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Abnormal fatty acid profile in chronic hemodialysis patients: possible deficiency of essential fatty acids.
Clin Physiol Biochem. 1990; 8(5):238-43.CP

Abstract

Plasma fatty acid profiles from maintenance hemodialysis patients (n = 9) were compared with those from healthy volunteers (n = 9). Hemodialysis patients had significantly higher levels of oleic acid, 15.3 +/- 1.1 vs. 8.9 +/- 0.6% (p less than 0.0001), and lower levels of arachidonic acid (6.0 +/- 0.5 vs. 8.4 +/- 0.3%, p less than 0.0009). Linolenic and linoleic acids, the essential fatty acid and precursors of arachidonic acid, were also significantly lower than normal in the dialysis group. These data show that dialysis patients have fatty acid abnormalities suggesting relative depletion of essential fatty acids. These observations are important because these abnormalities may play an important role in the pathogenesis of some common clinical conditions associated with uremia, such as a constellation of skin problems, fragility of erythrocytes, lipid anomalies and hormonal aberrations.

Authors+Show Affiliations

Department of Pathology, University of Chicago Prizker School of Medicine, Ill.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2129482

Citation

Dasgupta, A, et al. "Abnormal Fatty Acid Profile in Chronic Hemodialysis Patients: Possible Deficiency of Essential Fatty Acids." Clinical Physiology and Biochemistry, vol. 8, no. 5, 1990, pp. 238-43.
Dasgupta A, Kenny MA, Ahmad S. Abnormal fatty acid profile in chronic hemodialysis patients: possible deficiency of essential fatty acids. Clin Physiol Biochem. 1990;8(5):238-43.
Dasgupta, A., Kenny, M. A., & Ahmad, S. (1990). Abnormal fatty acid profile in chronic hemodialysis patients: possible deficiency of essential fatty acids. Clinical Physiology and Biochemistry, 8(5), 238-43.
Dasgupta A, Kenny MA, Ahmad S. Abnormal Fatty Acid Profile in Chronic Hemodialysis Patients: Possible Deficiency of Essential Fatty Acids. Clin Physiol Biochem. 1990;8(5):238-43. PubMed PMID: 2129482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal fatty acid profile in chronic hemodialysis patients: possible deficiency of essential fatty acids. AU - Dasgupta,A, AU - Kenny,M A, AU - Ahmad,S, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 238 EP - 43 JF - Clinical physiology and biochemistry JO - Clin Physiol Biochem VL - 8 IS - 5 N2 - Plasma fatty acid profiles from maintenance hemodialysis patients (n = 9) were compared with those from healthy volunteers (n = 9). Hemodialysis patients had significantly higher levels of oleic acid, 15.3 +/- 1.1 vs. 8.9 +/- 0.6% (p less than 0.0001), and lower levels of arachidonic acid (6.0 +/- 0.5 vs. 8.4 +/- 0.3%, p less than 0.0009). Linolenic and linoleic acids, the essential fatty acid and precursors of arachidonic acid, were also significantly lower than normal in the dialysis group. These data show that dialysis patients have fatty acid abnormalities suggesting relative depletion of essential fatty acids. These observations are important because these abnormalities may play an important role in the pathogenesis of some common clinical conditions associated with uremia, such as a constellation of skin problems, fragility of erythrocytes, lipid anomalies and hormonal aberrations. SN - 0252-1164 UR - https://www.unboundmedicine.com/medline/citation/2129482/Abnormal_fatty_acid_profile_in_chronic_hemodialysis_patients:_possible_deficiency_of_essential_fatty_acids_ L2 - https://medlineplus.gov/dialysis.html DB - PRIME DP - Unbound Medicine ER -