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Prevalence and association of human parvovirus B19V with hepatitis B and C viruses in Nigeria.
J Med Virol. 2011 Apr; 83(4):710-6.JM

Abstract

Co-infection of parvovirus B19 with hepatitis B virus has been found in patients with acute and chronic hepatitis. The clinical significance of parvovirus B19 in hepatitis B co-infected patients is still controversial. In this study parvovirus B19 antibodies and DNA were investigated in serum samples from 76 patients with HBV infection, 17 with HBV/HCV co-infection and 44 healthy controls. In the sera from patients with HBV infection, anti-B19V IgM and IgG antibodies were detected in 24/76 (32%) and 25/76 (33%), in 6/17 (35%) and 8/17 (47%) of HBV/HCV co-infected patients, and in 14/44 (32%) and 12/44 (12%) of a non-hepatitis healthy controls, respectively. B19V DNA was detected in 8/76 (11%) of patients with HBV infection and in 3/17 (18%) of patients with a HBV/HCV co-infection, and in 4/44 (9%) healthy controls. The occurrence of parvovirus B19 DNA was significantly higher in patients with symptomatic HBV 4/20 (20%) compared to asymptomatic HBV carrier 4/56 (7%) (P<0.05). Ten of the positive B19V DNA sequences belonged to B19V genotype 1 while two belonged to genotype 3. The results of this study showed a significant difference in the prevalence of parvovirus B19 DNA in symptomatic HBsAg positive as compared to asymptomatic HBsAg positive individuals; however, the conclusion that parvovirus B19 infection increased the frequency of liver disease was not supported. Long-term longitudinal studies are, however, required to determine the synergistic effect of parvovirus B19 infection in HBV or HBV and HCV co-infected persons.

Authors+Show Affiliations

Institute for Tropical Medicine, University Tübingen, Tübingen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21328387

Citation

Opaleye, O O., et al. "Prevalence and Association of Human Parvovirus B19V With Hepatitis B and C Viruses in Nigeria." Journal of Medical Virology, vol. 83, no. 4, 2011, pp. 710-6.
Opaleye OO, Fagbami AH, Lalremruata A, et al. Prevalence and association of human parvovirus B19V with hepatitis B and C viruses in Nigeria. J Med Virol. 2011;83(4):710-6.
Opaleye, O. O., Fagbami, A. H., Lalremruata, A., & Kun, J. F. (2011). Prevalence and association of human parvovirus B19V with hepatitis B and C viruses in Nigeria. Journal of Medical Virology, 83(4), 710-6. https://doi.org/10.1002/jmv.22008
Opaleye OO, et al. Prevalence and Association of Human Parvovirus B19V With Hepatitis B and C Viruses in Nigeria. J Med Virol. 2011;83(4):710-6. PubMed PMID: 21328387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and association of human parvovirus B19V with hepatitis B and C viruses in Nigeria. AU - Opaleye,O O, AU - Fagbami,A H, AU - Lalremruata,A, AU - Kun,J F J, PY - 2011/2/18/entrez PY - 2011/2/18/pubmed PY - 2011/5/24/medline SP - 710 EP - 6 JF - Journal of medical virology JO - J Med Virol VL - 83 IS - 4 N2 - Co-infection of parvovirus B19 with hepatitis B virus has been found in patients with acute and chronic hepatitis. The clinical significance of parvovirus B19 in hepatitis B co-infected patients is still controversial. In this study parvovirus B19 antibodies and DNA were investigated in serum samples from 76 patients with HBV infection, 17 with HBV/HCV co-infection and 44 healthy controls. In the sera from patients with HBV infection, anti-B19V IgM and IgG antibodies were detected in 24/76 (32%) and 25/76 (33%), in 6/17 (35%) and 8/17 (47%) of HBV/HCV co-infected patients, and in 14/44 (32%) and 12/44 (12%) of a non-hepatitis healthy controls, respectively. B19V DNA was detected in 8/76 (11%) of patients with HBV infection and in 3/17 (18%) of patients with a HBV/HCV co-infection, and in 4/44 (9%) healthy controls. The occurrence of parvovirus B19 DNA was significantly higher in patients with symptomatic HBV 4/20 (20%) compared to asymptomatic HBV carrier 4/56 (7%) (P<0.05). Ten of the positive B19V DNA sequences belonged to B19V genotype 1 while two belonged to genotype 3. The results of this study showed a significant difference in the prevalence of parvovirus B19 DNA in symptomatic HBsAg positive as compared to asymptomatic HBsAg positive individuals; however, the conclusion that parvovirus B19 infection increased the frequency of liver disease was not supported. Long-term longitudinal studies are, however, required to determine the synergistic effect of parvovirus B19 infection in HBV or HBV and HCV co-infected persons. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/21328387/Prevalence_and_association_of_human_parvovirus_B19V_with_hepatitis_B_and_C_viruses_in_Nigeria_ L2 - https://doi.org/10.1002/jmv.22008 DB - PRIME DP - Unbound Medicine ER -