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In vitro antiperoxidative, free radical scavenging and xanthine oxidase inhibitory potentials of ethyl acetate fraction of Saraca ashoka flowers.

Abstract

Saraca ashoka is a widely used medicinal herb claimed to cure many diseases. This study investigated the antiperoxidative, free radical scavenging and xanthine oxidase (XO) inhibitory potential of the ethyl acetate fraction of S. ashoka flowers (SAF) and compared it with standard compounds like gallic acid, ascorbic acid, butylated hydroxyl toluene and allopurinol. The ethyl acetate fraction of SAF exhibited free radical scavenging activity against the 1,1-diphenyl-2-picrylhydrazyl radical and superoxide radical, along with hydroxyl radical scavenging activity. Lipid peroxidation inhibitory potential of SAF was studied using a linoleic acid emulsion system, which shows significant antioxidant potential. SAF also demonstrated significant XO (key enzyme linked to inflammation) inhibitory activity, which revealed its therapeutic potential as an antioxidant and XO inhibitor. HPLC profiling of the ethyl acetate fraction of SAF revealed that it contains ellagic acid as a major compound and thus the beneficial effects of this fraction may be due to the presence of this compound.

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  • Authors+Show Affiliations

    ,

    Biochemistry and Cell Culture Laboratory, Agro Processing and Natural Products Division, National Institute for Interdisciplinary Science and Technology, Council of Scientific and Industrial Research, Thiruvananthapuram 695019, Kerala, India.

    , , ,

    Source

    Natural product research 25:3 2011 Feb pg 298-309

    MeSH

    Acetates
    Antioxidants
    Flowers
    Free Radical Scavengers
    Plant Extracts
    Plants, Medicinal
    Xanthine Oxidase

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21294042

    Citation

    Prathapan, A, et al. "In vitro Antiperoxidative, Free Radical Scavenging and Xanthine Oxidase Inhibitory Potentials of Ethyl Acetate Fraction of Saraca Ashoka Flowers." Natural Product Research, vol. 25, no. 3, 2011, pp. 298-309.
    Prathapan A, Lijo Cherian O, Nampoothiri SV, et al. In vitro antiperoxidative, free radical scavenging and xanthine oxidase inhibitory potentials of ethyl acetate fraction of Saraca ashoka flowers. Nat Prod Res. 2011;25(3):298-309.
    Prathapan, A., Lijo Cherian, O., Nampoothiri, S. V., Mini, S., & Raghu, K. G. (2011). In vitro antiperoxidative, free radical scavenging and xanthine oxidase inhibitory potentials of ethyl acetate fraction of Saraca ashoka flowers. Natural Product Research, 25(3), pp. 298-309. doi:10.1080/14786419.2010.510472.
    Prathapan A, et al. In vitro Antiperoxidative, Free Radical Scavenging and Xanthine Oxidase Inhibitory Potentials of Ethyl Acetate Fraction of Saraca Ashoka Flowers. Nat Prod Res. 2011;25(3):298-309. PubMed PMID: 21294042.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - In vitro antiperoxidative, free radical scavenging and xanthine oxidase inhibitory potentials of ethyl acetate fraction of Saraca ashoka flowers. AU - Prathapan,A, AU - Lijo Cherian,O, AU - Nampoothiri,Suresh V, AU - Mini,S, AU - Raghu,K G, PY - 2011/2/5/entrez PY - 2011/2/5/pubmed PY - 2011/5/12/medline SP - 298 EP - 309 JF - Natural product research JO - Nat. Prod. Res. VL - 25 IS - 3 N2 - Saraca ashoka is a widely used medicinal herb claimed to cure many diseases. This study investigated the antiperoxidative, free radical scavenging and xanthine oxidase (XO) inhibitory potential of the ethyl acetate fraction of S. ashoka flowers (SAF) and compared it with standard compounds like gallic acid, ascorbic acid, butylated hydroxyl toluene and allopurinol. The ethyl acetate fraction of SAF exhibited free radical scavenging activity against the 1,1-diphenyl-2-picrylhydrazyl radical and superoxide radical, along with hydroxyl radical scavenging activity. Lipid peroxidation inhibitory potential of SAF was studied using a linoleic acid emulsion system, which shows significant antioxidant potential. SAF also demonstrated significant XO (key enzyme linked to inflammation) inhibitory activity, which revealed its therapeutic potential as an antioxidant and XO inhibitor. HPLC profiling of the ethyl acetate fraction of SAF revealed that it contains ellagic acid as a major compound and thus the beneficial effects of this fraction may be due to the presence of this compound. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21294042/In vitro_antiperoxidative_free_radical_scavenging_and_xanthine_oxidase_inhibitory_potentials_of_ethyl_acetate_fraction_of_Saraca_ashoka_flowers_ L2 - http://www.tandfonline.com/doi/full/10.1080/14786419.2010.510472 DB - PRIME DP - Unbound Medicine ER -