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Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes.
J Clin Endocrinol Metab. 2011 May; 96(5):E830-5.JC

Abstract

CONTEXT

Vitamin D (Vit-D) deficiency is associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear.

OBJECTIVE

We aimed to investigate the cross-sectional association of Vit-D status with brachial flow-mediated dilation (FMD) and circulating endothelial progenitor cell (EPC) numbers in type 2 DM patients.

DESIGN, SETTING, AND PARTICIPANTS

We conducted a cross-sectional study of 280 patients (59% male, aged 68 ± 10 yr) with type 2 DM recruited in outpatient clinics during the winter period.

MAIN OUTCOME MEASURE

We measured serum 25-hydroxyvitamin D [25(OH)D] by an ELISA kit, circulating CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR+ EPCs by flow cytometry and brachial artery FMD by vascular ultrasound, respectively.

RESULTS

The mean serum 25(OH)D concentration was 25.00 ± 9.17 ng/ml, and 34.3% of patients had Vit-D deficiency [25(OH)D < 20 ng/ml]. Serum 25(OH)D concentration had a significant correlation with hemoglobin A1c level [B = -0.018, 95% confidence interval (CI) -0.035 to -0.002, P = 0.032]. Patients with Vit-D deficiency status had significantly lower brachial FMD (mean difference -1.43%, 95% CI -2.31 to -0.55, P = 0.001) and CD133+/KDR+EPC counts (mean difference -0.12%, 95% CI -0.21 to -0.019, P = 0.022) than those with sufficient Vit-D status after adjustment for age, sex, and cardiovascular risk factors, including hemoglobin A1c levels.

CONCLUSIONS

Our results demonstrate that serum 25(OH)D status was significantly associated with brachial artery FMD and circulating CD133+/KDR+EPCs. This suggests that Vit-D deficiency might contribute to depletion of EPCs and endothelial dysfunction in patients with type 2 DM.

Authors+Show Affiliations

Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21325459

Citation

Yiu, Yuen-Fung, et al. "Vitamin D Deficiency Is Associated With Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients With Type 2 Diabetes." The Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 5, 2011, pp. E830-5.
Yiu YF, Chan YH, Yiu KH, et al. Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J Clin Endocrinol Metab. 2011;96(5):E830-5.
Yiu, Y. F., Chan, Y. H., Yiu, K. H., Siu, C. W., Li, S. W., Wong, L. Y., Lee, S. W., Tam, S., Wong, E. W., Cheung, B. M., & Tse, H. F. (2011). Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism, 96(5), E830-5. https://doi.org/10.1210/jc.2010-2212
Yiu YF, et al. Vitamin D Deficiency Is Associated With Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients With Type 2 Diabetes. J Clin Endocrinol Metab. 2011;96(5):E830-5. PubMed PMID: 21325459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. AU - Yiu,Yuen-Fung, AU - Chan,Yap-Hang, AU - Yiu,Kai-Hang, AU - Siu,Chung-Wah, AU - Li,Sheung-Wai, AU - Wong,Lai-Yung, AU - Lee,Stephen W L, AU - Tam,Sidney, AU - Wong,Eric W K, AU - Cheung,Bernard M Y, AU - Tse,Hung-Fat, Y1 - 2011/02/16/ PY - 2011/2/18/entrez PY - 2011/2/18/pubmed PY - 2011/7/1/medline SP - E830 EP - 5 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 96 IS - 5 N2 - CONTEXT: Vitamin D (Vit-D) deficiency is associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear. OBJECTIVE: We aimed to investigate the cross-sectional association of Vit-D status with brachial flow-mediated dilation (FMD) and circulating endothelial progenitor cell (EPC) numbers in type 2 DM patients. DESIGN, SETTING, AND PARTICIPANTS: We conducted a cross-sectional study of 280 patients (59% male, aged 68 ± 10 yr) with type 2 DM recruited in outpatient clinics during the winter period. MAIN OUTCOME MEASURE: We measured serum 25-hydroxyvitamin D [25(OH)D] by an ELISA kit, circulating CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR+ EPCs by flow cytometry and brachial artery FMD by vascular ultrasound, respectively. RESULTS: The mean serum 25(OH)D concentration was 25.00 ± 9.17 ng/ml, and 34.3% of patients had Vit-D deficiency [25(OH)D < 20 ng/ml]. Serum 25(OH)D concentration had a significant correlation with hemoglobin A1c level [B = -0.018, 95% confidence interval (CI) -0.035 to -0.002, P = 0.032]. Patients with Vit-D deficiency status had significantly lower brachial FMD (mean difference -1.43%, 95% CI -2.31 to -0.55, P = 0.001) and CD133+/KDR+EPC counts (mean difference -0.12%, 95% CI -0.21 to -0.019, P = 0.022) than those with sufficient Vit-D status after adjustment for age, sex, and cardiovascular risk factors, including hemoglobin A1c levels. CONCLUSIONS: Our results demonstrate that serum 25(OH)D status was significantly associated with brachial artery FMD and circulating CD133+/KDR+EPCs. This suggests that Vit-D deficiency might contribute to depletion of EPCs and endothelial dysfunction in patients with type 2 DM. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/21325459/Vitamin_D_deficiency_is_associated_with_depletion_of_circulating_endothelial_progenitor_cells_and_endothelial_dysfunction_in_patients_with_type_2_diabetes_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2010-2212 DB - PRIME DP - Unbound Medicine ER -