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Rapid restoration of normoglycaemia using intravenous insulin boluses.
Diabetes Res. 1990 Dec; 15(4):151-5.DR

Abstract

The reduction of elevated fasting plasma glucose levels to near normal by repeated intravenous bolus insulin doses, given according to a simple algorithm, has been studied in 17 Type I and 23 Type II, healthy diabetic patients. Using a formula based on the patient's plasma glucose, height and bodyweight with insulin boluses given every 30 min if the plasma glucose remained above 6 mmol/1, plasma glucose levels were reduced to less than 7.5 mmol/1 in 28 (70%) patients by 60 min at which time the mean (+/- 1 SD) plasma glucose level in the Type I diabetic patients had reduced from 18.2 +/- 4.9 to 8.9 +/- 3.5 mmol/1 and in the Type II diabetic patients from 12.3 +/- 3.1 to 5.9 +/- 1.4 mmol/1. None of the patients had symptomatic hypoglycaemia although in one Type I patient the plasma glucose level fell to 2.2 mmol/1. The rate of fall of glucose in the less insulin sensitive patients was not increased by giving more insulin. The regimen allows a reproducible and prompt glycaemic reduction in fasting diabetic patients.

Authors+Show Affiliations

Nuffield Department of Anaesthetics, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2132403

Citation

Dunnett, J M., et al. "Rapid Restoration of Normoglycaemia Using Intravenous Insulin Boluses." Diabetes Research (Edinburgh, Scotland), vol. 15, no. 4, 1990, pp. 151-5.
Dunnett JM, Steemson J, Sear JW, et al. Rapid restoration of normoglycaemia using intravenous insulin boluses. Diabetes Res. 1990;15(4):151-5.
Dunnett, J. M., Steemson, J., Sear, J. W., Turner, R. C., & Holman, R. R. (1990). Rapid restoration of normoglycaemia using intravenous insulin boluses. Diabetes Research (Edinburgh, Scotland), 15(4), 151-5.
Dunnett JM, et al. Rapid Restoration of Normoglycaemia Using Intravenous Insulin Boluses. Diabetes Res. 1990;15(4):151-5. PubMed PMID: 2132403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid restoration of normoglycaemia using intravenous insulin boluses. AU - Dunnett,J M, AU - Steemson,J, AU - Sear,J W, AU - Turner,R C, AU - Holman,R R, PY - 1990/12/1/pubmed PY - 1990/12/1/medline PY - 1990/12/1/entrez SP - 151 EP - 5 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res VL - 15 IS - 4 N2 - The reduction of elevated fasting plasma glucose levels to near normal by repeated intravenous bolus insulin doses, given according to a simple algorithm, has been studied in 17 Type I and 23 Type II, healthy diabetic patients. Using a formula based on the patient's plasma glucose, height and bodyweight with insulin boluses given every 30 min if the plasma glucose remained above 6 mmol/1, plasma glucose levels were reduced to less than 7.5 mmol/1 in 28 (70%) patients by 60 min at which time the mean (+/- 1 SD) plasma glucose level in the Type I diabetic patients had reduced from 18.2 +/- 4.9 to 8.9 +/- 3.5 mmol/1 and in the Type II diabetic patients from 12.3 +/- 3.1 to 5.9 +/- 1.4 mmol/1. None of the patients had symptomatic hypoglycaemia although in one Type I patient the plasma glucose level fell to 2.2 mmol/1. The rate of fall of glucose in the less insulin sensitive patients was not increased by giving more insulin. The regimen allows a reproducible and prompt glycaemic reduction in fasting diabetic patients. SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/2132403/Rapid_restoration_of_normoglycaemia_using_intravenous_insulin_boluses_ DB - PRIME DP - Unbound Medicine ER -