Tags

Type your tag names separated by a space and hit enter

Intake of vegetables, fruits, carotenoids and vitamins C and E and pancreatic cancer risk in The Netherlands Cohort Study.

Abstract

Epidemiological data investigating the relation between fruit and vegetable consumption and pancreatic cancer risk have shown inconsistent results so far. Most case-control studies observed an inverse association with total fruit and vegetable consumption, whereas results from most cohort studies have largely been null. We examined prospectively the relation between pancreatic cancer risk and intake of vegetables, fruits, carotenoids and vitamins C and E. The Netherlands Cohort Study consisted of 120,852 men and women who completed a questionnaire at baseline in 1986, including a validated 150-item food-frequency questionnaire. After 16.3 years of follow-up, 423 cases were available for analysis. Total vegetable and total fruit consumption were not associated with pancreatic cancer risk (highest vs. lowest quintile, multivariable-adjusted hazard rate ratio = 1.23, 95% confidence interval: 0.86-1.75 and multivariable-adjusted hazard rate ratio = 0.90, 95% confidence interval: 0.66-1.24, respectively). Also, for cooked vegetables, raw vegetables and vegetables and fruits classified into subgroups, no associations were observed. Dietary carotenoids, vitamin C and E intake and supplements containing vitamin C or E were not associated with pancreatic cancer risk. The results were not modified by sex, smoking status and body mass index. In conclusion, we observed no association between a high consumption of vegetables and fruits and pancreatic cancer risk in this large cohort study, which is in agreement with previous prospective studies. Furthermore, we observed no association between the intake of carotenoids, vitamins and vitamin supplements and pancreatic cancer risk.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre+, Maastricht, The Netherlands. mirjam.heinen@maastrichtuniversity.nl

    , ,

    Source

    International journal of cancer 130:1 2012 Jan 01 pg 147-58

    MeSH

    Ascorbic Acid
    Carotenoids
    Case-Control Studies
    Cohort Studies
    Diet Records
    Dietary Supplements
    Female
    Follow-Up Studies
    Fruit
    Health Surveys
    Humans
    Male
    Middle Aged
    Netherlands
    Pancreatic Neoplasms
    Prognosis
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Vegetables
    Vitamin E
    Vitamins

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    21328344

    Citation

    Heinen, Mirjam M., et al. "Intake of Vegetables, Fruits, Carotenoids and Vitamins C and E and Pancreatic Cancer Risk in the Netherlands Cohort Study." International Journal of Cancer, vol. 130, no. 1, 2012, pp. 147-58.
    Heinen MM, Verhage BA, Goldbohm RA, et al. Intake of vegetables, fruits, carotenoids and vitamins C and E and pancreatic cancer risk in The Netherlands Cohort Study. Int J Cancer. 2012;130(1):147-58.
    Heinen, M. M., Verhage, B. A., Goldbohm, R. A., & van den Brandt, P. A. (2012). Intake of vegetables, fruits, carotenoids and vitamins C and E and pancreatic cancer risk in The Netherlands Cohort Study. International Journal of Cancer, 130(1), pp. 147-58. doi:10.1002/ijc.25989.
    Heinen MM, et al. Intake of Vegetables, Fruits, Carotenoids and Vitamins C and E and Pancreatic Cancer Risk in the Netherlands Cohort Study. Int J Cancer. 2012 Jan 1;130(1):147-58. PubMed PMID: 21328344.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of vegetables, fruits, carotenoids and vitamins C and E and pancreatic cancer risk in The Netherlands Cohort Study. AU - Heinen,Mirjam M, AU - Verhage,Bas A J, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, Y1 - 2011/04/27/ PY - 2010/09/13/received PY - 2011/01/26/accepted PY - 2011/2/18/entrez PY - 2011/2/18/pubmed PY - 2011/12/21/medline SP - 147 EP - 58 JF - International journal of cancer JO - Int. J. Cancer VL - 130 IS - 1 N2 - Epidemiological data investigating the relation between fruit and vegetable consumption and pancreatic cancer risk have shown inconsistent results so far. Most case-control studies observed an inverse association with total fruit and vegetable consumption, whereas results from most cohort studies have largely been null. We examined prospectively the relation between pancreatic cancer risk and intake of vegetables, fruits, carotenoids and vitamins C and E. The Netherlands Cohort Study consisted of 120,852 men and women who completed a questionnaire at baseline in 1986, including a validated 150-item food-frequency questionnaire. After 16.3 years of follow-up, 423 cases were available for analysis. Total vegetable and total fruit consumption were not associated with pancreatic cancer risk (highest vs. lowest quintile, multivariable-adjusted hazard rate ratio = 1.23, 95% confidence interval: 0.86-1.75 and multivariable-adjusted hazard rate ratio = 0.90, 95% confidence interval: 0.66-1.24, respectively). Also, for cooked vegetables, raw vegetables and vegetables and fruits classified into subgroups, no associations were observed. Dietary carotenoids, vitamin C and E intake and supplements containing vitamin C or E were not associated with pancreatic cancer risk. The results were not modified by sex, smoking status and body mass index. In conclusion, we observed no association between a high consumption of vegetables and fruits and pancreatic cancer risk in this large cohort study, which is in agreement with previous prospective studies. Furthermore, we observed no association between the intake of carotenoids, vitamins and vitamin supplements and pancreatic cancer risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21328344/Intake_of_vegetables_fruits_carotenoids_and_vitamins_C_and_E_and_pancreatic_cancer_risk_in_The_Netherlands_Cohort_Study_ L2 - https://doi.org/10.1002/ijc.25989 DB - PRIME DP - Unbound Medicine ER -