Tags

Type your tag names separated by a space and hit enter

Release of theophylline and carbamazepine from matrix tablets--consequences of HPMC chemical heterogeneity.
Eur J Pharm Biopharm. 2011 Aug; 78(3):470-9.EJ

Abstract

The release of theophylline and carbamazepine from matrix tablets composed of microcrystalline cellulose, lactose and hydroxypropyl methylcellulose (HPMC) was studied. The aim was to investigate the effect of different substituent heterogeneities of HPMC on the drug release from matrix tablets composed of either 35% or 45% HPMC. The release of the poorly soluble carbamazepine was considerably affected by the HPMC heterogeneity, and the time difference at 80% drug release was more than 12h between the formulations of different HPMC batches. This was explained by slower polymer erosion of the heterogeneous HPMC and the fact that carbamazepine was mainly released by erosion. In addition, results from magnetic resonance imaging showed that the rate of water transport into the tablets was similar. This explained the comparable results of the release of the sparingly soluble theophylline from the two formulations even though the polymer erosion and the swelling of the tablets were considerably different. Thus, it can be concluded that the drug release was highly affected by the substituent heterogeneity, especially in the case of carbamazepine, which was released mainly by erosion.

Authors+Show Affiliations

Dept. of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. anna.viriden@chalmers.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21316446

Citation

Viridén, Anna, et al. "Release of Theophylline and Carbamazepine From Matrix Tablets--consequences of HPMC Chemical Heterogeneity." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 78, no. 3, 2011, pp. 470-9.
Viridén A, Abrahmsén-Alami S, Wittgren B, et al. Release of theophylline and carbamazepine from matrix tablets--consequences of HPMC chemical heterogeneity. Eur J Pharm Biopharm. 2011;78(3):470-9.
Viridén, A., Abrahmsén-Alami, S., Wittgren, B., & Larsson, A. (2011). Release of theophylline and carbamazepine from matrix tablets--consequences of HPMC chemical heterogeneity. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 78(3), 470-9. https://doi.org/10.1016/j.ejpb.2011.02.003
Viridén A, et al. Release of Theophylline and Carbamazepine From Matrix Tablets--consequences of HPMC Chemical Heterogeneity. Eur J Pharm Biopharm. 2011;78(3):470-9. PubMed PMID: 21316446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Release of theophylline and carbamazepine from matrix tablets--consequences of HPMC chemical heterogeneity. AU - Viridén,Anna, AU - Abrahmsén-Alami,Susanna, AU - Wittgren,Bengt, AU - Larsson,Anette, Y1 - 2011/02/18/ PY - 2010/11/23/received PY - 2011/02/01/revised PY - 2011/02/04/accepted PY - 2011/2/15/entrez PY - 2011/2/15/pubmed PY - 2012/1/25/medline SP - 470 EP - 9 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 78 IS - 3 N2 - The release of theophylline and carbamazepine from matrix tablets composed of microcrystalline cellulose, lactose and hydroxypropyl methylcellulose (HPMC) was studied. The aim was to investigate the effect of different substituent heterogeneities of HPMC on the drug release from matrix tablets composed of either 35% or 45% HPMC. The release of the poorly soluble carbamazepine was considerably affected by the HPMC heterogeneity, and the time difference at 80% drug release was more than 12h between the formulations of different HPMC batches. This was explained by slower polymer erosion of the heterogeneous HPMC and the fact that carbamazepine was mainly released by erosion. In addition, results from magnetic resonance imaging showed that the rate of water transport into the tablets was similar. This explained the comparable results of the release of the sparingly soluble theophylline from the two formulations even though the polymer erosion and the swelling of the tablets were considerably different. Thus, it can be concluded that the drug release was highly affected by the substituent heterogeneity, especially in the case of carbamazepine, which was released mainly by erosion. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/21316446/Release_of_theophylline_and_carbamazepine_from_matrix_tablets__consequences_of_HPMC_chemical_heterogeneity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(11)00054-3 DB - PRIME DP - Unbound Medicine ER -