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Changing epidemiology of invasive pneumococcal disease in Australian children after introduction of a 7-valent pneumococcal conjugate vaccine.
Med J Aust. 2011 Feb 07; 194(3):116-20.MJ

Abstract

OBJECTIVE

To evaluate trends in the incidence and serotype profile of invasive pneumococcal disease (IPD) in Australian children under 2 years of age after the introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV).

DESIGN AND SETTING

Analysis of incidence rates calculated using IPD surveillance data (including age, Indigenous status and serotype of the pneumococcal isolate) from 2002 to 2007 obtained from the National Notifiable Diseases Surveillance System and population estimates obtained from the Australian Bureau of Statistics.

MAIN OUTCOME MEASURES

Trends in IPD incidence among Indigenous and non-Indigenous children between 2002 and 2007; change in the serotype profile of IPD in non-Indigenous children after the introduction of universal 7vPCV vaccination in 2005.

RESULTS

Overall incidence of IPD decreased by 74% in all children < 2 years of age between 2002 and 2007 (P < 0.001). While the incidence of IPD caused by 7vPCV serotypes decreased significantly among both Indigenous and non-Indigenous children, the incidence of non-7vPCV serotype IPD increased significantly in non-Indigenous children (from 9.7 to 15.7 per 100 000, P < 0.001). Compared with a pre-vaccination period (2002-2004), the 2007 incidence of serotype 19A IPD in non-Indigenous children increased significantly (from 2.7 to 8.6 per 100 000, P < 0.001). In 2007, 19A was the predominant serotype causing IPD (37.7%) in all children aged < 2 years.

CONCLUSIONS

The overall incidence of IPD decreased from 2002 to 2007, primarily driven by a reduction in IPD caused by 7vPCV serotypes. However, this was partially offset by a significant increase in the incidence of IPD caused by non-7vPCV serotypes, particularly 19A, in non-Indigenous children.

Authors+Show Affiliations

Specialty Care Business Unit, Pfizer Australia, Sydney, NSW, Australia. scott.williams@pfizer.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21299484

Citation

Williams, Scott R., et al. "Changing Epidemiology of Invasive Pneumococcal Disease in Australian Children After Introduction of a 7-valent Pneumococcal Conjugate Vaccine." The Medical Journal of Australia, vol. 194, no. 3, 2011, pp. 116-20.
Williams SR, Mernagh PJ, Lee MH, et al. Changing epidemiology of invasive pneumococcal disease in Australian children after introduction of a 7-valent pneumococcal conjugate vaccine. Med J Aust. 2011;194(3):116-20.
Williams, S. R., Mernagh, P. J., Lee, M. H., & Tan, J. T. (2011). Changing epidemiology of invasive pneumococcal disease in Australian children after introduction of a 7-valent pneumococcal conjugate vaccine. The Medical Journal of Australia, 194(3), 116-20.
Williams SR, et al. Changing Epidemiology of Invasive Pneumococcal Disease in Australian Children After Introduction of a 7-valent Pneumococcal Conjugate Vaccine. Med J Aust. 2011 Feb 7;194(3):116-20. PubMed PMID: 21299484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changing epidemiology of invasive pneumococcal disease in Australian children after introduction of a 7-valent pneumococcal conjugate vaccine. AU - Williams,Scott R, AU - Mernagh,Paul J, AU - Lee,Michael H T, AU - Tan,Jonathan T, PY - 2010/06/23/received PY - 2010/10/24/accepted PY - 2011/2/9/entrez PY - 2011/2/9/pubmed PY - 2011/3/30/medline SP - 116 EP - 20 JF - The Medical journal of Australia JO - Med J Aust VL - 194 IS - 3 N2 - OBJECTIVE: To evaluate trends in the incidence and serotype profile of invasive pneumococcal disease (IPD) in Australian children under 2 years of age after the introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV). DESIGN AND SETTING: Analysis of incidence rates calculated using IPD surveillance data (including age, Indigenous status and serotype of the pneumococcal isolate) from 2002 to 2007 obtained from the National Notifiable Diseases Surveillance System and population estimates obtained from the Australian Bureau of Statistics. MAIN OUTCOME MEASURES: Trends in IPD incidence among Indigenous and non-Indigenous children between 2002 and 2007; change in the serotype profile of IPD in non-Indigenous children after the introduction of universal 7vPCV vaccination in 2005. RESULTS: Overall incidence of IPD decreased by 74% in all children < 2 years of age between 2002 and 2007 (P < 0.001). While the incidence of IPD caused by 7vPCV serotypes decreased significantly among both Indigenous and non-Indigenous children, the incidence of non-7vPCV serotype IPD increased significantly in non-Indigenous children (from 9.7 to 15.7 per 100 000, P < 0.001). Compared with a pre-vaccination period (2002-2004), the 2007 incidence of serotype 19A IPD in non-Indigenous children increased significantly (from 2.7 to 8.6 per 100 000, P < 0.001). In 2007, 19A was the predominant serotype causing IPD (37.7%) in all children aged < 2 years. CONCLUSIONS: The overall incidence of IPD decreased from 2002 to 2007, primarily driven by a reduction in IPD caused by 7vPCV serotypes. However, this was partially offset by a significant increase in the incidence of IPD caused by non-7vPCV serotypes, particularly 19A, in non-Indigenous children. SN - 1326-5377 UR - https://www.unboundmedicine.com/medline/citation/21299484/Changing_epidemiology_of_invasive_pneumococcal_disease_in_Australian_children_after_introduction_of_a_7_valent_pneumococcal_conjugate_vaccine_ L2 - https://www.mja.com.au/public/issues/194_03_070211/wil10655_fm.html DB - PRIME DP - Unbound Medicine ER -