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Reducing nocturia in the elderly: a randomized placebo-controlled trial of staggered furosemide and desmopressin.
Neurourol Urodyn. 2011 Mar; 30(3):312-6.NU

Abstract

AIMS

The purpose of this study was to investigate efficacy, safety, and impact on quality of sleep of staggered furosemide and desmopressin in the treatment of nocturia in the elderly.

METHODS

Patients aged >60 years with nocturia at least two voids per night were screened for enrollment into the study. A 3-week dose-titration phase established the optimum desmopressin dose (0.1, 0.2, or 0.4 mg). After a 1-week "washout" period, patients who showed sufficient response during the dose-titration period were randomized to receive staggered furosemide and the optimal dose of desmopressin or placebo in a double-blind design for 3 weeks. Voiding diaries were assessed before and after the treatment.

RESULTS

In all, 82 patients were randomized to either staggered furosemide and desmopressin (n=41) or placebo (n=41). In the study group, most patients reported a good response with both reduced nocturnal voids (3.5 vs. 2.0, P<0.01) and urine volume (919.6 ml vs. 584.2 ml, P<0.01). The mean duration of the first sleep period was improved by 70 min (133.6 vs. 203.2, P<0.01). Compared to placebo, staggered furosemide and desmopressin resulted in a significant reduction in the mean number of nocturnal voids (43% vs. 9%; P<0.01), nocturnal urine volume (37% vs. 5%; P<0.01), and increase in the mean duration of the first sleep period (52% vs. 19%, P<0.01). Adverse events were mild.

CONCLUSIONS

Staggered furosemide and desmopressin provide an effective and well-tolerated treatment for nocturia in the elderly.

Authors+Show Affiliations

Department of Urology, TongJi Hospital, TongJi University School of Medicine, Shanghai, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21305590

Citation

Fu, Fei-Guo, et al. "Reducing Nocturia in the Elderly: a Randomized Placebo-controlled Trial of Staggered Furosemide and Desmopressin." Neurourology and Urodynamics, vol. 30, no. 3, 2011, pp. 312-6.
Fu FG, Lavery HJ, Wu DL. Reducing nocturia in the elderly: a randomized placebo-controlled trial of staggered furosemide and desmopressin. Neurourol Urodyn. 2011;30(3):312-6.
Fu, F. G., Lavery, H. J., & Wu, D. L. (2011). Reducing nocturia in the elderly: a randomized placebo-controlled trial of staggered furosemide and desmopressin. Neurourology and Urodynamics, 30(3), 312-6. https://doi.org/10.1002/nau.20986
Fu FG, Lavery HJ, Wu DL. Reducing Nocturia in the Elderly: a Randomized Placebo-controlled Trial of Staggered Furosemide and Desmopressin. Neurourol Urodyn. 2011;30(3):312-6. PubMed PMID: 21305590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reducing nocturia in the elderly: a randomized placebo-controlled trial of staggered furosemide and desmopressin. AU - Fu,Fei-Guo, AU - Lavery,Hugh J, AU - Wu,Deng-Long, Y1 - 2011/02/08/ PY - 2010/03/07/received PY - 2010/07/01/accepted PY - 2011/2/10/entrez PY - 2011/2/10/pubmed PY - 2011/7/1/medline SP - 312 EP - 6 JF - Neurourology and urodynamics JO - Neurourol Urodyn VL - 30 IS - 3 N2 - AIMS: The purpose of this study was to investigate efficacy, safety, and impact on quality of sleep of staggered furosemide and desmopressin in the treatment of nocturia in the elderly. METHODS: Patients aged >60 years with nocturia at least two voids per night were screened for enrollment into the study. A 3-week dose-titration phase established the optimum desmopressin dose (0.1, 0.2, or 0.4 mg). After a 1-week "washout" period, patients who showed sufficient response during the dose-titration period were randomized to receive staggered furosemide and the optimal dose of desmopressin or placebo in a double-blind design for 3 weeks. Voiding diaries were assessed before and after the treatment. RESULTS: In all, 82 patients were randomized to either staggered furosemide and desmopressin (n=41) or placebo (n=41). In the study group, most patients reported a good response with both reduced nocturnal voids (3.5 vs. 2.0, P<0.01) and urine volume (919.6 ml vs. 584.2 ml, P<0.01). The mean duration of the first sleep period was improved by 70 min (133.6 vs. 203.2, P<0.01). Compared to placebo, staggered furosemide and desmopressin resulted in a significant reduction in the mean number of nocturnal voids (43% vs. 9%; P<0.01), nocturnal urine volume (37% vs. 5%; P<0.01), and increase in the mean duration of the first sleep period (52% vs. 19%, P<0.01). Adverse events were mild. CONCLUSIONS: Staggered furosemide and desmopressin provide an effective and well-tolerated treatment for nocturia in the elderly. SN - 1520-6777 UR - https://www.unboundmedicine.com/medline/citation/21305590/Reducing_nocturia_in_the_elderly:_a_randomized_placebo_controlled_trial_of_staggered_furosemide_and_desmopressin_ L2 - https://doi.org/10.1002/nau.20986 DB - PRIME DP - Unbound Medicine ER -