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Effects of resistance and aerobic exercise on physical function, bone mineral density, OPG and RANKL in older women.
Exp Gerontol. 2011 Jul; 46(7):524-32.EG

Abstract

This study compared the effects of a resistance training protocol and a moderate-impact aerobic training protocol on bone mineral density (BMD), physical ability, serum osteoprotegerin (OPG), and receptor activator of nuclear factor kappa B ligand (RANKL) levels. Seventy-one older women were randomly assigned to resistance exercise (RE), aerobic exercise (AE) or a control group (CON). Both interventions were conducted 3 times per week for 8 months. Outcome measures included proximal femur BMD, muscle strength, balance, body composition, serum OPG, and RANKL levels. Potential confounding variables included dietary intake, accelerometer-based physical activity (PA), and molecularly defined lactase nonpersistence. After 8 months, only RE group exhibited increases in BMD at the trochanter (2.9%) and total hip (1.5%), and improved body composition. Both RE and AE groups improved balance. No significant changes were observed in OPG and RANKL levels, and OPG/RANKL ratio. Lactase nonpersistence was not associated with BMD changes. No group differences were observed in baseline values or change in dietary intakes and daily PA. Data suggest that 8 months of RE may be more effective than AE for inducing favourable changes in BMD and muscle strength, whilst both interventions demonstrate to protect against the functional balance control that is strongly related to fall risk.

Authors+Show Affiliations

Research Centre in Physical Activity, Health and Leisure, Faculty of Sport Science, University of Porto, Rua Dr. Plácido Costa 91, 4200-450 Porto, Portugal. elisaamarques@msn.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21316442

Citation

Marques, Elisa A., et al. "Effects of Resistance and Aerobic Exercise On Physical Function, Bone Mineral Density, OPG and RANKL in Older Women." Experimental Gerontology, vol. 46, no. 7, 2011, pp. 524-32.
Marques EA, Wanderley F, Machado L, et al. Effects of resistance and aerobic exercise on physical function, bone mineral density, OPG and RANKL in older women. Exp Gerontol. 2011;46(7):524-32.
Marques, E. A., Wanderley, F., Machado, L., Sousa, F., Viana, J. L., Moreira-Gonçalves, D., Moreira, P., Mota, J., & Carvalho, J. (2011). Effects of resistance and aerobic exercise on physical function, bone mineral density, OPG and RANKL in older women. Experimental Gerontology, 46(7), 524-32. https://doi.org/10.1016/j.exger.2011.02.005
Marques EA, et al. Effects of Resistance and Aerobic Exercise On Physical Function, Bone Mineral Density, OPG and RANKL in Older Women. Exp Gerontol. 2011;46(7):524-32. PubMed PMID: 21316442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of resistance and aerobic exercise on physical function, bone mineral density, OPG and RANKL in older women. AU - Marques,Elisa A, AU - Wanderley,Flávia, AU - Machado,Leandro, AU - Sousa,Filipa, AU - Viana,João L, AU - Moreira-Gonçalves,Daniel, AU - Moreira,Pedro, AU - Mota,Jorge, AU - Carvalho,Joana, Y1 - 2011/02/23/ PY - 2010/11/29/received PY - 2011/01/18/revised PY - 2011/02/01/accepted PY - 2011/2/15/entrez PY - 2011/2/15/pubmed PY - 2011/9/29/medline SP - 524 EP - 32 JF - Experimental gerontology JO - Exp Gerontol VL - 46 IS - 7 N2 - This study compared the effects of a resistance training protocol and a moderate-impact aerobic training protocol on bone mineral density (BMD), physical ability, serum osteoprotegerin (OPG), and receptor activator of nuclear factor kappa B ligand (RANKL) levels. Seventy-one older women were randomly assigned to resistance exercise (RE), aerobic exercise (AE) or a control group (CON). Both interventions were conducted 3 times per week for 8 months. Outcome measures included proximal femur BMD, muscle strength, balance, body composition, serum OPG, and RANKL levels. Potential confounding variables included dietary intake, accelerometer-based physical activity (PA), and molecularly defined lactase nonpersistence. After 8 months, only RE group exhibited increases in BMD at the trochanter (2.9%) and total hip (1.5%), and improved body composition. Both RE and AE groups improved balance. No significant changes were observed in OPG and RANKL levels, and OPG/RANKL ratio. Lactase nonpersistence was not associated with BMD changes. No group differences were observed in baseline values or change in dietary intakes and daily PA. Data suggest that 8 months of RE may be more effective than AE for inducing favourable changes in BMD and muscle strength, whilst both interventions demonstrate to protect against the functional balance control that is strongly related to fall risk. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/21316442/Effects_of_resistance_and_aerobic_exercise_on_physical_function_bone_mineral_density_OPG_and_RANKL_in_older_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(11)00055-6 DB - PRIME DP - Unbound Medicine ER -