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New adolescent polycystic ovary syndrome perspectives.
Minerva Pediatr. 2011 Feb; 63(1):35-47.MP

Abstract

Polycystic ovary syndrome (PCOS) is a common but heterogeneous disorder that usually arises during puberty. This endocrine disorder is associated with chronic anovulation and hyperandrogenemia with clinical manifestation of oligomenorrhea, hirsutism and acne. While the underlying etiology of PCOS remains unknown, it is commonly associated with obesity and insulin resistance leading to increased risk of cardiovascular disease, dyslipidemia and type 2 diabetes mellitus in hyperandrogenemic phenotypes. Menstrual irregularities and insulin resistance in obese adolescents are usually indistinguishable from the clinical manifestations of PCOS and pose a diagnostic dilemma due to higher circulating androgens during puberty. Consequently, a universal consensus on the definition of hyperandrogenemia in adolescents has been elusive. Nevertheless, hyperandrogenemia, independent of obesity, in postmenarchal adolescents is associated with increased risk of cardiometabolic syndrome. Therefore, treatment strategies including lifestyle changes and/or use of insulin-sensitizers, hormone replacement and antiandrogens should be utilized in order to delay long-term cardiovascular and metabolic complications of this endocrinopathy.

Authors+Show Affiliations

Department of Pediatrics, Section of Endocrinology and Diabetes, Medical College of Wisconsin, Milwaukee, WI 53226, USA. ralemzad@mcw.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21311428

Citation

Alemzadeh, R, and A R. Kansra. "New Adolescent Polycystic Ovary Syndrome Perspectives." Minerva Pediatrica, vol. 63, no. 1, 2011, pp. 35-47.
Alemzadeh R, Kansra AR. New adolescent polycystic ovary syndrome perspectives. Minerva Pediatr. 2011;63(1):35-47.
Alemzadeh, R., & Kansra, A. R. (2011). New adolescent polycystic ovary syndrome perspectives. Minerva Pediatrica, 63(1), 35-47.
Alemzadeh R, Kansra AR. New Adolescent Polycystic Ovary Syndrome Perspectives. Minerva Pediatr. 2011;63(1):35-47. PubMed PMID: 21311428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New adolescent polycystic ovary syndrome perspectives. AU - Alemzadeh,R, AU - Kansra,A R, PY - 2011/2/12/entrez PY - 2011/2/12/pubmed PY - 2011/7/23/medline SP - 35 EP - 47 JF - Minerva pediatrica JO - Minerva Pediatr VL - 63 IS - 1 N2 - Polycystic ovary syndrome (PCOS) is a common but heterogeneous disorder that usually arises during puberty. This endocrine disorder is associated with chronic anovulation and hyperandrogenemia with clinical manifestation of oligomenorrhea, hirsutism and acne. While the underlying etiology of PCOS remains unknown, it is commonly associated with obesity and insulin resistance leading to increased risk of cardiovascular disease, dyslipidemia and type 2 diabetes mellitus in hyperandrogenemic phenotypes. Menstrual irregularities and insulin resistance in obese adolescents are usually indistinguishable from the clinical manifestations of PCOS and pose a diagnostic dilemma due to higher circulating androgens during puberty. Consequently, a universal consensus on the definition of hyperandrogenemia in adolescents has been elusive. Nevertheless, hyperandrogenemia, independent of obesity, in postmenarchal adolescents is associated with increased risk of cardiometabolic syndrome. Therefore, treatment strategies including lifestyle changes and/or use of insulin-sensitizers, hormone replacement and antiandrogens should be utilized in order to delay long-term cardiovascular and metabolic complications of this endocrinopathy. SN - 0026-4946 UR - https://www.unboundmedicine.com/medline/citation/21311428/New_adolescent_polycystic_ovary_syndrome_perspectives_ DB - PRIME DP - Unbound Medicine ER -