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Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation?
Turk J Gastroenterol. 2010 Dec; 21(4):360-4.TJ

Abstract

BACKGROUND/AIMS

In the present study, we aimed to investigate if partially hydrolyzed guar gum (PHGG) can be used safely as a fiber source for treatment of constipation in children and to compare its success with the most commonly used osmotic laxative, lactulose.

METHODS

A randomized prospective controlled study on 61 patients (partially hydrolyzed guar gum group, n: 31; lactulose group, n: 30) was performed. Patients were given lactulose or partially hydrolyzed guar gum for four weeks. Using a standardized bowel diary, defecation frequency, stool consistency, and presence of flatulence and abdominal pain were recorded. Family questionnaires about the success, safety and side effect profile of both treatment arms were also obtained.

RESULTS

No significant differences were found in the baseline daily fiber (fruits and vegetables) intake between the two groups. Bowel movement frequency per week and stool consistency improved significantly in both treatment groups (p<0.05). The percent of children with abdominal pain and stool withholding also decreased eminently in both groups (p<0.05). Weekly defecation frequency increased from 4±0.7 to 6±1.06 and from 4±0.7 to 5±1.7 in the lactulose and partially hydrolyzed guar gum treated groups, respectively (p<0.05). According to the family questionnaire, the parents complained of bad taste, flatulence and necessity to ingest a high amount of drug in the lactulose treatment group. In the partially hydrolyzed guar gum treatment group, parents were satisfied with the defecation frequency of their children.

CONCLUSIONS

Treatment with partially hydrolyzed guar gum is as effective as lactulose treatment in relieving stool withholding and constipation-associated abdominal pain, and its use improves stool consistency. Lactulose seemed to have more side effects, including flatulence and sensation of bad taste.

Authors+Show Affiliations

Department of Pediatric Gastroenterology, Zonguldak Karaelmas University, School of Medicine, Zonguldak. gonnazyuc@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21331988

Citation

Üstündağ, Gonca, et al. "Can Partially Hydrolyzed Guar Gum Be an Alternative to Lactulose in Treatment of Childhood Constipation?" The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, vol. 21, no. 4, 2010, pp. 360-4.
Üstündağ G, Kuloğlu Z, Kirbaş N, et al. Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation? Turk J Gastroenterol. 2010;21(4):360-4.
Üstündağ, G., Kuloğlu, Z., Kirbaş, N., & Kansu, A. (2010). Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation? The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, 21(4), 360-4.
Üstündağ G, et al. Can Partially Hydrolyzed Guar Gum Be an Alternative to Lactulose in Treatment of Childhood Constipation. Turk J Gastroenterol. 2010;21(4):360-4. PubMed PMID: 21331988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation? AU - Üstündağ,Gonca, AU - Kuloğlu,Zarife, AU - Kirbaş,Nihan, AU - Kansu,Aydan, PY - 2011/2/19/entrez PY - 2011/2/19/pubmed PY - 2011/6/15/medline SP - 360 EP - 4 JF - The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology JO - Turk J Gastroenterol VL - 21 IS - 4 N2 - BACKGROUND/AIMS: In the present study, we aimed to investigate if partially hydrolyzed guar gum (PHGG) can be used safely as a fiber source for treatment of constipation in children and to compare its success with the most commonly used osmotic laxative, lactulose. METHODS: A randomized prospective controlled study on 61 patients (partially hydrolyzed guar gum group, n: 31; lactulose group, n: 30) was performed. Patients were given lactulose or partially hydrolyzed guar gum for four weeks. Using a standardized bowel diary, defecation frequency, stool consistency, and presence of flatulence and abdominal pain were recorded. Family questionnaires about the success, safety and side effect profile of both treatment arms were also obtained. RESULTS: No significant differences were found in the baseline daily fiber (fruits and vegetables) intake between the two groups. Bowel movement frequency per week and stool consistency improved significantly in both treatment groups (p<0.05). The percent of children with abdominal pain and stool withholding also decreased eminently in both groups (p<0.05). Weekly defecation frequency increased from 4±0.7 to 6±1.06 and from 4±0.7 to 5±1.7 in the lactulose and partially hydrolyzed guar gum treated groups, respectively (p<0.05). According to the family questionnaire, the parents complained of bad taste, flatulence and necessity to ingest a high amount of drug in the lactulose treatment group. In the partially hydrolyzed guar gum treatment group, parents were satisfied with the defecation frequency of their children. CONCLUSIONS: Treatment with partially hydrolyzed guar gum is as effective as lactulose treatment in relieving stool withholding and constipation-associated abdominal pain, and its use improves stool consistency. Lactulose seemed to have more side effects, including flatulence and sensation of bad taste. SN - 2148-5607 UR - https://www.unboundmedicine.com/medline/citation/21331988/Can_partially_hydrolyzed_guar_gum_be_an_alternative_to_lactulose_in_treatment_of_childhood_constipation L2 - http://www.turkjgastroenterol.org/eng/makale/3242/220/Full-Text DB - PRIME DP - Unbound Medicine ER -