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Serum complement C3 has a stronger association with insulin resistance than high-sensitivity C-reactive protein in women with polycystic ovary syndrome.

Abstract

OBJECTIVE

To compare the association of complement C3 (C3) versus high-sensitivity C-reactive protein (hs-CRP) with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS).

DESIGN

Cross-sectional analysis.

SETTING

Clinical research center in China.

PATIENT(S)

One hundred thirty-three women with PCOS and 116 healthy, age-matched controls were recruited.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

One hundred one women with PCOS and 20 controls underwent hyperinsulinemic-euglycemic clamp to assess their insulin sensitivity, which was expressed as an M value.

RESULT(S)

Compared with controls, women with PCOS had a lower M value and higher C3 (1.37 ± 0. 34 vs. 1.10 ± 0.22 g/L) and hs-CRP levels (1.46 ± 2.29 vs. 0.49 ± 0.88 mg/L). In women with PCOS, C3 and hs-CRP negatively correlated with M value (r = -0.61 and r = -0.47, respectively). By regression analysis, C3 was found to have a greater impact on the M value (standardized coefficient β = -0.24) than did hs-CRP (standardized coefficient β = -0.13). After adjusting for body mass index (BMI), women with PCOS in the upper quartile were 4.30 times more likely to exhibit IR compared with those in the lower quartiles, whereas hs-CRP was not a statistically significant predictor of IR in women with PCOS.

CONCLUSION(S)

Compared with hs-CRP, serum C3 might be a stronger inflammatory marker of IR in women with PCOS.

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  • Authors+Show Affiliations

    ,

    Department of Endocrinology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

    , , , , , ,

    Source

    Fertility and sterility 95:5 2011 Apr pg 1749-53

    MeSH

    Adult
    Body Composition
    Body Mass Index
    C-Reactive Protein
    Case-Control Studies
    Complement C3
    Cross-Sectional Studies
    Female
    Glucose Clamp Technique
    Humans
    Insulin Resistance
    Polycystic Ovary Syndrome
    Substrate Specificity
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21316661