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Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation.

Abstract

We have previously reported a protective effect of maternal omega-3 long-chain polyunsaturated fatty acids (ω-3 LCPUFA) supplementation in pregnancy and lactation on IgE-associated eczema and food allergy in the infant during the first year of life. Here we investigate whether the effects of the LCPUFA supplementation on IgE-associated diseases last up to 2 yr of age and assess the relationship between plasma proportions of ω-3 PUFAs and the frequency and severity of infant allergic disease. 145 pregnant women, at risk of having an allergic infant, were randomized to daily supplementation with 1.6 g eicosapentaenoic acid (EPA) and 1.1 g docosahexaenoic acid (DHA) or placebo starting in the 25th gestational week and continuing through 3.5 months of breastfeeding. Clinical examinations, skin prick tests and analysis of maternal and infant plasma phospholipid fatty acids and infant specific IgE were performed. No difference in the prevalence of allergic symptoms was found between the intervention groups. The cumulative incidence of IgE-associated disease was lower in the ω-3-supplemented group (6/54, 13%) compared with the placebo group (19/62, 30%, p=0.01). Higher maternal and infant proportions of DHA and EPA were associated with lower prevalence of IgE associated disease (p=0.01-0.05) in a dose-dependent manner. Higher maternal and infant proportions of DHA and EPA were found if the infants presented none, when compared with multiple allergic symptoms, (p<0.05) regardless of sensitization. In summary, the ω-3 supplementation offered no obvious preventive effect on the prevalence of clinical symptoms of allergic disease, but the decrease in cumulative incidence of IgE-associated disease seen during the first year still remained until 2 yr of age. Furthermore, high proportions of DHA and EPA in maternal and infant plasma phospholipids were associated with less IgE-associated disease and a reduced severity of the allergic phenotype.

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  • Authors+Show Affiliations

    ,

    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. catrin.furuhjelm@telia.com

    , , , , ,

    Source

    MeSH

    Adult
    Blood
    Dermatitis, Atopic
    Dietary Supplements
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Fatty Acids, Omega-3
    Female
    Fish Oils
    Food Hypersensitivity
    Humans
    Immunity, Maternally-Acquired
    Immunoglobulin E
    Infant
    Infant, Newborn
    Lactation
    Maternal Nutritional Physiological Phenomena
    Pregnancy
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21332799

    Citation

    Furuhjelm, Catrin, et al. "Allergic Disease in Infants Up to 2 Years of Age in Relation to Plasma Omega-3 Fatty Acids and Maternal Fish Oil Supplementation in Pregnancy and Lactation." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 22, no. 5, 2011, pp. 505-14.
    Furuhjelm C, Warstedt K, Fagerås M, et al. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatr Allergy Immunol. 2011;22(5):505-14.
    Furuhjelm, C., Warstedt, K., Fagerås, M., Fälth-Magnusson, K., Larsson, J., Fredriksson, M., & Duchén, K. (2011). Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 22(5), pp. 505-14. doi:10.1111/j.1399-3038.2010.01096.x.
    Furuhjelm C, et al. Allergic Disease in Infants Up to 2 Years of Age in Relation to Plasma Omega-3 Fatty Acids and Maternal Fish Oil Supplementation in Pregnancy and Lactation. Pediatr Allergy Immunol. 2011;22(5):505-14. PubMed PMID: 21332799.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. AU - Furuhjelm,Catrin, AU - Warstedt,Kristina, AU - Fagerås,Malin, AU - Fälth-Magnusson,Karin, AU - Larsson,Johanna, AU - Fredriksson,Mats, AU - Duchén,Karel, Y1 - 2011/02/20/ PY - 2011/2/22/entrez PY - 2011/2/22/pubmed PY - 2011/12/13/medline SP - 505 EP - 14 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 22 IS - 5 N2 - We have previously reported a protective effect of maternal omega-3 long-chain polyunsaturated fatty acids (ω-3 LCPUFA) supplementation in pregnancy and lactation on IgE-associated eczema and food allergy in the infant during the first year of life. Here we investigate whether the effects of the LCPUFA supplementation on IgE-associated diseases last up to 2 yr of age and assess the relationship between plasma proportions of ω-3 PUFAs and the frequency and severity of infant allergic disease. 145 pregnant women, at risk of having an allergic infant, were randomized to daily supplementation with 1.6 g eicosapentaenoic acid (EPA) and 1.1 g docosahexaenoic acid (DHA) or placebo starting in the 25th gestational week and continuing through 3.5 months of breastfeeding. Clinical examinations, skin prick tests and analysis of maternal and infant plasma phospholipid fatty acids and infant specific IgE were performed. No difference in the prevalence of allergic symptoms was found between the intervention groups. The cumulative incidence of IgE-associated disease was lower in the ω-3-supplemented group (6/54, 13%) compared with the placebo group (19/62, 30%, p=0.01). Higher maternal and infant proportions of DHA and EPA were associated with lower prevalence of IgE associated disease (p=0.01-0.05) in a dose-dependent manner. Higher maternal and infant proportions of DHA and EPA were found if the infants presented none, when compared with multiple allergic symptoms, (p<0.05) regardless of sensitization. In summary, the ω-3 supplementation offered no obvious preventive effect on the prevalence of clinical symptoms of allergic disease, but the decrease in cumulative incidence of IgE-associated disease seen during the first year still remained until 2 yr of age. Furthermore, high proportions of DHA and EPA in maternal and infant plasma phospholipids were associated with less IgE-associated disease and a reduced severity of the allergic phenotype. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/21332799/Allergic_disease_in_infants_up_to_2_years_of_age_in_relation_to_plasma_omega_3_fatty_acids_and_maternal_fish_oil_supplementation_in_pregnancy_and_lactation_ L2 - https://doi.org/10.1111/j.1399-3038.2010.01096.x DB - PRIME DP - Unbound Medicine ER -