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Ecl1, a regulator of the chronological lifespan of Schizosaccharomyces pombe, is induced upon nitrogen starvation.
Biosci Biotechnol Biochem. 2011; 75(2):279-83.BB

Abstract

In fission yeast, ecl1(+) was identified as a novel factor that extends chronological lifespan when overexpressed. Ecl1 is a small protein consisting of 80 amino acids localized mainly in the nucleus. However, the mechanism by which it affects chronological lifespan has not been elucidated clearly. Here we analyzed the expression profile of Ecl1, especially as to cell cycle and growth phase, and found that it is induced upon nitrogen starvation. Then we analyzed the relevance of factors, Atf1, Ste11, and Tor1, which are known to be involved in the signaling of nitrogen starvation. Though the nitrogen starvation-induced expression of Ecl1 did not change in the atf1Δ mutant, induction in both the ste11Δ mutant and the tor1Δ mutant showed a delay. Based on these observations, the regulation of Ecl1 is discussed.

Authors+Show Affiliations

Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21307597

Citation

Miwa, Yukiko, et al. "Ecl1, a Regulator of the Chronological Lifespan of Schizosaccharomyces Pombe, Is Induced Upon Nitrogen Starvation." Bioscience, Biotechnology, and Biochemistry, vol. 75, no. 2, 2011, pp. 279-83.
Miwa Y, Ohtsuka H, Naito C, et al. Ecl1, a regulator of the chronological lifespan of Schizosaccharomyces pombe, is induced upon nitrogen starvation. Biosci Biotechnol Biochem. 2011;75(2):279-83.
Miwa, Y., Ohtsuka, H., Naito, C., Murakami, H., & Aiba, H. (2011). Ecl1, a regulator of the chronological lifespan of Schizosaccharomyces pombe, is induced upon nitrogen starvation. Bioscience, Biotechnology, and Biochemistry, 75(2), 279-83.
Miwa Y, et al. Ecl1, a Regulator of the Chronological Lifespan of Schizosaccharomyces Pombe, Is Induced Upon Nitrogen Starvation. Biosci Biotechnol Biochem. 2011;75(2):279-83. PubMed PMID: 21307597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ecl1, a regulator of the chronological lifespan of Schizosaccharomyces pombe, is induced upon nitrogen starvation. AU - Miwa,Yukiko, AU - Ohtsuka,Hokuto, AU - Naito,Chikako, AU - Murakami,Hiroshi, AU - Aiba,Hirofumi, Y1 - 2011/02/07/ PY - 2011/2/11/entrez PY - 2011/2/11/pubmed PY - 2011/6/7/medline SP - 279 EP - 83 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 75 IS - 2 N2 - In fission yeast, ecl1(+) was identified as a novel factor that extends chronological lifespan when overexpressed. Ecl1 is a small protein consisting of 80 amino acids localized mainly in the nucleus. However, the mechanism by which it affects chronological lifespan has not been elucidated clearly. Here we analyzed the expression profile of Ecl1, especially as to cell cycle and growth phase, and found that it is induced upon nitrogen starvation. Then we analyzed the relevance of factors, Atf1, Ste11, and Tor1, which are known to be involved in the signaling of nitrogen starvation. Though the nitrogen starvation-induced expression of Ecl1 did not change in the atf1Δ mutant, induction in both the ste11Δ mutant and the tor1Δ mutant showed a delay. Based on these observations, the regulation of Ecl1 is discussed. SN - 1347-6947 UR - https://www.unboundmedicine.com/medline/citation/21307597/Ecl1_a_regulator_of_the_chronological_lifespan_of_Schizosaccharomyces_pombe_is_induced_upon_nitrogen_starvation_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/100607?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -