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Contrast enhancement of extradural compressive material on magnetic resonance imaging.
Vet Radiol Ultrasound. 2011 Jan-Feb; 52(1):10-6.VR

Abstract

Gadolinium-enhancement of compressive extradural material is detected occasionally with magnetic resonance (MR) imaging in dogs. Our goal was to characterize contrast enhancement of extradural compressive material associated with intervertebral disc herniation, and to evaluate the association between enhancement and histopathologic findings and the onset of clinical signs. Ninety-three dogs with a total of 99 lesions diagnosed as intervertebral disc herniation on MR imaging were assessed. Images were evaluated for lesion location, type of herniation, degree of compression, intramedullary T2-weighted (T2W) intensities, and contrast enhancement. In 23 dogs, surgically removed compressive material was evaluated histopathologically for hemorrhage, inflammation, neovascularization, fibroplasia, fibrosis, mineralization, necrosis, and chronicity. Contrast enhancement of extradural compressive material, meninges, and both the compressive materials and meninges was present in 51.5%, 39.4%, and 17.2% of lesions, respectively. Extradural enhancement occurred more frequently in extrusions than protrusions (P = 0.001). Meningeal enhancement and more severe neurologic deficits were significantly associated with a shorter duration of clinical signs (P = 0.04 and 0.01, respectively). Intramedullary T2W hyperintensities, present with 44.4% of lesions, were associated with more severe neurologic deficits (P = 0.001). Lesions with extradural enhancement were more often considered subacute to chronic in duration and more frequently associated with hemorrhage compared with nonenhancing material; however, no statistically significant association was established between contrast enhancement and histopathologic findings. Contrast enhancement of extradural compressive material and the meninges was found to be common with intervertebral disc herniation, and should not be interpreted as a specific sign of a mass lesion such as neoplasia.

Authors+Show Affiliations

Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21322382

Citation

Suran, Jantra Ngosuwan, et al. "Contrast Enhancement of Extradural Compressive Material On Magnetic Resonance Imaging." Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, vol. 52, no. 1, 2011, pp. 10-6.
Suran JN, Durham A, Mai W, et al. Contrast enhancement of extradural compressive material on magnetic resonance imaging. Vet Radiol Ultrasound. 2011;52(1):10-6.
Suran, J. N., Durham, A., Mai, W., & Seiler, G. S. (2011). Contrast enhancement of extradural compressive material on magnetic resonance imaging. Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 52(1), 10-6.
Suran JN, et al. Contrast Enhancement of Extradural Compressive Material On Magnetic Resonance Imaging. Vet Radiol Ultrasound. 2011 Jan-Feb;52(1):10-6. PubMed PMID: 21322382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contrast enhancement of extradural compressive material on magnetic resonance imaging. AU - Suran,Jantra Ngosuwan, AU - Durham,Amy, AU - Mai,Wilfried, AU - Seiler,Gabriela S, PY - 2011/2/17/entrez PY - 2011/2/17/pubmed PY - 2011/3/11/medline SP - 10 EP - 6 JF - Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association JO - Vet Radiol Ultrasound VL - 52 IS - 1 N2 - Gadolinium-enhancement of compressive extradural material is detected occasionally with magnetic resonance (MR) imaging in dogs. Our goal was to characterize contrast enhancement of extradural compressive material associated with intervertebral disc herniation, and to evaluate the association between enhancement and histopathologic findings and the onset of clinical signs. Ninety-three dogs with a total of 99 lesions diagnosed as intervertebral disc herniation on MR imaging were assessed. Images were evaluated for lesion location, type of herniation, degree of compression, intramedullary T2-weighted (T2W) intensities, and contrast enhancement. In 23 dogs, surgically removed compressive material was evaluated histopathologically for hemorrhage, inflammation, neovascularization, fibroplasia, fibrosis, mineralization, necrosis, and chronicity. Contrast enhancement of extradural compressive material, meninges, and both the compressive materials and meninges was present in 51.5%, 39.4%, and 17.2% of lesions, respectively. Extradural enhancement occurred more frequently in extrusions than protrusions (P = 0.001). Meningeal enhancement and more severe neurologic deficits were significantly associated with a shorter duration of clinical signs (P = 0.04 and 0.01, respectively). Intramedullary T2W hyperintensities, present with 44.4% of lesions, were associated with more severe neurologic deficits (P = 0.001). Lesions with extradural enhancement were more often considered subacute to chronic in duration and more frequently associated with hemorrhage compared with nonenhancing material; however, no statistically significant association was established between contrast enhancement and histopathologic findings. Contrast enhancement of extradural compressive material and the meninges was found to be common with intervertebral disc herniation, and should not be interpreted as a specific sign of a mass lesion such as neoplasia. SN - 1058-8183 UR - https://www.unboundmedicine.com/medline/citation/21322382/Contrast_enhancement_of_extradural_compressive_material_on_magnetic_resonance_imaging_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=21322382.ui DB - PRIME DP - Unbound Medicine ER -