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Monitoring of the h275y mutation in pandemic influenza A(H1N1) 2009 strains isolated in Malaysia.

Abstract

Abstract. The 2009 pandemic influenza A(H1N1) infection in Malaysia was first reported in May 2009 and oseltamivir was advocated for confirmed cases in postexposure prophylaxis. However, there are cases of oseltamivir-resistance reported among H1N1-positive patients in other countries. Resistance is due to substitution of histidine by tyrosine at residue 275 (H275Y) of neuraminidase (NA). In this study, we have employed Sanger sequencing method to investigate the occurrence of mutations in NA segments of 67 pandemic 2009 A(H1N1) viral isolates from Malaysian patients that could lead to probable oseltamivir resistance. The sequencing analysis did not yield mutation at residue 275 for all 67 isolates indicating that our viral isolates belong to the wild type and do not confer resistance to oseltamivir.

Authors+Show Affiliations

Virology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia. jeyanthi@imr.gov.myNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21323171

Citation

Suppiah, Jeyanthi, et al. "Monitoring of the H275y Mutation in Pandemic Influenza A(H1N1) 2009 Strains Isolated in Malaysia." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 42, no. 1, 2011, pp. 100-4.
Suppiah J, Yusof MA, Othman KA, et al. Monitoring of the h275y mutation in pandemic influenza A(H1N1) 2009 strains isolated in Malaysia. Southeast Asian J Trop Med Public Health. 2011;42(1):100-4.
Suppiah, J., Yusof, M. A., Othman, K. A., Saraswathy, T. S., Thayan, R., Kasim, F. M., ... Saat, Z. (2011). Monitoring of the h275y mutation in pandemic influenza A(H1N1) 2009 strains isolated in Malaysia. The Southeast Asian Journal of Tropical Medicine and Public Health, 42(1), pp. 100-4.
Suppiah J, et al. Monitoring of the H275y Mutation in Pandemic Influenza A(H1N1) 2009 Strains Isolated in Malaysia. Southeast Asian J Trop Med Public Health. 2011;42(1):100-4. PubMed PMID: 21323171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monitoring of the h275y mutation in pandemic influenza A(H1N1) 2009 strains isolated in Malaysia. AU - Suppiah,Jeyanthi, AU - Yusof,Mohd Apandi, AU - Othman,Khairul Azuan, AU - Saraswathy,T S, AU - Thayan,Ravindran, AU - Kasim,Fauziah M, AU - Murad,Shahnaz, AU - Saat,Zainah, PY - 2011/2/18/entrez PY - 2011/2/18/pubmed PY - 2011/4/8/medline SP - 100 EP - 4 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J. Trop. Med. Public Health VL - 42 IS - 1 N2 - Abstract. The 2009 pandemic influenza A(H1N1) infection in Malaysia was first reported in May 2009 and oseltamivir was advocated for confirmed cases in postexposure prophylaxis. However, there are cases of oseltamivir-resistance reported among H1N1-positive patients in other countries. Resistance is due to substitution of histidine by tyrosine at residue 275 (H275Y) of neuraminidase (NA). In this study, we have employed Sanger sequencing method to investigate the occurrence of mutations in NA segments of 67 pandemic 2009 A(H1N1) viral isolates from Malaysian patients that could lead to probable oseltamivir resistance. The sequencing analysis did not yield mutation at residue 275 for all 67 isolates indicating that our viral isolates belong to the wild type and do not confer resistance to oseltamivir. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/21323171/Monitoring_of_the_h275y_mutation_in_pandemic_influenza_A_H1N1__2009_strains_isolated_in_Malaysia_ L2 - https://medlineplus.gov/flu.html DB - PRIME DP - Unbound Medicine ER -