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Benchmark dose approach for low-level lead induced haematogenesis inhibition and associations of childhood intelligences with ALAD activity and ALA levels.
Sci Total Environ. 2011 Apr 15; 409(10):1806-10.ST

Abstract

Lead (Pb) levels, delta-aminolevulinic acid dehydratase (ALAD) activities, zinc protoporphyrin (ZPP) levels in blood, and urinary delta-aminolevulinic acid (ALA) and coproporphyrin (CP) concentrations were measured for 318 environmental Pb exposed children recruited from an area of southeast China. The mean of blood lead (PbB) levels was 75.0μg/L among all subjects. Benchmark dose (BMD) method was conducted to present a lower PbB BMD (lower bound of BMD) of 32.4μg/L (22.7) based on ALAD activity than those based on the other three haematological indices, corresponding to a benchmark response of 1%. Childhood intelligence degrees were not associated significantly with ALAD activities or ALA levels. It was concluded that blood ALAD activity is a sensitive indicator of early haematological damage due to low-level Pb exposures for children.

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Authors+Show Affiliations

Wang Q
Department of Epidemiology & Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China. lwq95@126.com
Ye LX
No affiliation info available
Zhao HH
No affiliation info available
Chen JW
No affiliation info available
Zhou YK
No affiliation info available

MeSH

Aminolevulinic AcidBenchmarkingBiomarkersChildCoproporphyrinsDose-Response Relationship, DrugEnvironmental PollutantsFemaleHematopoiesisHumansIntelligenceLeadMalePorphobilinogen SynthaseProtoporphyrins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21334730

Citation

Wang, Q, et al. "Benchmark Dose Approach for Low-level Lead Induced Haematogenesis Inhibition and Associations of Childhood Intelligences With ALAD Activity and ALA Levels." The Science of the Total Environment, vol. 409, no. 10, 2011, pp. 1806-10.
Wang Q, Ye LX, Zhao HH, et al. Benchmark dose approach for low-level lead induced haematogenesis inhibition and associations of childhood intelligences with ALAD activity and ALA levels. Sci Total Environ. 2011;409(10):1806-10.
Wang, Q., Ye, L. X., Zhao, H. H., Chen, J. W., & Zhou, Y. K. (2011). Benchmark dose approach for low-level lead induced haematogenesis inhibition and associations of childhood intelligences with ALAD activity and ALA levels. The Science of the Total Environment, 409(10), 1806-10. https://doi.org/10.1016/j.scitotenv.2011.01.045
Wang Q, et al. Benchmark Dose Approach for Low-level Lead Induced Haematogenesis Inhibition and Associations of Childhood Intelligences With ALAD Activity and ALA Levels. Sci Total Environ. 2011 Apr 15;409(10):1806-10. PubMed PMID: 21334730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benchmark dose approach for low-level lead induced haematogenesis inhibition and associations of childhood intelligences with ALAD activity and ALA levels. AU - Wang,Q, AU - Ye,L X, AU - Zhao,H H, AU - Chen,J W, AU - Zhou,Y K, Y1 - 2011/02/21/ PY - 2010/08/22/received PY - 2011/01/26/revised PY - 2011/01/26/accepted PY - 2011/2/22/entrez PY - 2011/2/22/pubmed PY - 2011/5/26/medline SP - 1806 EP - 10 JF - The Science of the total environment JO - Sci Total Environ VL - 409 IS - 10 N2 - Lead (Pb) levels, delta-aminolevulinic acid dehydratase (ALAD) activities, zinc protoporphyrin (ZPP) levels in blood, and urinary delta-aminolevulinic acid (ALA) and coproporphyrin (CP) concentrations were measured for 318 environmental Pb exposed children recruited from an area of southeast China. The mean of blood lead (PbB) levels was 75.0μg/L among all subjects. Benchmark dose (BMD) method was conducted to present a lower PbB BMD (lower bound of BMD) of 32.4μg/L (22.7) based on ALAD activity than those based on the other three haematological indices, corresponding to a benchmark response of 1%. Childhood intelligence degrees were not associated significantly with ALAD activities or ALA levels. It was concluded that blood ALAD activity is a sensitive indicator of early haematological damage due to low-level Pb exposures for children. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/21334730/Benchmark_dose_approach_for_low_level_lead_induced_haematogenesis_inhibition_and_associations_of_childhood_intelligences_with_ALAD_activity_and_ALA_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(11)00104-5 DB - PRIME DP - Unbound Medicine ER -