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The heptavalent pneumococcal conjugate vaccine immunization project by Bangkok Metropolitan in Thai infants.
J Med Assoc Thai. 2010 Nov; 93 Suppl 5:S13-5.JM

Abstract

BACKGROUND

Streptococcus pneumoniae is the most common cause of bacteremia, sepsis, meningitis, pneumonia, sinusitis and otitis media in children worldwide. Several studies have shown that the heptavalent pneumococcal conjugate vaccine (PCV7) is highly immunogenic, safe and effective against disease caused by serotypes contained in the vaccine.

OBJECTIVE

To determine the safety and efficacy of PCV7 administered to Thai infants.

MATERIAL AND METHOD

Ninety-seven infants received four doses of PCV7. Three primary doses were given 2 months apart starting at the age of 2-6 months and the booster dose at the age of 12-15 months. Reactogenicity and safety were evaluated from parent reports. The impact of PCV7 on the occurrence of invasive pneumococcal disease (IPD) among vaccinees was examined.

RESULTS

PCV7 was well tolerated. Two infants reported low-grade fever. None of the vaccinees developed IPD during the 1-year period following the first PCV7 dose.

CONCLUSION

Primary immunization followed by a booster dose of PCV7 appeared safe and efficactive in preventing IPD in Thai children.

Authors+Show Affiliations

Communicable Disease Control Division, Health Department, Bangkok Metropolitan, Bangkok, Thailand.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21298831

Citation

Liulak, Wongwat, and Usa Thisyakorn. "The Heptavalent Pneumococcal Conjugate Vaccine Immunization Project By Bangkok Metropolitan in Thai Infants." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 93 Suppl 5, 2010, pp. S13-5.
Liulak W, Thisyakorn U. The heptavalent pneumococcal conjugate vaccine immunization project by Bangkok Metropolitan in Thai infants. J Med Assoc Thai. 2010;93 Suppl 5:S13-5.
Liulak, W., & Thisyakorn, U. (2010). The heptavalent pneumococcal conjugate vaccine immunization project by Bangkok Metropolitan in Thai infants. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 93 Suppl 5, S13-5.
Liulak W, Thisyakorn U. The Heptavalent Pneumococcal Conjugate Vaccine Immunization Project By Bangkok Metropolitan in Thai Infants. J Med Assoc Thai. 2010;93 Suppl 5:S13-5. PubMed PMID: 21298831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The heptavalent pneumococcal conjugate vaccine immunization project by Bangkok Metropolitan in Thai infants. AU - Liulak,Wongwat, AU - Thisyakorn,Usa, PY - 2011/2/8/entrez PY - 2011/2/8/pubmed PY - 2011/3/2/medline SP - S13 EP - 5 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 93 Suppl 5 N2 - BACKGROUND: Streptococcus pneumoniae is the most common cause of bacteremia, sepsis, meningitis, pneumonia, sinusitis and otitis media in children worldwide. Several studies have shown that the heptavalent pneumococcal conjugate vaccine (PCV7) is highly immunogenic, safe and effective against disease caused by serotypes contained in the vaccine. OBJECTIVE: To determine the safety and efficacy of PCV7 administered to Thai infants. MATERIAL AND METHOD: Ninety-seven infants received four doses of PCV7. Three primary doses were given 2 months apart starting at the age of 2-6 months and the booster dose at the age of 12-15 months. Reactogenicity and safety were evaluated from parent reports. The impact of PCV7 on the occurrence of invasive pneumococcal disease (IPD) among vaccinees was examined. RESULTS: PCV7 was well tolerated. Two infants reported low-grade fever. None of the vaccinees developed IPD during the 1-year period following the first PCV7 dose. CONCLUSION: Primary immunization followed by a booster dose of PCV7 appeared safe and efficactive in preventing IPD in Thai children. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/21298831/The_heptavalent_pneumococcal_conjugate_vaccine_immunization_project_by_Bangkok_Metropolitan_in_Thai_infants_ L2 - https://medlineplus.gov/pneumococcalinfections.html DB - PRIME DP - Unbound Medicine ER -