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Effect of non-surgical treatment on chronic and aggressive periodontitis: clinical, immunologic, and microbiologic findings.
J Periodontol. 2011 Jul; 82(7):979-89.JP

Abstract

BACKGROUND

Our goal was to examine differences in clinical, microbiologic, and immunologic responses to non-surgical mechanical therapy in patients with generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP).

METHODS

Twenty patients with GCP and 14 patients with GAgP were evaluated. Clinical data, gingival crevicular fluid (GCF), and subgingival plaque samples were collected at baseline and 3 months after non-surgical periodontal treatment. Levels of 40 subgingival species were measured using checkerboard DNA-DNA hybridization. GCF interleukin (IL)-1β, -4, and -8 and interferon-γ (IFN-γ) were analyzed using a multiplexed bead immunoassay, and elastase activity was measured using an enzymatic assay. The significance of changes with time was examined using the Wilcoxon rank sum test. Changes in clinical, microbiologic, and immunologic parameters after therapy were compared between groups using the Mann-Whitney U test.

RESULTS

After periodontal therapy, we found significant improvements for all clinical parameters in both groups. We also observed significant reductions in elastase activity in shallow and deep sites from the GAgP group and in deep sites from the GCP group. Microbiologic data showed significant reductions in proportions of orange and red complexes and an increase in proportions of Actinomyces species in both clinical groups. When the clinical, microbiologic, and immunologic responses after therapy were compared between groups, only minor differences were found.

CONCLUSION

This study fails to show any significant differences between severe forms of GCP and GAgP in response to non-surgical periodontal treatment.

Authors+Show Affiliations

Department of Periodontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21309718

Citation

Rosalem, W, et al. "Effect of Non-surgical Treatment On Chronic and Aggressive Periodontitis: Clinical, Immunologic, and Microbiologic Findings." Journal of Periodontology, vol. 82, no. 7, 2011, pp. 979-89.
Rosalem W, Rescala B, Teles RP, et al. Effect of non-surgical treatment on chronic and aggressive periodontitis: clinical, immunologic, and microbiologic findings. J Periodontol. 2011;82(7):979-89.
Rosalem, W., Rescala, B., Teles, R. P., Fischer, R. G., Gustafsson, A., & Figueredo, C. M. (2011). Effect of non-surgical treatment on chronic and aggressive periodontitis: clinical, immunologic, and microbiologic findings. Journal of Periodontology, 82(7), 979-89. https://doi.org/10.1902/jop.2011.100579
Rosalem W, et al. Effect of Non-surgical Treatment On Chronic and Aggressive Periodontitis: Clinical, Immunologic, and Microbiologic Findings. J Periodontol. 2011;82(7):979-89. PubMed PMID: 21309718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of non-surgical treatment on chronic and aggressive periodontitis: clinical, immunologic, and microbiologic findings. AU - Rosalem,W, AU - Rescala,B, AU - Teles,R P, AU - Fischer,R G, AU - Gustafsson,A, AU - Figueredo,C M, Y1 - 2011/02/10/ PY - 2011/2/12/entrez PY - 2011/2/12/pubmed PY - 2012/3/2/medline SP - 979 EP - 89 JF - Journal of periodontology JO - J. Periodontol. VL - 82 IS - 7 N2 - BACKGROUND: Our goal was to examine differences in clinical, microbiologic, and immunologic responses to non-surgical mechanical therapy in patients with generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP). METHODS: Twenty patients with GCP and 14 patients with GAgP were evaluated. Clinical data, gingival crevicular fluid (GCF), and subgingival plaque samples were collected at baseline and 3 months after non-surgical periodontal treatment. Levels of 40 subgingival species were measured using checkerboard DNA-DNA hybridization. GCF interleukin (IL)-1β, -4, and -8 and interferon-γ (IFN-γ) were analyzed using a multiplexed bead immunoassay, and elastase activity was measured using an enzymatic assay. The significance of changes with time was examined using the Wilcoxon rank sum test. Changes in clinical, microbiologic, and immunologic parameters after therapy were compared between groups using the Mann-Whitney U test. RESULTS: After periodontal therapy, we found significant improvements for all clinical parameters in both groups. We also observed significant reductions in elastase activity in shallow and deep sites from the GAgP group and in deep sites from the GCP group. Microbiologic data showed significant reductions in proportions of orange and red complexes and an increase in proportions of Actinomyces species in both clinical groups. When the clinical, microbiologic, and immunologic responses after therapy were compared between groups, only minor differences were found. CONCLUSION: This study fails to show any significant differences between severe forms of GCP and GAgP in response to non-surgical periodontal treatment. SN - 1943-3670 UR - https://www.unboundmedicine.com/medline/citation/21309718/Effect_of_non_surgical_treatment_on_chronic_and_aggressive_periodontitis:_clinical_immunologic_and_microbiologic_findings_ L2 - https://doi.org/10.1902/jop.2011.100579 DB - PRIME DP - Unbound Medicine ER -