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The role of experimental models in developing new treatments for irritable bowel syndrome.
Expert Rev Gastroenterol Hepatol. 2011 Feb; 5(1):43-57.ER

Abstract

Irritable bowel syndrome (IBS) is characterized by chronic, recurrent abdominal pain and altered bowel habits and is currently defined by symptom criteria and the absence of detectable organic disease. The underlying pathophysiology remains incompletely understood. Despite considerable efforts by the scientific community and the pharmaceutical industry to develop novel pharmacological treatments aimed at chronic visceral pain, the traditional approach to identifying and evaluating novel drugs for this target have largely failed to translate into effective IBS treatments. However, several novel drugs aimed at normalizing bowel movements have produced clinical effects, not only on the primary target, but also on pain and discomfort. While some of the commonly used experimental animal models for the pain dimension of IBS have some face and construct validity, the predictive validity of most of the models is either unknown, or has been disappointing. A reverse translational approach is proposed, which is based on identification and characterization of brain endophenotypes in patients, followed by translation of these endophenotypes for pharmacological studies in rodent models.

Authors+Show Affiliations

VA Greater Los Angeles Healthcare System, LA, CA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

21309671

Citation

Holschneider, Daniel P., et al. "The Role of Experimental Models in Developing New Treatments for Irritable Bowel Syndrome." Expert Review of Gastroenterology & Hepatology, vol. 5, no. 1, 2011, pp. 43-57.
Holschneider DP, Bradesi S, Mayer EA. The role of experimental models in developing new treatments for irritable bowel syndrome. Expert Rev Gastroenterol Hepatol. 2011;5(1):43-57.
Holschneider, D. P., Bradesi, S., & Mayer, E. A. (2011). The role of experimental models in developing new treatments for irritable bowel syndrome. Expert Review of Gastroenterology & Hepatology, 5(1), 43-57. https://doi.org/10.1586/egh.10.88
Holschneider DP, Bradesi S, Mayer EA. The Role of Experimental Models in Developing New Treatments for Irritable Bowel Syndrome. Expert Rev Gastroenterol Hepatol. 2011;5(1):43-57. PubMed PMID: 21309671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of experimental models in developing new treatments for irritable bowel syndrome. AU - Holschneider,Daniel P, AU - Bradesi,Sylvie, AU - Mayer,Emeran A, PY - 2011/2/12/entrez PY - 2011/2/12/pubmed PY - 2011/7/6/medline SP - 43 EP - 57 JF - Expert review of gastroenterology & hepatology JO - Expert Rev Gastroenterol Hepatol VL - 5 IS - 1 N2 - Irritable bowel syndrome (IBS) is characterized by chronic, recurrent abdominal pain and altered bowel habits and is currently defined by symptom criteria and the absence of detectable organic disease. The underlying pathophysiology remains incompletely understood. Despite considerable efforts by the scientific community and the pharmaceutical industry to develop novel pharmacological treatments aimed at chronic visceral pain, the traditional approach to identifying and evaluating novel drugs for this target have largely failed to translate into effective IBS treatments. However, several novel drugs aimed at normalizing bowel movements have produced clinical effects, not only on the primary target, but also on pain and discomfort. While some of the commonly used experimental animal models for the pain dimension of IBS have some face and construct validity, the predictive validity of most of the models is either unknown, or has been disappointing. A reverse translational approach is proposed, which is based on identification and characterization of brain endophenotypes in patients, followed by translation of these endophenotypes for pharmacological studies in rodent models. SN - 1747-4132 UR - https://www.unboundmedicine.com/medline/citation/21309671/The_role_of_experimental_models_in_developing_new_treatments_for_irritable_bowel_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.1586/egh.10.88 DB - PRIME DP - Unbound Medicine ER -