrequency Ablation Combined With Endoscopic Resection for Early Neoplasia in Barrett's Esophagus Longer Than 10 Cm." Gastrointestinal Endoscopy, vol. 73, no. 4, 2011, pp. 682-90.
Alvarez Herrero L, van Vilsteren FG, Pouw RE, et al. Endoscopic radiofrequency ablation combined with endoscopic resection for early neoplasia in Barrett's esophagus longer than 10 cm. Gastrointest Endosc. 2011;73(4):682-90.
Alvarez Herrero, L., van Vilsteren, F. G., Pouw, R. E., ten Kate, F. J., Visser, M., Seldenrijk, C. A., van Berge Henegouwen, M. I., Fockens, P., Weusten, B. L., & Bergman, J. J. (2011). Endoscopic radiofrequency ablation combined with endoscopic resection for early neoplasia in Barrett's esophagus longer than 10 cm. Gastrointestinal Endoscopy, 73(4), 682-90. https://doi.org/10.1016/j.gie.2010.11.016
Alvarez Herrero L, et al. Endoscopic Radiofrequency Ablation Combined With Endoscopic Resection for Early Neoplasia in Barrett's Esophagus Longer Than 10 Cm. Gastrointest Endosc. 2011;73(4):682-90. PubMed PMID: 21292262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endoscopic radiofrequency ablation combined with endoscopic resection for early neoplasia in Barrett's esophagus longer than 10 cm. AU - Alvarez Herrero,Lorenza, AU - van Vilsteren,Frederike G I, AU - Pouw,Roos E, AU - ten Kate,Fiebo J W, AU - Visser,Mike, AU - Seldenrijk,Cornelis A, AU - van Berge Henegouwen,Mark I, AU - Fockens,Paul, AU - Weusten,Bas L A M, AU - Bergman,Jaques J G H M, Y1 - 2011/02/02/ PY - 2010/09/14/received PY - 2010/11/08/accepted PY - 2011/2/5/entrez PY - 2011/2/5/pubmed PY - 2011/8/17/medline SP - 682 EP - 90 JF - Gastrointestinal endoscopy JO - Gastrointest. Endosc. VL - 73 IS - 4 N2 - BACKGROUND: Radiofrequency ablation (RFA) is safe and effective for eradicating Barrett's esophagus (BE) and BE-associated early neoplasia. Most RFA studies have limited the baseline length of BE (<10 cm), and therefore little is known about RFA for longer BE. OBJECTIVE: To assess the safety and efficacy of RFA with or without prior endoscopic resection (ER) for BE ≥ 10 cm containing neoplasia. DESIGN: Prospective trial. SETTING: Two tertiary-care centers. PATIENTS: This study involved consecutive patients with BE ≥ 10 cm with early neoplasia. INTERVENTION: Focal ER for visible abnormalities, followed by a maximum of 2 circumferential and 3 focal RFA procedures every 2 to 3 months until complete remission. MAIN OUTCOME MEASUREMENTS: Complete remission, defined as endoscopic resolution of BE and no intestinal metaplasia (CR-IM) or neoplasia (CR-neoplasia) in biopsy specimens. RESULTS: Of the 26 patients included, 18 underwent ER for visible abnormalities before RFA. The ER specimens showed early cancer in 11, high-grade intraepithelial neoplasia (HGIN) in 6, and low-grade intraepithelial neoplasia (LGIN) in 1. The worst residual histology, before RFA and after any ER, was HGIN in 16 patients and LGIN in 10 patients. CR-neoplasia and CR-IM were achieved in 83% (95% confidence interval [CI], 63%-95%) and 79% (95% CI, 58%-93%), respectively. None of the patients had fatal or severe complications and 15% (95% CI, 4%-35%) had moderate complications. During a mean (± standard deviation) follow-up of 29 (± 9.1) months, no neoplasia recurred. LIMITATIONS: Tertiary-care center, short follow-up. CONCLUSION: ER for visible abnormalities, followed by RFA of residual BE is a safe and effective treatment for BE ≥ 10 cm containing neoplasia, with a low chance of recurrence of neoplasia or BE during follow-up. SN - 1097-6779 UR - https://www.unboundmedicine.com/medline/citation/21292262/Endoscopic_radiofrequency_ablation_combined_with_endoscopic_resection_for_early_neoplasia_in_Barrett's_esophagus_longer_than_10_cm_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5107(10)02323-0 DB - PRIME DP - Unbound Medicine ER -