Tags

Type your tag names separated by a space and hit enter

Effect of manufacturing method on the in vitro drug release and adhesive performance of drug-in-adhesive films containing binary mixtures of ibuprofen with poloxamer 188.
Pharm Dev Technol. 2012 Sep-Oct; 17(5):552-61.PD

Abstract

Drug-in-adhesive acrylic films, containing binary mixtures of ibuprofen:poloxamer 188 in 30:70, 40:60, 50:50, and 60:40 ratios, were prepared by incorporation either as physical mixture (PM), molten mixture (MM), or solid dispersion (SD). Dissolution testing showed that films prepared by MM had higher drug release compared to films prepared by PM, SD, and films containing ibuprofen alone. The MM 50:50 ratio showed the highest drug release (p < 0.05). Examination of the films by differential scanning calorimetry showed melting endotherms from the binary crystalline mixture but not from ibuprofen crystals regardless of the preparation method. Rheological measurements showed that MM films had lower elastic moduli compared to the neat adhesive, due to the plasticizing effect of the dissolved binary mixture. Fourier transfer infrared analysis confirmed the absence of ibuprofen crystal dimers in all films. It was therefore concluded that the MM method provided better mixing of the components providing crystal-free supersaturated films of high thermodynamic activity.

Authors+Show Affiliations

Sunderland Pharmacy School, Faculty of Applied Sciences, University of Sunderland, Sunderland, UK. kalliopi.dodou@sunderland.ac.ukNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21294623

Citation

Dodou, Kalliopi, and Waqaas Saddique. "Effect of Manufacturing Method On the in Vitro Drug Release and Adhesive Performance of Drug-in-adhesive Films Containing Binary Mixtures of Ibuprofen With Poloxamer 188." Pharmaceutical Development and Technology, vol. 17, no. 5, 2012, pp. 552-61.
Dodou K, Saddique W. Effect of manufacturing method on the in vitro drug release and adhesive performance of drug-in-adhesive films containing binary mixtures of ibuprofen with poloxamer 188. Pharm Dev Technol. 2012;17(5):552-61.
Dodou, K., & Saddique, W. (2012). Effect of manufacturing method on the in vitro drug release and adhesive performance of drug-in-adhesive films containing binary mixtures of ibuprofen with poloxamer 188. Pharmaceutical Development and Technology, 17(5), 552-61. https://doi.org/10.3109/10837450.2010.550687
Dodou K, Saddique W. Effect of Manufacturing Method On the in Vitro Drug Release and Adhesive Performance of Drug-in-adhesive Films Containing Binary Mixtures of Ibuprofen With Poloxamer 188. Pharm Dev Technol. 2012 Sep-Oct;17(5):552-61. PubMed PMID: 21294623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of manufacturing method on the in vitro drug release and adhesive performance of drug-in-adhesive films containing binary mixtures of ibuprofen with poloxamer 188. AU - Dodou,Kalliopi, AU - Saddique,Waqaas, Y1 - 2011/02/04/ PY - 2011/2/8/entrez PY - 2011/2/8/pubmed PY - 2013/1/8/medline SP - 552 EP - 61 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 17 IS - 5 N2 - Drug-in-adhesive acrylic films, containing binary mixtures of ibuprofen:poloxamer 188 in 30:70, 40:60, 50:50, and 60:40 ratios, were prepared by incorporation either as physical mixture (PM), molten mixture (MM), or solid dispersion (SD). Dissolution testing showed that films prepared by MM had higher drug release compared to films prepared by PM, SD, and films containing ibuprofen alone. The MM 50:50 ratio showed the highest drug release (p < 0.05). Examination of the films by differential scanning calorimetry showed melting endotherms from the binary crystalline mixture but not from ibuprofen crystals regardless of the preparation method. Rheological measurements showed that MM films had lower elastic moduli compared to the neat adhesive, due to the plasticizing effect of the dissolved binary mixture. Fourier transfer infrared analysis confirmed the absence of ibuprofen crystal dimers in all films. It was therefore concluded that the MM method provided better mixing of the components providing crystal-free supersaturated films of high thermodynamic activity. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/21294623/Effect_of_manufacturing_method_on_the_in_vitro_drug_release_and_adhesive_performance_of_drug_in_adhesive_films_containing_binary_mixtures_of_ibuprofen_with_poloxamer_188_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2010.550687 DB - PRIME DP - Unbound Medicine ER -