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The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil.
Curr Biol. 2011 Feb 22; 21(4):316-21.CB

Abstract

Mustard oil (MO) is a plant-derived irritant that has been extensively used in experimental models to induce pain and inflammation. The noxious effects of MO are currently ascribed to specific activation of the cation channel TRPA1 in nociceptive neurons. In contrast to this view, we show here that the capsaicin receptor TRPV1 has a surprisingly large contribution to aversive and pain responses and visceral irritation induced by MO. Furthermore, we found that this can be explained by previously unknown properties of this compound. First, MO has a bimodal effect on TRPA1, producing current inhibition at millimolar concentrations. Second, it directly and stably activates mouse and human recombinant TRPV1, as well as TRPV1 channels in mouse sensory neurons. Finally, physiological temperatures enhance MO-induced TRPV1 stimulation. Our results refute the dogma that TRPA1 is the sole nocisensor for MO and motivate a revision of the putative roles of these channels in models of MO-induced pain and inflammation. We propose that TRPV1 has a generalized role in the detection of irritant botanical defensive traits and in the coevolution of multiple mammalian and plant species.

Authors+Show Affiliations

Laboratory for Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, 3000 Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21315593

Citation

Everaerts, Wouter, et al. "The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil." Current Biology : CB, vol. 21, no. 4, 2011, pp. 316-21.
Everaerts W, Gees M, Alpizar YA, et al. The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr Biol. 2011;21(4):316-21.
Everaerts, W., Gees, M., Alpizar, Y. A., Farre, R., Leten, C., Apetrei, A., Dewachter, I., van Leuven, F., Vennekens, R., De Ridder, D., Nilius, B., Voets, T., & Talavera, K. (2011). The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Current Biology : CB, 21(4), 316-21. https://doi.org/10.1016/j.cub.2011.01.031
Everaerts W, et al. The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil. Curr Biol. 2011 Feb 22;21(4):316-21. PubMed PMID: 21315593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. AU - Everaerts,Wouter, AU - Gees,Maarten, AU - Alpizar,Yeranddy A, AU - Farre,Ricard, AU - Leten,Cindy, AU - Apetrei,Aurelia, AU - Dewachter,Ilse, AU - van Leuven,Fred, AU - Vennekens,Rudi, AU - De Ridder,Dirk, AU - Nilius,Bernd, AU - Voets,Thomas, AU - Talavera,Karel, PY - 2010/07/15/received PY - 2010/12/03/revised PY - 2011/01/11/accepted PY - 2011/2/15/entrez PY - 2011/2/15/pubmed PY - 2011/7/20/medline SP - 316 EP - 21 JF - Current biology : CB JO - Curr Biol VL - 21 IS - 4 N2 - Mustard oil (MO) is a plant-derived irritant that has been extensively used in experimental models to induce pain and inflammation. The noxious effects of MO are currently ascribed to specific activation of the cation channel TRPA1 in nociceptive neurons. In contrast to this view, we show here that the capsaicin receptor TRPV1 has a surprisingly large contribution to aversive and pain responses and visceral irritation induced by MO. Furthermore, we found that this can be explained by previously unknown properties of this compound. First, MO has a bimodal effect on TRPA1, producing current inhibition at millimolar concentrations. Second, it directly and stably activates mouse and human recombinant TRPV1, as well as TRPV1 channels in mouse sensory neurons. Finally, physiological temperatures enhance MO-induced TRPV1 stimulation. Our results refute the dogma that TRPA1 is the sole nocisensor for MO and motivate a revision of the putative roles of these channels in models of MO-induced pain and inflammation. We propose that TRPV1 has a generalized role in the detection of irritant botanical defensive traits and in the coevolution of multiple mammalian and plant species. SN - 1879-0445 UR - https://www.unboundmedicine.com/medline/citation/21315593/The_capsaicin_receptor_TRPV1_is_a_crucial_mediator_of_the_noxious_effects_of_mustard_oil_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9822(11)00054-6 DB - PRIME DP - Unbound Medicine ER -