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Meta-analysis: Circulating vitamin D and ovarian cancer risk.
Gynecol Oncol 2011; 121(2):369-75GO

Abstract

OBJECTIVE

To review and summarize evidence from longitudinal studies on the association between circulating 25 hydroxyvitamin D (25(OH)D) and the risk of ovarian cancer (OC).

METHODS

Relevant prospective cohort studies and nested case-control studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases and by cross-referencing. The following data were extracted in a standardized manner from eligible studies: first author, publication year, country, study design, characteristics of the study population, duration of follow-up, OC incidence according to circulating vitamin D status and the respective relative risks, and covariates adjusted for in the analysis. Due to the heterogeneity of studies in categorizing circulating vitamin D levels, all results were recalculated for an increase of circulating 25(OH)D by 20ng/ml. Summary relative risks (RRs) were calculated using meta-analysis methods.

RESULTS

Overall, ten individual-level studies were included that reported on the association between circulating vitamin D levels and OC incidence. Meta-analysis of studies on OC incidence resulted in a summary RR (95% confidence interval, CI) of 0.83 (0.63-1.08) for an increase of 25(OH)D by 20ng/ml (P=0.160). No indication for heterogeneity and publication bias was found.

CONCLUSIONS

A tentative inverse association of circulating 25(OH)D with OC incidence was found, which did not reach statistical significance but which requires clarification by additional studies due to potentially high clinical and public health impact.

Authors+Show Affiliations

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D-69115 Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21324518

Citation

Yin, Lu, et al. "Meta-analysis: Circulating Vitamin D and Ovarian Cancer Risk." Gynecologic Oncology, vol. 121, no. 2, 2011, pp. 369-75.
Yin L, Grandi N, Raum E, et al. Meta-analysis: Circulating vitamin D and ovarian cancer risk. Gynecol Oncol. 2011;121(2):369-75.
Yin, L., Grandi, N., Raum, E., Haug, U., Arndt, V., & Brenner, H. (2011). Meta-analysis: Circulating vitamin D and ovarian cancer risk. Gynecologic Oncology, 121(2), pp. 369-75. doi:10.1016/j.ygyno.2011.01.023.
Yin L, et al. Meta-analysis: Circulating Vitamin D and Ovarian Cancer Risk. Gynecol Oncol. 2011 May 1;121(2):369-75. PubMed PMID: 21324518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis: Circulating vitamin D and ovarian cancer risk. AU - Yin,Lu, AU - Grandi,Norma, AU - Raum,Elke, AU - Haug,Ulrike, AU - Arndt,Volker, AU - Brenner,Hermann, Y1 - 2011/02/15/ PY - 2010/12/13/received PY - 2011/01/18/revised PY - 2011/01/19/accepted PY - 2011/2/18/entrez PY - 2011/2/18/pubmed PY - 2011/6/15/medline SP - 369 EP - 75 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 121 IS - 2 N2 - OBJECTIVE: To review and summarize evidence from longitudinal studies on the association between circulating 25 hydroxyvitamin D (25(OH)D) and the risk of ovarian cancer (OC). METHODS: Relevant prospective cohort studies and nested case-control studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases and by cross-referencing. The following data were extracted in a standardized manner from eligible studies: first author, publication year, country, study design, characteristics of the study population, duration of follow-up, OC incidence according to circulating vitamin D status and the respective relative risks, and covariates adjusted for in the analysis. Due to the heterogeneity of studies in categorizing circulating vitamin D levels, all results were recalculated for an increase of circulating 25(OH)D by 20ng/ml. Summary relative risks (RRs) were calculated using meta-analysis methods. RESULTS: Overall, ten individual-level studies were included that reported on the association between circulating vitamin D levels and OC incidence. Meta-analysis of studies on OC incidence resulted in a summary RR (95% confidence interval, CI) of 0.83 (0.63-1.08) for an increase of 25(OH)D by 20ng/ml (P=0.160). No indication for heterogeneity and publication bias was found. CONCLUSIONS: A tentative inverse association of circulating 25(OH)D with OC incidence was found, which did not reach statistical significance but which requires clarification by additional studies due to potentially high clinical and public health impact. SN - 1095-6859 UR - https://www.unboundmedicine.com/medline/citation/21324518/Meta_analysis:_Circulating_vitamin_D_and_ovarian_cancer_risk_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(11)00067-9 DB - PRIME DP - Unbound Medicine ER -