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Dietary fat intake and the risk of depression: the SUN Project.
PLoS One. 2011 Jan 26; 6(1):e16268.Plos

Abstract

Emerging evidence relates some nutritional factors to depression risk. However, there is a scarcity of longitudinal assessments on this relationship.

OBJECTIVE

To evaluate the association between fatty acid intake or the use of culinary fats and depression incidence in a Mediterranean population.

MATERIAL AND METHODS

Prospective cohort study (1999-2010) of 12,059 Spanish university graduates (mean age: 37.5 years) initially free of depression with permanently open enrolment. At baseline, a 136-item validated food frequency questionnaire was used to estimate the intake of fatty acids (saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA), trans unsaturated fatty acids (TFA) and monounsaturated fatty acids (MUFA) and culinary fats (olive oil, seed oils, butter and margarine) During follow-up participants were classified as incident cases of depression if they reported a new clinical diagnosis of depression by a physician and/or initiated the use of antidepressant drugs. Cox regression models were used to calculate Hazard Ratios (HR) of incident depression and their 95% confidence intervals (CI) for successive quintiles of fats.

RESULTS

During follow-up (median: 6.1 years), 657 new cases of depression were identified. Multivariable-adjusted HR (95% CI) for depression incidence across successive quintiles of TFA intake were: 1 (ref), 1.08 (0.82-1.43), 1.17 (0.88-1.53), 1.28 (0.97-1.68), 1.42 (1.09-1.84) with a significant dose-response relationship (p for trend = 0.003). Results did not substantially change after adjusting for potential lifestyle or dietary confounders, including adherence to a Mediterranean Dietary Pattern. On the other hand, an inverse and significant dose-response relationship was obtained for MUFA (p for trend = 0.05) and PUFA (p for trend = 0.03) intake.

CONCLUSIONS

A detrimental relationship was found between TFA intake and depression risk, whereas weak inverse associations were found for MUFA, PUFA and olive oil. These findings suggest that cardiovascular disease and depression may share some common nutritional determinants related to subtypes of fat intake.

Authors+Show Affiliations

Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. asanchez@dcc.ulpgc.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21298116

Citation

Sánchez-Villegas, Almudena, et al. "Dietary Fat Intake and the Risk of Depression: the SUN Project." PloS One, vol. 6, no. 1, 2011, pp. e16268.
Sánchez-Villegas A, Verberne L, De Irala J, et al. Dietary fat intake and the risk of depression: the SUN Project. PLoS ONE. 2011;6(1):e16268.
Sánchez-Villegas, A., Verberne, L., De Irala, J., Ruíz-Canela, M., Toledo, E., Serra-Majem, L., & Martínez-González, M. A. (2011). Dietary fat intake and the risk of depression: the SUN Project. PloS One, 6(1), e16268. https://doi.org/10.1371/journal.pone.0016268
Sánchez-Villegas A, et al. Dietary Fat Intake and the Risk of Depression: the SUN Project. PLoS ONE. 2011 Jan 26;6(1):e16268. PubMed PMID: 21298116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat intake and the risk of depression: the SUN Project. AU - Sánchez-Villegas,Almudena, AU - Verberne,Lisa, AU - De Irala,Jokin, AU - Ruíz-Canela,Miguel, AU - Toledo,Estefanía, AU - Serra-Majem,Lluis, AU - Martínez-González,Miguel Angel, Y1 - 2011/01/26/ PY - 2010/09/03/received PY - 2010/12/09/accepted PY - 2011/2/8/entrez PY - 2011/2/8/pubmed PY - 2011/8/4/medline SP - e16268 EP - e16268 JF - PloS one JO - PLoS ONE VL - 6 IS - 1 N2 - UNLABELLED: Emerging evidence relates some nutritional factors to depression risk. However, there is a scarcity of longitudinal assessments on this relationship. OBJECTIVE: To evaluate the association between fatty acid intake or the use of culinary fats and depression incidence in a Mediterranean population. MATERIAL AND METHODS: Prospective cohort study (1999-2010) of 12,059 Spanish university graduates (mean age: 37.5 years) initially free of depression with permanently open enrolment. At baseline, a 136-item validated food frequency questionnaire was used to estimate the intake of fatty acids (saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA), trans unsaturated fatty acids (TFA) and monounsaturated fatty acids (MUFA) and culinary fats (olive oil, seed oils, butter and margarine) During follow-up participants were classified as incident cases of depression if they reported a new clinical diagnosis of depression by a physician and/or initiated the use of antidepressant drugs. Cox regression models were used to calculate Hazard Ratios (HR) of incident depression and their 95% confidence intervals (CI) for successive quintiles of fats. RESULTS: During follow-up (median: 6.1 years), 657 new cases of depression were identified. Multivariable-adjusted HR (95% CI) for depression incidence across successive quintiles of TFA intake were: 1 (ref), 1.08 (0.82-1.43), 1.17 (0.88-1.53), 1.28 (0.97-1.68), 1.42 (1.09-1.84) with a significant dose-response relationship (p for trend = 0.003). Results did not substantially change after adjusting for potential lifestyle or dietary confounders, including adherence to a Mediterranean Dietary Pattern. On the other hand, an inverse and significant dose-response relationship was obtained for MUFA (p for trend = 0.05) and PUFA (p for trend = 0.03) intake. CONCLUSIONS: A detrimental relationship was found between TFA intake and depression risk, whereas weak inverse associations were found for MUFA, PUFA and olive oil. These findings suggest that cardiovascular disease and depression may share some common nutritional determinants related to subtypes of fat intake. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/21298116/Dietary_fat_intake_and_the_risk_of_depression:_the_SUN_Project_ L2 - http://dx.plos.org/10.1371/journal.pone.0016268 DB - PRIME DP - Unbound Medicine ER -