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Apolipoprotein and lipid ratios in treated non-insulin dependent diabetics.
Diabetes Res. 1990 Sep; 15(1):21-5.DR

Abstract

Fasting total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL C), apolipoprotein A1 (apo A1) and apolipoprotein B (apo B) were measured in 35 non-insulin dependent diabetic patients treated by diet with or without sulphonylureas and 35 control subjects matched for age, sex, and body mass index. Ratios of apolipoprotein and lipid were calculated. The diabetics were well controlled with a mean (+/- SD) glycosylated haemoglobin (HbA1) of 8.5 +/- 1.3% (normal range less than 8%). Compared to non-diabetic control subjects apo A1: HDL C, apo B: TC, and apo B: calculated LDL C were significantly higher in the NIDDM patients, (112.9 +/- 26.3 vs 83.0 +/- 28.7, p less than 0.001, 15.89 +/- 1.68 vs 14.22 +/- 3.48, p less than 0.01, and 24.32 +/- 3.19 vs 22.33 +/- 5.49, p less than 0.05 respectively). These findings reflect differences in cholesterol content in the absence of differences in apolipoprotein concentrations between the NIDDM and control groups. The cardiovascular risk ratio HDL C: non HDL C was significantly lower in the NIDDM patients (0.25 +/- 0.09 vs 0.31 +/- 0.15, p less than 0.01), but there was no difference in apo A1:apo B (1.42 +/- 0.42 vs 1.43 +/- 0.52, NS). Although apo A1: apo B correlated well with HDL C:non HDL C in both NIDDM and controls (r = 0.88, 0.72, p less than 0.001 respectively) the slope of the relationships differed b = 4.01 NIDDM vs 2.50 controls (95% confidence intervals for difference is 0.22-2.78). Simple widely available methods can identify abnormalities of lipoprotein content in treated NIDDM patients. Both HDL and LDL contain less cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2132196

Citation

Dean, J D., et al. "Apolipoprotein and Lipid Ratios in Treated Non-insulin Dependent Diabetics." Diabetes Research (Edinburgh, Scotland), vol. 15, no. 1, 1990, pp. 21-5.
Dean JD, Owens DR, Matthews SB. Apolipoprotein and lipid ratios in treated non-insulin dependent diabetics. Diabetes Res. 1990;15(1):21-5.
Dean, J. D., Owens, D. R., & Matthews, S. B. (1990). Apolipoprotein and lipid ratios in treated non-insulin dependent diabetics. Diabetes Research (Edinburgh, Scotland), 15(1), 21-5.
Dean JD, Owens DR, Matthews SB. Apolipoprotein and Lipid Ratios in Treated Non-insulin Dependent Diabetics. Diabetes Res. 1990;15(1):21-5. PubMed PMID: 2132196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein and lipid ratios in treated non-insulin dependent diabetics. AU - Dean,J D, AU - Owens,D R, AU - Matthews,S B, PY - 1990/9/1/pubmed PY - 1990/9/1/medline PY - 1990/9/1/entrez SP - 21 EP - 5 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res VL - 15 IS - 1 N2 - Fasting total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL C), apolipoprotein A1 (apo A1) and apolipoprotein B (apo B) were measured in 35 non-insulin dependent diabetic patients treated by diet with or without sulphonylureas and 35 control subjects matched for age, sex, and body mass index. Ratios of apolipoprotein and lipid were calculated. The diabetics were well controlled with a mean (+/- SD) glycosylated haemoglobin (HbA1) of 8.5 +/- 1.3% (normal range less than 8%). Compared to non-diabetic control subjects apo A1: HDL C, apo B: TC, and apo B: calculated LDL C were significantly higher in the NIDDM patients, (112.9 +/- 26.3 vs 83.0 +/- 28.7, p less than 0.001, 15.89 +/- 1.68 vs 14.22 +/- 3.48, p less than 0.01, and 24.32 +/- 3.19 vs 22.33 +/- 5.49, p less than 0.05 respectively). These findings reflect differences in cholesterol content in the absence of differences in apolipoprotein concentrations between the NIDDM and control groups. The cardiovascular risk ratio HDL C: non HDL C was significantly lower in the NIDDM patients (0.25 +/- 0.09 vs 0.31 +/- 0.15, p less than 0.01), but there was no difference in apo A1:apo B (1.42 +/- 0.42 vs 1.43 +/- 0.52, NS). Although apo A1: apo B correlated well with HDL C:non HDL C in both NIDDM and controls (r = 0.88, 0.72, p less than 0.001 respectively) the slope of the relationships differed b = 4.01 NIDDM vs 2.50 controls (95% confidence intervals for difference is 0.22-2.78). Simple widely available methods can identify abnormalities of lipoprotein content in treated NIDDM patients. Both HDL and LDL contain less cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/2132196/Apolipoprotein_and_lipid_ratios_in_treated_non_insulin_dependent_diabetics_ DB - PRIME DP - Unbound Medicine ER -