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Gluten-dependent enteropathy and atypical human leukocyte antigen alleles.
Hum Pathol 2011; 42(8):1112-6HP

Abstract

The risk for developing celiac disease is associated with the major histocompatibility complex class II human leukocyte antigen DQ2 and DQ8. We retrospectively reviewed the medical records of 127 consecutive cases of adult-onset celiac disease evaluated at a single United States center to determine the distribution of the associated human leukocyte antigen DQA1 and DQB1 alleles. The median patient age of diagnosis was 41 (range, 16-81) years. Ninety-five adults underwent human leukocyte antigen DQ typing. Eighty patients were DQ2 positive, 24 were DQ8 positive, and 11 were DQ2 and DQ8 positive. Four patients carried the uncommon, low-risk haplotype DQ2.2 (DQA1*02 and DQB1*02) without DQA1*05. Two patients did not carry human leukocyte antigen DQ2 or DQ8. All of the patients with atypical human leukocyte antigen DQ responded to a gluten-free diet. Although the majority of patients carry the human leukocyte antigen DQ2 or DQ8, gluten-dependent enteropathy periodically presents in adults with low-risk alleles.

Authors+Show Affiliations

Department of Medicine, Division of Gastroenterology, University of California, San Diego, La Jolla, CA 92093, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21292306

Citation

Harmon, Gregory S., et al. "Gluten-dependent Enteropathy and Atypical Human Leukocyte Antigen Alleles." Human Pathology, vol. 42, no. 8, 2011, pp. 1112-6.
Harmon GS, Lebeck LK, Weidner N. Gluten-dependent enteropathy and atypical human leukocyte antigen alleles. Hum Pathol. 2011;42(8):1112-6.
Harmon, G. S., Lebeck, L. K., & Weidner, N. (2011). Gluten-dependent enteropathy and atypical human leukocyte antigen alleles. Human Pathology, 42(8), pp. 1112-6. doi:10.1016/j.humpath.2010.10.010.
Harmon GS, Lebeck LK, Weidner N. Gluten-dependent Enteropathy and Atypical Human Leukocyte Antigen Alleles. Hum Pathol. 2011;42(8):1112-6. PubMed PMID: 21292306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gluten-dependent enteropathy and atypical human leukocyte antigen alleles. AU - Harmon,Gregory S, AU - Lebeck,Lauralynn K, AU - Weidner,Noel, Y1 - 2011/02/02/ PY - 2010/09/08/received PY - 2010/10/25/revised PY - 2010/10/27/accepted PY - 2011/2/5/entrez PY - 2011/2/5/pubmed PY - 2011/9/14/medline SP - 1112 EP - 6 JF - Human pathology JO - Hum. Pathol. VL - 42 IS - 8 N2 - The risk for developing celiac disease is associated with the major histocompatibility complex class II human leukocyte antigen DQ2 and DQ8. We retrospectively reviewed the medical records of 127 consecutive cases of adult-onset celiac disease evaluated at a single United States center to determine the distribution of the associated human leukocyte antigen DQA1 and DQB1 alleles. The median patient age of diagnosis was 41 (range, 16-81) years. Ninety-five adults underwent human leukocyte antigen DQ typing. Eighty patients were DQ2 positive, 24 were DQ8 positive, and 11 were DQ2 and DQ8 positive. Four patients carried the uncommon, low-risk haplotype DQ2.2 (DQA1*02 and DQB1*02) without DQA1*05. Two patients did not carry human leukocyte antigen DQ2 or DQ8. All of the patients with atypical human leukocyte antigen DQ responded to a gluten-free diet. Although the majority of patients carry the human leukocyte antigen DQ2 or DQ8, gluten-dependent enteropathy periodically presents in adults with low-risk alleles. SN - 1532-8392 UR - https://www.unboundmedicine.com/medline/citation/21292306/Gluten_dependent_enteropathy_and_atypical_human_leukocyte_antigen_alleles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(10)00391-6 DB - PRIME DP - Unbound Medicine ER -