Tags

Type your tag names separated by a space and hit enter

Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas.
J Gastroenterol Hepatol. 1990 Sep-Oct; 5(5):525-9.JG

Abstract

Recently, carboxyl terminal glycine extended progastrin (gastrin-G), the immediate biosynthetic precursor of amidated gastrin, was found in human gastric antral mucosa. To investigate in pathophysiological conditions, we examined gastrin and gastrin-G levels and their molecular forms in gastric antral mucosa of healthy controls and patients with gastric or duodenal ulcer and in gastrinomas. There were no significant differences between controls and gastric or duodenal ulcer patients in antral gastrin and gastrin-G levels, the ratio of gastrin-G to gastrin and the pattern of their molecular forms. In contrast, gastrin and gastrin-G levels and the ratio of gastrin-G to gastrin in gastrinomas were much higher than those in antral mucosa of controls or ulcer patients. The predominant molecular form of gastrin-G was different between two Zollinger-Ellison syndrome (ZES) cases. These results suggest that there are no significant differences between healthy controls and patients with gastric or duodenal ulcer in the nature of gastrin amidation, and that the nature of gastrin amination in gastrinomas is different from that in normal gastrointestinal tissues.

Authors+Show Affiliations

Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2129824

Citation

Azuma, T, et al. "Carboxyl Terminal Glycine Extended Progastrin (gastrin-G) in Gastric Antral Mucosa of Patients With Gastric or Duodenal Ulcer and in Gastrinomas." Journal of Gastroenterology and Hepatology, vol. 5, no. 5, 1990, pp. 525-9.
Azuma T, Magami Y, Habu Y, et al. Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas. J Gastroenterol Hepatol. 1990;5(5):525-9.
Azuma, T., Magami, Y., Habu, Y., Kawai, K., Taggart, R. T., & Walsh, J. H. (1990). Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas. Journal of Gastroenterology and Hepatology, 5(5), 525-9.
Azuma T, et al. Carboxyl Terminal Glycine Extended Progastrin (gastrin-G) in Gastric Antral Mucosa of Patients With Gastric or Duodenal Ulcer and in Gastrinomas. J Gastroenterol Hepatol. 1990 Sep-Oct;5(5):525-9. PubMed PMID: 2129824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas. AU - Azuma,T, AU - Magami,Y, AU - Habu,Y, AU - Kawai,K, AU - Taggart,R T, AU - Walsh,J H, PY - 1990/9/1/pubmed PY - 1990/9/1/medline PY - 1990/9/1/entrez SP - 525 EP - 9 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 5 IS - 5 N2 - Recently, carboxyl terminal glycine extended progastrin (gastrin-G), the immediate biosynthetic precursor of amidated gastrin, was found in human gastric antral mucosa. To investigate in pathophysiological conditions, we examined gastrin and gastrin-G levels and their molecular forms in gastric antral mucosa of healthy controls and patients with gastric or duodenal ulcer and in gastrinomas. There were no significant differences between controls and gastric or duodenal ulcer patients in antral gastrin and gastrin-G levels, the ratio of gastrin-G to gastrin and the pattern of their molecular forms. In contrast, gastrin and gastrin-G levels and the ratio of gastrin-G to gastrin in gastrinomas were much higher than those in antral mucosa of controls or ulcer patients. The predominant molecular form of gastrin-G was different between two Zollinger-Ellison syndrome (ZES) cases. These results suggest that there are no significant differences between healthy controls and patients with gastric or duodenal ulcer in the nature of gastrin amidation, and that the nature of gastrin amination in gastrinomas is different from that in normal gastrointestinal tissues. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/2129824/Carboxyl_terminal_glycine_extended_progastrin__gastrin_G__in_gastric_antral_mucosa_of_patients_with_gastric_or_duodenal_ulcer_and_in_gastrinomas_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=1990&volume=5&issue=5&spage=525 DB - PRIME DP - Unbound Medicine ER -