Tags

Type your tag names separated by a space and hit enter

Alcohol consumption and breast cancer risk in Japanese women: the Miyagi Cohort study.
Breast Cancer Res Treat 2011; 128(3):817-25BC

Abstract

Alcohol consumption is known to be a risk factor for breast cancer in Western countries, but few epidemiologic data have been available in Japan. This population-based prospective cohort study evaluated the associations of alcohol consumption with breast cancer risk in a Japanese population. A total of 19,227 women aged 40-64 years were followed from 1990 to 2003. During 246,703 person-years of follow-up, 241 breast cancer cases were identified. Hazard ratios (HRs) were estimated by the Cox proportional-hazard regression model. After adjustment for potential risk factors of breast cancer and nutritional factors, the HR and 95% confidence interval (CI) for current drinkers was 1.00 (0.74-1.34) compared with never drinkers. According to the amount of alcohol intake per day, a higher amount (≥15.0 g/day) had no significant relation to breast cancer risk (HR = 0.87, 95% CI: 0.40-1.91; P for trend = 0.85). Age upon starting to drink, and the frequency of drinking, were not associated with breast cancer risk. In analysis stratified according to exogenous female hormone use, a higher alcohol intake (≥15.0 g/day) was associated with an increased risk of breast cancer among hormone users (HR = 1.67, 95% CI: 0.17-16.73); however, this was not statistically significant. Stratification according to folate intake with energy adjustment (<219, ≥ 219 μg/day) found that breast cancer risk tended to increase with increasing alcohol consumption among women with a low intake of folate (P for trend = 0.09). Our findings suggest that alcohol consumption has no overall effect on breast cancer risk among Japanese women, whereas nutritional factors such as folate intake may modify the alcohol-breast cancer risk relationship.

Authors+Show Affiliations

Department of Surgical Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21318600

Citation

Kawai, Masaaki, et al. "Alcohol Consumption and Breast Cancer Risk in Japanese Women: the Miyagi Cohort Study." Breast Cancer Research and Treatment, vol. 128, no. 3, 2011, pp. 817-25.
Kawai M, Minami Y, Kakizaki M, et al. Alcohol consumption and breast cancer risk in Japanese women: the Miyagi Cohort study. Breast Cancer Res Treat. 2011;128(3):817-25.
Kawai, M., Minami, Y., Kakizaki, M., Kakugawa, Y., Nishino, Y., Fukao, A., ... Ohuchi, N. (2011). Alcohol consumption and breast cancer risk in Japanese women: the Miyagi Cohort study. Breast Cancer Research and Treatment, 128(3), pp. 817-25. doi:10.1007/s10549-011-1381-x.
Kawai M, et al. Alcohol Consumption and Breast Cancer Risk in Japanese Women: the Miyagi Cohort Study. Breast Cancer Res Treat. 2011;128(3):817-25. PubMed PMID: 21318600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and breast cancer risk in Japanese women: the Miyagi Cohort study. AU - Kawai,Masaaki, AU - Minami,Yuko, AU - Kakizaki,Masako, AU - Kakugawa,Yoichiro, AU - Nishino,Yoshikazu, AU - Fukao,Akira, AU - Tsuji,Ichiro, AU - Ohuchi,Noriaki, Y1 - 2011/02/12/ PY - 2011/01/27/received PY - 2011/01/29/accepted PY - 2011/2/15/entrez PY - 2011/2/15/pubmed PY - 2012/9/14/medline SP - 817 EP - 25 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 128 IS - 3 N2 - Alcohol consumption is known to be a risk factor for breast cancer in Western countries, but few epidemiologic data have been available in Japan. This population-based prospective cohort study evaluated the associations of alcohol consumption with breast cancer risk in a Japanese population. A total of 19,227 women aged 40-64 years were followed from 1990 to 2003. During 246,703 person-years of follow-up, 241 breast cancer cases were identified. Hazard ratios (HRs) were estimated by the Cox proportional-hazard regression model. After adjustment for potential risk factors of breast cancer and nutritional factors, the HR and 95% confidence interval (CI) for current drinkers was 1.00 (0.74-1.34) compared with never drinkers. According to the amount of alcohol intake per day, a higher amount (≥15.0 g/day) had no significant relation to breast cancer risk (HR = 0.87, 95% CI: 0.40-1.91; P for trend = 0.85). Age upon starting to drink, and the frequency of drinking, were not associated with breast cancer risk. In analysis stratified according to exogenous female hormone use, a higher alcohol intake (≥15.0 g/day) was associated with an increased risk of breast cancer among hormone users (HR = 1.67, 95% CI: 0.17-16.73); however, this was not statistically significant. Stratification according to folate intake with energy adjustment (<219, ≥ 219 μg/day) found that breast cancer risk tended to increase with increasing alcohol consumption among women with a low intake of folate (P for trend = 0.09). Our findings suggest that alcohol consumption has no overall effect on breast cancer risk among Japanese women, whereas nutritional factors such as folate intake may modify the alcohol-breast cancer risk relationship. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/21318600/Alcohol_consumption_and_breast_cancer_risk_in_Japanese_women:_the_Miyagi_Cohort_study_ L2 - https://doi.org/10.1007/s10549-011-1381-x DB - PRIME DP - Unbound Medicine ER -