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Intake of vegetables, fruits, carotenoids and vitamins C and E and pancreatic cancer risk in The Netherlands Cohort Study.
Int J Cancer 2012; 130(1):147-58IJ

Abstract

Epidemiological data investigating the relation between fruit and vegetable consumption and pancreatic cancer risk have shown inconsistent results so far. Most case-control studies observed an inverse association with total fruit and vegetable consumption, whereas results from most cohort studies have largely been null. We examined prospectively the relation between pancreatic cancer risk and intake of vegetables, fruits, carotenoids and vitamins C and E. The Netherlands Cohort Study consisted of 120,852 men and women who completed a questionnaire at baseline in 1986, including a validated 150-item food-frequency questionnaire. After 16.3 years of follow-up, 423 cases were available for analysis. Total vegetable and total fruit consumption were not associated with pancreatic cancer risk (highest vs. lowest quintile, multivariable-adjusted hazard rate ratio = 1.23, 95% confidence interval: 0.86-1.75 and multivariable-adjusted hazard rate ratio = 0.90, 95% confidence interval: 0.66-1.24, respectively). Also, for cooked vegetables, raw vegetables and vegetables and fruits classified into subgroups, no associations were observed. Dietary carotenoids, vitamin C and E intake and supplements containing vitamin C or E were not associated with pancreatic cancer risk. The results were not modified by sex, smoking status and body mass index. In conclusion, we observed no association between a high consumption of vegetables and fruits and pancreatic cancer risk in this large cohort study, which is in agreement with previous prospective studies. Furthermore, we observed no association between the intake of carotenoids, vitamins and vitamin supplements and pancreatic cancer risk.

Authors+Show Affiliations

Department of Epidemiology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre+, Maastricht, The Netherlands. mirjam.heinen@maastrichtuniversity.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21328344

Citation

Heinen, Mirjam M., et al. "Intake of Vegetables, Fruits, Carotenoids and Vitamins C and E and Pancreatic Cancer Risk in the Netherlands Cohort Study." International Journal of Cancer, vol. 130, no. 1, 2012, pp. 147-58.
Heinen MM, Verhage BA, Goldbohm RA, et al. Intake of vegetables, fruits, carotenoids and vitamins C and E and pancreatic cancer risk in The Netherlands Cohort Study. Int J Cancer. 2012;130(1):147-58.
Heinen, M. M., Verhage, B. A., Goldbohm, R. A., & van den Brandt, P. A. (2012). Intake of vegetables, fruits, carotenoids and vitamins C and E and pancreatic cancer risk in The Netherlands Cohort Study. International Journal of Cancer, 130(1), pp. 147-58. doi:10.1002/ijc.25989.
Heinen MM, et al. Intake of Vegetables, Fruits, Carotenoids and Vitamins C and E and Pancreatic Cancer Risk in the Netherlands Cohort Study. Int J Cancer. 2012 Jan 1;130(1):147-58. PubMed PMID: 21328344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of vegetables, fruits, carotenoids and vitamins C and E and pancreatic cancer risk in The Netherlands Cohort Study. AU - Heinen,Mirjam M, AU - Verhage,Bas A J, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, Y1 - 2011/04/27/ PY - 2010/09/13/received PY - 2011/01/26/accepted PY - 2011/2/18/entrez PY - 2011/2/18/pubmed PY - 2011/12/21/medline SP - 147 EP - 58 JF - International journal of cancer JO - Int. J. Cancer VL - 130 IS - 1 N2 - Epidemiological data investigating the relation between fruit and vegetable consumption and pancreatic cancer risk have shown inconsistent results so far. Most case-control studies observed an inverse association with total fruit and vegetable consumption, whereas results from most cohort studies have largely been null. We examined prospectively the relation between pancreatic cancer risk and intake of vegetables, fruits, carotenoids and vitamins C and E. The Netherlands Cohort Study consisted of 120,852 men and women who completed a questionnaire at baseline in 1986, including a validated 150-item food-frequency questionnaire. After 16.3 years of follow-up, 423 cases were available for analysis. Total vegetable and total fruit consumption were not associated with pancreatic cancer risk (highest vs. lowest quintile, multivariable-adjusted hazard rate ratio = 1.23, 95% confidence interval: 0.86-1.75 and multivariable-adjusted hazard rate ratio = 0.90, 95% confidence interval: 0.66-1.24, respectively). Also, for cooked vegetables, raw vegetables and vegetables and fruits classified into subgroups, no associations were observed. Dietary carotenoids, vitamin C and E intake and supplements containing vitamin C or E were not associated with pancreatic cancer risk. The results were not modified by sex, smoking status and body mass index. In conclusion, we observed no association between a high consumption of vegetables and fruits and pancreatic cancer risk in this large cohort study, which is in agreement with previous prospective studies. Furthermore, we observed no association between the intake of carotenoids, vitamins and vitamin supplements and pancreatic cancer risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21328344/Intake_of_vegetables_fruits_carotenoids_and_vitamins_C_and_E_and_pancreatic_cancer_risk_in_The_Netherlands_Cohort_Study_ L2 - https://doi.org/10.1002/ijc.25989 DB - PRIME DP - Unbound Medicine ER -