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Alterations in dietary fatty acid composition alter rat brush border membrane phospholipid fatty acid composition.
Diabetes Res. 1990 Aug; 14(4):165-70.DR

Abstract

Female Wistar rats were fed for 8 weeks a high polyunsaturated fatty acid diet (P) enriched with 18:2w6 and 18:3w3, or a high saturated fatty acid diet (S) enriched with 16:0, 18:0 and 18:1w9. There was a similar jejunal BBM fatty acid profile in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) composition in animals fed P. However, feeding S altered the fatty acid composition of BBM phospholipids: for PC, feeding S increased total monounsaturated fatty acids (e.g. 18:1(9)) and reduced total polyunsaturated fatty acids, especially the total w6 fatty acids. For PE, feeding S increased only the total monounsaturated fatty acids. The ratio of monounsaturated/saturated fatty acids was increased for PC and PE. Fatty acid changes were more pronounced in the jejunal than ileal BBM. It is concluded that alterations in dietary fatty acid saturation: (a) influences intestinal BBM phospholipid fatty acid composition; (b) these changes are quantitatively and qualitatively different for PC and PE; and (c) changes are greater in the proximal than in the distal intestine. It is proposed that the previously reported diet-associated changes in active and passive intestinal transport are due at least in part to these alterations in the fatty acid composition in brush border membrane phospholipids.

Authors+Show Affiliations

Department of Medicine, University of Alberta, Edmonton, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2132189

Citation

Keelan, M, et al. "Alterations in Dietary Fatty Acid Composition Alter Rat Brush Border Membrane Phospholipid Fatty Acid Composition." Diabetes Research (Edinburgh, Scotland), vol. 14, no. 4, 1990, pp. 165-70.
Keelan M, Wierzbicki A, Clandinin MT, et al. Alterations in dietary fatty acid composition alter rat brush border membrane phospholipid fatty acid composition. Diabetes Res. 1990;14(4):165-70.
Keelan, M., Wierzbicki, A., Clandinin, M. T., Walker, K., & Thomson, A. B. (1990). Alterations in dietary fatty acid composition alter rat brush border membrane phospholipid fatty acid composition. Diabetes Research (Edinburgh, Scotland), 14(4), 165-70.
Keelan M, et al. Alterations in Dietary Fatty Acid Composition Alter Rat Brush Border Membrane Phospholipid Fatty Acid Composition. Diabetes Res. 1990;14(4):165-70. PubMed PMID: 2132189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in dietary fatty acid composition alter rat brush border membrane phospholipid fatty acid composition. AU - Keelan,M, AU - Wierzbicki,A, AU - Clandinin,M T, AU - Walker,K, AU - Thomson,A B, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 165 EP - 70 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res. VL - 14 IS - 4 N2 - Female Wistar rats were fed for 8 weeks a high polyunsaturated fatty acid diet (P) enriched with 18:2w6 and 18:3w3, or a high saturated fatty acid diet (S) enriched with 16:0, 18:0 and 18:1w9. There was a similar jejunal BBM fatty acid profile in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) composition in animals fed P. However, feeding S altered the fatty acid composition of BBM phospholipids: for PC, feeding S increased total monounsaturated fatty acids (e.g. 18:1(9)) and reduced total polyunsaturated fatty acids, especially the total w6 fatty acids. For PE, feeding S increased only the total monounsaturated fatty acids. The ratio of monounsaturated/saturated fatty acids was increased for PC and PE. Fatty acid changes were more pronounced in the jejunal than ileal BBM. It is concluded that alterations in dietary fatty acid saturation: (a) influences intestinal BBM phospholipid fatty acid composition; (b) these changes are quantitatively and qualitatively different for PC and PE; and (c) changes are greater in the proximal than in the distal intestine. It is proposed that the previously reported diet-associated changes in active and passive intestinal transport are due at least in part to these alterations in the fatty acid composition in brush border membrane phospholipids. SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/2132189/Alterations_in_dietary_fatty_acid_composition_alter_rat_brush_border_membrane_phospholipid_fatty_acid_composition_ L2 - https://medlineplus.gov/dietaryfats.html DB - PRIME DP - Unbound Medicine ER -