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Treatment outcome and prognosis of patients with lymph node recurrence of thoracic esophageal squamous cell carcinoma after curative resection.
World J Surg. 2011 Apr; 35(4):798-804.WJ

Abstract

BACKGROUND

This study aimed to assess treatment outcome and factors influencing survival after lymph node recurrence of thoracic esophageal squamous cell carcinoma (SCC) after curative resection.

METHODS

A total of 207 patients who underwent curative resection of thoracic esophageal SCC between March 1999 and March 2009 were retrospectively analyzed. Of these, lymph node recurrence was observed in 45 (21.7%) patients. Twenty-nine patients received intensive treatment (radiation therapy, chemoradiotherapy, or lymphadenectomy) directed at recurrent nodes, 9 patients received chemotherapy, and 7 patients received best supportive care (BSC). Treatment outcome and prognostic factors of these patients were investigated.

RESULTS

Patients who received intensive treatment had significantly higher survival rates after recurrence than those who received chemotherapy or BSC (P = 0.0049 and 0.0004, respectively). In univariate analysis of survival after recurrence, the number of recurrent nodes (a single node or multiple nodes), the region of recurrent nodes (limited to a single region or extended to multiple regions), and the presence of simultaneous organ recurrence (present or absent) were prognostic factors (P = 0.0004, 0.0017, and <0.0001, respectively). Multivariate analysis demonstrated that the region of recurrent nodes and simultaneous organ recurrence were independent prognostic factors (P = 0.0396 and 0.0006, respectively).

CONCLUSIONS

Our findings suggest that the region of recurrent nodes (limited to a single region or extended to multiple regions) and simultaneous organ recurrence are factors influencing survival after lymph node recurrence of thoracic esophageal SCC after curative resection.

Authors+Show Affiliations

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21312037

Citation

Kosuga, Toshiyuki, et al. "Treatment Outcome and Prognosis of Patients With Lymph Node Recurrence of Thoracic Esophageal Squamous Cell Carcinoma After Curative Resection." World Journal of Surgery, vol. 35, no. 4, 2011, pp. 798-804.
Kosuga T, Shiozaki A, Fujiwara H, et al. Treatment outcome and prognosis of patients with lymph node recurrence of thoracic esophageal squamous cell carcinoma after curative resection. World J Surg. 2011;35(4):798-804.
Kosuga, T., Shiozaki, A., Fujiwara, H., Ichikawa, D., Okamoto, K., Komatsu, S., & Otsuji, E. (2011). Treatment outcome and prognosis of patients with lymph node recurrence of thoracic esophageal squamous cell carcinoma after curative resection. World Journal of Surgery, 35(4), 798-804. https://doi.org/10.1007/s00268-011-0978-x
Kosuga T, et al. Treatment Outcome and Prognosis of Patients With Lymph Node Recurrence of Thoracic Esophageal Squamous Cell Carcinoma After Curative Resection. World J Surg. 2011;35(4):798-804. PubMed PMID: 21312037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment outcome and prognosis of patients with lymph node recurrence of thoracic esophageal squamous cell carcinoma after curative resection. AU - Kosuga,Toshiyuki, AU - Shiozaki,Atsushi, AU - Fujiwara,Hitoshi, AU - Ichikawa,Daisuke, AU - Okamoto,Kazuma, AU - Komatsu,Shuhei, AU - Otsuji,Eigo, PY - 2011/2/12/entrez PY - 2011/2/12/pubmed PY - 2011/7/20/medline SP - 798 EP - 804 JF - World journal of surgery JO - World J Surg VL - 35 IS - 4 N2 - BACKGROUND: This study aimed to assess treatment outcome and factors influencing survival after lymph node recurrence of thoracic esophageal squamous cell carcinoma (SCC) after curative resection. METHODS: A total of 207 patients who underwent curative resection of thoracic esophageal SCC between March 1999 and March 2009 were retrospectively analyzed. Of these, lymph node recurrence was observed in 45 (21.7%) patients. Twenty-nine patients received intensive treatment (radiation therapy, chemoradiotherapy, or lymphadenectomy) directed at recurrent nodes, 9 patients received chemotherapy, and 7 patients received best supportive care (BSC). Treatment outcome and prognostic factors of these patients were investigated. RESULTS: Patients who received intensive treatment had significantly higher survival rates after recurrence than those who received chemotherapy or BSC (P = 0.0049 and 0.0004, respectively). In univariate analysis of survival after recurrence, the number of recurrent nodes (a single node or multiple nodes), the region of recurrent nodes (limited to a single region or extended to multiple regions), and the presence of simultaneous organ recurrence (present or absent) were prognostic factors (P = 0.0004, 0.0017, and <0.0001, respectively). Multivariate analysis demonstrated that the region of recurrent nodes and simultaneous organ recurrence were independent prognostic factors (P = 0.0396 and 0.0006, respectively). CONCLUSIONS: Our findings suggest that the region of recurrent nodes (limited to a single region or extended to multiple regions) and simultaneous organ recurrence are factors influencing survival after lymph node recurrence of thoracic esophageal SCC after curative resection. SN - 1432-2323 UR - https://www.unboundmedicine.com/medline/citation/21312037/Treatment_outcome_and_prognosis_of_patients_with_lymph_node_recurrence_of_thoracic_esophageal_squamous_cell_carcinoma_after_curative_resection_ L2 - https://dx.doi.org/10.1007/s00268-011-0978-x DB - PRIME DP - Unbound Medicine ER -