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Follicular phase endocrine characteristics during ovarian stimulation and GnRH antagonist cotreatment for IVF: RCT comparing recFSH initiated on cycle day 2 or 5.
J Clin Endocrinol Metab. 2011 Apr; 96(4):1122-8.JC

Abstract

CONTEXT

Strategies involving mild ovarian stimulation protocols for in vitro fertilization (IVF) might lessen discomfort to the patient and substantially lower complication rates.

OBJECTIVE

The objective of the study was to compare the follicular-phase endocrine characteristics and follicular development in patients who started recombinant FSH (recFSH) on cycle day (CD) 2 or CD5 in IVF treatment, using GnRH antagonist as comedication.

DESIGN

This was a prospective randomized controlled trial in two university centers in Belgium and The Netherlands.

PATIENTS

Seventy-six IVF/intracytoplasmic sperm injection patients were included in the study.

INTERVENTIONS

The control group (CD2) received a standard treatment with 150 IU recFSH from CD2, whereas in the study group (CD5), stimulation was started on d 5 of the cycle. The GnRH antagonist was administered daily from CD6 onward in both treatment arms.

MAIN OUTCOME MEASURE

Endocrine follicular phase profile during ovarian stimulation was measured.

RESULTS

Follicular-phase patterns of gonadotropin and steroid concentrations were found to be comparable in both treatment groups, except for serum estradiol being significantly higher in the CD2 group on d 6 of the cycle (295.6 ± 202.5 ng/liter in the CD2 vs. 102.5 ± 47.9 ng/liter in the CD5 group; P < 0.01) and LH being significantly higher in the CD5 group on d 6 of the cycle (1.7 ± 0.7 IU/liter in the CD2 vs. 5.0 ± 2.1 IU/liter in the CD5 group; P < 0.01). With regard to follicular development, there was no difference in the numbers of small follicles (<10 mm), intermediate follicles (10-12 and > 12-14 mm) and large follicles (>14 mm) in both groups.

CONCLUSIONS

This study shows that the administration of recFSH starting on d 2 or d 5 of the cycle in a GnRH antagonist protocol for IVF/intracytoplasmic sperm injection patients yields a comparable endocrine profile and follicular development. Future studies should focus on the design of more patient-tailored ovarian stimulation protocols.

Authors+Show Affiliations

Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium. christophe.blockeel@uzbrussel.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21307142

Citation

Blockeel, Christophe, et al. "Follicular Phase Endocrine Characteristics During Ovarian Stimulation and GnRH Antagonist Cotreatment for IVF: RCT Comparing recFSH Initiated On Cycle Day 2 or 5." The Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 4, 2011, pp. 1122-8.
Blockeel C, Sterrenburg MD, Broekmans FJ, et al. Follicular phase endocrine characteristics during ovarian stimulation and GnRH antagonist cotreatment for IVF: RCT comparing recFSH initiated on cycle day 2 or 5. J Clin Endocrinol Metab. 2011;96(4):1122-8.
Blockeel, C., Sterrenburg, M. D., Broekmans, F. J., Eijkemans, M. J., Smitz, J., Devroey, P., & Fauser, B. C. (2011). Follicular phase endocrine characteristics during ovarian stimulation and GnRH antagonist cotreatment for IVF: RCT comparing recFSH initiated on cycle day 2 or 5. The Journal of Clinical Endocrinology and Metabolism, 96(4), 1122-8. https://doi.org/10.1210/jc.2010-2239
Blockeel C, et al. Follicular Phase Endocrine Characteristics During Ovarian Stimulation and GnRH Antagonist Cotreatment for IVF: RCT Comparing recFSH Initiated On Cycle Day 2 or 5. J Clin Endocrinol Metab. 2011;96(4):1122-8. PubMed PMID: 21307142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follicular phase endocrine characteristics during ovarian stimulation and GnRH antagonist cotreatment for IVF: RCT comparing recFSH initiated on cycle day 2 or 5. AU - Blockeel,Christophe, AU - Sterrenburg,Monique D, AU - Broekmans,Frank J, AU - Eijkemans,Marinus J C, AU - Smitz,Johan, AU - Devroey,Paul, AU - Fauser,Bart C J M, Y1 - 2011/02/09/ PY - 2011/2/11/entrez PY - 2011/2/11/pubmed PY - 2011/6/15/medline SP - 1122 EP - 8 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 96 IS - 4 N2 - CONTEXT: Strategies involving mild ovarian stimulation protocols for in vitro fertilization (IVF) might lessen discomfort to the patient and substantially lower complication rates. OBJECTIVE: The objective of the study was to compare the follicular-phase endocrine characteristics and follicular development in patients who started recombinant FSH (recFSH) on cycle day (CD) 2 or CD5 in IVF treatment, using GnRH antagonist as comedication. DESIGN: This was a prospective randomized controlled trial in two university centers in Belgium and The Netherlands. PATIENTS: Seventy-six IVF/intracytoplasmic sperm injection patients were included in the study. INTERVENTIONS: The control group (CD2) received a standard treatment with 150 IU recFSH from CD2, whereas in the study group (CD5), stimulation was started on d 5 of the cycle. The GnRH antagonist was administered daily from CD6 onward in both treatment arms. MAIN OUTCOME MEASURE: Endocrine follicular phase profile during ovarian stimulation was measured. RESULTS: Follicular-phase patterns of gonadotropin and steroid concentrations were found to be comparable in both treatment groups, except for serum estradiol being significantly higher in the CD2 group on d 6 of the cycle (295.6 ± 202.5 ng/liter in the CD2 vs. 102.5 ± 47.9 ng/liter in the CD5 group; P < 0.01) and LH being significantly higher in the CD5 group on d 6 of the cycle (1.7 ± 0.7 IU/liter in the CD2 vs. 5.0 ± 2.1 IU/liter in the CD5 group; P < 0.01). With regard to follicular development, there was no difference in the numbers of small follicles (<10 mm), intermediate follicles (10-12 and > 12-14 mm) and large follicles (>14 mm) in both groups. CONCLUSIONS: This study shows that the administration of recFSH starting on d 2 or d 5 of the cycle in a GnRH antagonist protocol for IVF/intracytoplasmic sperm injection patients yields a comparable endocrine profile and follicular development. Future studies should focus on the design of more patient-tailored ovarian stimulation protocols. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/21307142/Follicular_phase_endocrine_characteristics_during_ovarian_stimulation_and_GnRH_antagonist_cotreatment_for_IVF:_RCT_comparing_recFSH_initiated_on_cycle_day_2_or_5_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2010-2239 DB - PRIME DP - Unbound Medicine ER -