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Plasma antioxidants and coronary heart disease: vitamins C and E, and selenium.
Eur J Clin Nutr. 1990 Feb; 44(2):143-50.EJ

Abstract

The possibility of a relation between plasma antioxidants such as vitamins C and E and selenium, and mortality from coronary heart disease (CHD) was examined. A cross-sectional survey was undertaken of random population samples of apparently healthy middle-aged men in four European regions with differing mortalities from CHD [rate/100,000 for men aged 40-49]: north Karelia (eastern Finland) (n = 99) [212/100,000]; south-west Finland (n = 85) [146/100,000]; Scotland (n = 131) [140/100,000]; and south Italy (n = 80) [43/100,000]. Median (5th-95th percentile) plasma vitamin C concentrations were lower in Scotland: 18.2 (5.7-61.3) microM than in other regions: north Karelia 28.4 (6.2-85.2); south-west Finland 33.5 (5.7-76.6); south Italy 38.0 (10.2-69.8) microM (P less than 0.001). The median levels in the four areas did not however reflect the regional CHD mortality rates. Regional differences in plasma vitamin E levels were also observed: Scottish levels were low 20.0 (12.1-29.3) microM (P less than 0.001) and did not differ between the other areas: 23.0 (16.7-35.1), 22.5 (13.7-31.6) and 23.9 (15.6-41.3) microM respectively. The vitamin E gradient could be explained in part by differences in serum cholesterol. However, cholesterol-adjusted vitamin E levels were low in the three high CHD areas: Scotland 3.41 (2.41-4.62); north Karelia 3.53 (2.67-5.18); south-west Finland 3.53 (2.58-4.92); Italy 4.81 (3.25-5.99) mumol/mmol cholesterol (P less than 0.001). Cholesterol-adjusted vitamin E was not lower in north Karelia, the higher CHD mortality area in Finland. Serum selenium values also varied with the area examined and reported low levels in Finland were confirmed. Nevertheless, selenium levels did not correlate with the reported mortality rates of CHD. Thus in our small cross-cultural study the evidence did not support our hypothesis that plasma antioxidants explain regional differences in CHD mortality.

Authors+Show Affiliations

Riemersma RA
BHF Cardiovascular Research Unit, University of Edinburgh, Scotland.
Oliver M
No affiliation info available
Elton RA
No affiliation info available
Alfthan G
No affiliation info available
Vartiainen E
No affiliation info available
Salo M
No affiliation info available
Rubba P
No affiliation info available
Mancini M
No affiliation info available
Georgi H
No affiliation info available
Vuilleumier JP
No affiliation info available

MeSH

Adipose TissueAdultAntioxidantsAscorbic AcidCoronary DiseaseCross-Cultural ComparisonCross-Sectional StudiesFinlandHumansItalyLinoleic AcidsMaleMiddle AgedRegression AnalysisRisk FactorsScotlandSeleniumVitamin E

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2132414

Citation

Riemersma, R A., et al. "Plasma Antioxidants and Coronary Heart Disease: Vitamins C and E, and Selenium." European Journal of Clinical Nutrition, vol. 44, no. 2, 1990, pp. 143-50.
Riemersma RA, Oliver M, Elton RA, et al. Plasma antioxidants and coronary heart disease: vitamins C and E, and selenium. Eur J Clin Nutr. 1990;44(2):143-50.
Riemersma, R. A., Oliver, M., Elton, R. A., Alfthan, G., Vartiainen, E., Salo, M., Rubba, P., Mancini, M., Georgi, H., & Vuilleumier, J. P. (1990). Plasma antioxidants and coronary heart disease: vitamins C and E, and selenium. European Journal of Clinical Nutrition, 44(2), 143-50.
Riemersma RA, et al. Plasma Antioxidants and Coronary Heart Disease: Vitamins C and E, and Selenium. Eur J Clin Nutr. 1990;44(2):143-50. PubMed PMID: 2132414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma antioxidants and coronary heart disease: vitamins C and E, and selenium. A1 - Riemersma,R A, AU - Oliver,M, AU - Elton,R A, AU - Alfthan,G, AU - Vartiainen,E, AU - Salo,M, AU - Rubba,P, AU - Mancini,M, AU - Georgi,H, AU - Vuilleumier,J P, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - 143 EP - 50 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 44 IS - 2 N2 - The possibility of a relation between plasma antioxidants such as vitamins C and E and selenium, and mortality from coronary heart disease (CHD) was examined. A cross-sectional survey was undertaken of random population samples of apparently healthy middle-aged men in four European regions with differing mortalities from CHD [rate/100,000 for men aged 40-49]: north Karelia (eastern Finland) (n = 99) [212/100,000]; south-west Finland (n = 85) [146/100,000]; Scotland (n = 131) [140/100,000]; and south Italy (n = 80) [43/100,000]. Median (5th-95th percentile) plasma vitamin C concentrations were lower in Scotland: 18.2 (5.7-61.3) microM than in other regions: north Karelia 28.4 (6.2-85.2); south-west Finland 33.5 (5.7-76.6); south Italy 38.0 (10.2-69.8) microM (P less than 0.001). The median levels in the four areas did not however reflect the regional CHD mortality rates. Regional differences in plasma vitamin E levels were also observed: Scottish levels were low 20.0 (12.1-29.3) microM (P less than 0.001) and did not differ between the other areas: 23.0 (16.7-35.1), 22.5 (13.7-31.6) and 23.9 (15.6-41.3) microM respectively. The vitamin E gradient could be explained in part by differences in serum cholesterol. However, cholesterol-adjusted vitamin E levels were low in the three high CHD areas: Scotland 3.41 (2.41-4.62); north Karelia 3.53 (2.67-5.18); south-west Finland 3.53 (2.58-4.92); Italy 4.81 (3.25-5.99) mumol/mmol cholesterol (P less than 0.001). Cholesterol-adjusted vitamin E was not lower in north Karelia, the higher CHD mortality area in Finland. Serum selenium values also varied with the area examined and reported low levels in Finland were confirmed. Nevertheless, selenium levels did not correlate with the reported mortality rates of CHD. Thus in our small cross-cultural study the evidence did not support our hypothesis that plasma antioxidants explain regional differences in CHD mortality. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/2132414/Plasma_antioxidants_and_coronary_heart_disease:_vitamins_C_and_E_and_selenium_ DB - PRIME DP - Unbound Medicine ER -