Tags

Type your tag names separated by a space and hit enter

Hormone replacement therapy and some risk factors for breast cancer among Slovenian postmenopausal women.
Climacteric 2011; 14(4):458-63C

Abstract

OBJECTIVE

The aim of the study was to examine the influence of the use of hormone replacement therapy (HRT) and of some generally recognized risk factors on breast cancer risk among Slovenian postmenopausal women.

METHODS

Eligible women diagnosed with breast cancer and a control group of women of the same age and ethnicity were invited to participate in the case-control study via a personal letter and asked to complete a written questionnaire. Adjusted odds ratios and 95% confidence intervals were estimated using multivariate logistic regression analysis.

RESULTS

A total of 784 cases and 709 controls aged 50-69 years were enrolled. HRT use was inversely associated with breast cancer risk. The effect was most pronounced with the use of estrogen-only replacement therapy (odds ratio (OR) 0.51, 95% confidence interval (CI) 0.30-0.87). Longer duration of HRT use did not result in a significant change in risk (1 to <5 years of HRT use: OR 0.44, 95% CI 0.26-0.73; ≥ 5 years of HRT use: OR 0.51, 95% CI 0.30-0.87). Obesity (25 ≤ body mass index <30 kg/m(2): OR 1.34, 95% CI 1.04-1.73; body mass index ≥ 30 kg/m(2): OR 1.89, 95% CI 1.36-2.63), smoking ≥ 10 cigarettes per day (OR 1.70, 95% CI 1.20-2.43), and any first-degree relative with breast or ovarian cancer (OR 1.52, 95% CI 1.11-2.08) were positively associated with breast cancer risk.

CONCLUSIONS

Our analysis revealed some differences from the previously published literature, which might reflect underlying demographic changes. Comprehensive medical care in HRT users without pre-existing breast abnormalities probably reduces the incidence of new breast cancer cases in Slovenia.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21294673

Citation

Cerne, J Z., et al. "Hormone Replacement Therapy and some Risk Factors for Breast Cancer Among Slovenian Postmenopausal Women." Climacteric : the Journal of the International Menopause Society, vol. 14, no. 4, 2011, pp. 458-63.
Cerne JZ, Ferk P, Leskosek B, et al. Hormone replacement therapy and some risk factors for breast cancer among Slovenian postmenopausal women. Climacteric. 2011;14(4):458-63.
Cerne, J. Z., Ferk, P., Leskosek, B., & Gersak, K. (2011). Hormone replacement therapy and some risk factors for breast cancer among Slovenian postmenopausal women. Climacteric : the Journal of the International Menopause Society, 14(4), pp. 458-63. doi:10.3109/13697137.2010.541307.
Cerne JZ, et al. Hormone Replacement Therapy and some Risk Factors for Breast Cancer Among Slovenian Postmenopausal Women. Climacteric. 2011;14(4):458-63. PubMed PMID: 21294673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormone replacement therapy and some risk factors for breast cancer among Slovenian postmenopausal women. AU - Cerne,J Z, AU - Ferk,P, AU - Leskosek,B, AU - Gersak,K, Y1 - 2011/02/07/ PY - 2011/2/8/entrez PY - 2011/2/8/pubmed PY - 2011/11/16/medline SP - 458 EP - 63 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 14 IS - 4 N2 - OBJECTIVE: The aim of the study was to examine the influence of the use of hormone replacement therapy (HRT) and of some generally recognized risk factors on breast cancer risk among Slovenian postmenopausal women. METHODS: Eligible women diagnosed with breast cancer and a control group of women of the same age and ethnicity were invited to participate in the case-control study via a personal letter and asked to complete a written questionnaire. Adjusted odds ratios and 95% confidence intervals were estimated using multivariate logistic regression analysis. RESULTS: A total of 784 cases and 709 controls aged 50-69 years were enrolled. HRT use was inversely associated with breast cancer risk. The effect was most pronounced with the use of estrogen-only replacement therapy (odds ratio (OR) 0.51, 95% confidence interval (CI) 0.30-0.87). Longer duration of HRT use did not result in a significant change in risk (1 to <5 years of HRT use: OR 0.44, 95% CI 0.26-0.73; ≥ 5 years of HRT use: OR 0.51, 95% CI 0.30-0.87). Obesity (25 ≤ body mass index <30 kg/m(2): OR 1.34, 95% CI 1.04-1.73; body mass index ≥ 30 kg/m(2): OR 1.89, 95% CI 1.36-2.63), smoking ≥ 10 cigarettes per day (OR 1.70, 95% CI 1.20-2.43), and any first-degree relative with breast or ovarian cancer (OR 1.52, 95% CI 1.11-2.08) were positively associated with breast cancer risk. CONCLUSIONS: Our analysis revealed some differences from the previously published literature, which might reflect underlying demographic changes. Comprehensive medical care in HRT users without pre-existing breast abnormalities probably reduces the incidence of new breast cancer cases in Slovenia. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/21294673/Hormone_replacement_therapy_and_some_risk_factors_for_breast_cancer_among_Slovenian_postmenopausal_women_ L2 - http://www.tandfonline.com/doi/full/10.3109/13697137.2010.541307 DB - PRIME DP - Unbound Medicine ER -