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A cross-sectional study of vitamin D and insulin resistance in children.
Arch Dis Child. 2011 May; 96(5):447-52.AD

Abstract

OBJECTIVE

Vitamin D deficiency is common and has been associated with several non-bone/calcium related outcomes. The objective was to determine the association between serum 25-hydroxyvitamin D (25-OH-D) and fasting glucose, insulin and insulin sensitivity in obese and non-obese children. PATIENTS/SETTING/DESIGN: Cross-sectional study of 85 children aged 4-18 years recruited from the local Philadelphia community and Sleep Center.

MAIN OUTCOME MEASURES

Fasting blood glucose, insulin and 25-OH-D were measured. Insulin resistance was calculated using homeostasis model assessment (HOMA). Body mass index standard deviation scores (BMI-Z) and pubertal stage were determined. Multivariable linear regression was used to determine factors associated with decreased 25-OH-D and to determine the association of vitamin D with HOMA.

RESULTS

Median 25-OH-D was 52 nmol/l (IQR 34-76). 26% of subjects were vitamin D sufficient (25-OH-D ≥75 nmol/l), 27% had intermediate values (50-75 nmol/l) and 47% were insufficient (25-50 nmol/l) or frankly deficient (<25 nmol/l). In the multivariable model, older age, higher BMI-Z and African-American race were all negatively associated with 25-OH-D; summer was positively associated with 25-OH-D. Lower 25-OH-D was associated with higher fasting blood glucose, insulin and HOMA after adjustment for puberty and BMI-Z.

CONCLUSION

Low 25-OH-D, common in the paediatric population at risk for diabetes (older children, African-Americans, children with increasing BMI-Z) is associated with worse insulin resistance.

Authors+Show Affiliations

Division of Endocrinology/Diabetes, 1130 Northwest Tower, The Children's Hospital of Philadelphia, 34th & Civic Center Boulevard, Philadelphia, PA 19104, USA. kellya@email.chop.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21335626

Citation

Kelly, Andrea, et al. "A Cross-sectional Study of Vitamin D and Insulin Resistance in Children." Archives of Disease in Childhood, vol. 96, no. 5, 2011, pp. 447-52.
Kelly A, Brooks LJ, Dougherty S, et al. A cross-sectional study of vitamin D and insulin resistance in children. Arch Dis Child. 2011;96(5):447-52.
Kelly, A., Brooks, L. J., Dougherty, S., Carlow, D. C., & Zemel, B. S. (2011). A cross-sectional study of vitamin D and insulin resistance in children. Archives of Disease in Childhood, 96(5), 447-52. https://doi.org/10.1136/adc.2010.187591
Kelly A, et al. A Cross-sectional Study of Vitamin D and Insulin Resistance in Children. Arch Dis Child. 2011;96(5):447-52. PubMed PMID: 21335626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cross-sectional study of vitamin D and insulin resistance in children. AU - Kelly,Andrea, AU - Brooks,Lee J, AU - Dougherty,Shayne, AU - Carlow,Dean C, AU - Zemel,Babette S, Y1 - 2011/02/20/ PY - 2011/2/22/entrez PY - 2011/2/22/pubmed PY - 2011/6/15/medline SP - 447 EP - 52 JF - Archives of disease in childhood JO - Arch. Dis. Child. VL - 96 IS - 5 N2 - OBJECTIVE: Vitamin D deficiency is common and has been associated with several non-bone/calcium related outcomes. The objective was to determine the association between serum 25-hydroxyvitamin D (25-OH-D) and fasting glucose, insulin and insulin sensitivity in obese and non-obese children. PATIENTS/SETTING/DESIGN: Cross-sectional study of 85 children aged 4-18 years recruited from the local Philadelphia community and Sleep Center. MAIN OUTCOME MEASURES: Fasting blood glucose, insulin and 25-OH-D were measured. Insulin resistance was calculated using homeostasis model assessment (HOMA). Body mass index standard deviation scores (BMI-Z) and pubertal stage were determined. Multivariable linear regression was used to determine factors associated with decreased 25-OH-D and to determine the association of vitamin D with HOMA. RESULTS: Median 25-OH-D was 52 nmol/l (IQR 34-76). 26% of subjects were vitamin D sufficient (25-OH-D ≥75 nmol/l), 27% had intermediate values (50-75 nmol/l) and 47% were insufficient (25-50 nmol/l) or frankly deficient (<25 nmol/l). In the multivariable model, older age, higher BMI-Z and African-American race were all negatively associated with 25-OH-D; summer was positively associated with 25-OH-D. Lower 25-OH-D was associated with higher fasting blood glucose, insulin and HOMA after adjustment for puberty and BMI-Z. CONCLUSION: Low 25-OH-D, common in the paediatric population at risk for diabetes (older children, African-Americans, children with increasing BMI-Z) is associated with worse insulin resistance. SN - 1468-2044 UR - https://www.unboundmedicine.com/medline/citation/21335626/A_cross_sectional_study_of_vitamin_D_and_insulin_resistance_in_children_ L2 - http://adc.bmj.com/cgi/pmidlookup?view=long&amp;pmid=21335626 DB - PRIME DP - Unbound Medicine ER -