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Is liver transaminases assessment an appropriate tool for the screening of non-alcoholic fatty liver disease in at risk obese children and adolescents?
Nutr Hosp. 2010 Sep-Oct; 25(5):712-7.NH

Abstract

Pediatric obesity has increased dramatically all over the world and nonalcoholic fatty liver disease (NAFLD) is one of the most frequent complications associated with excess adiposity. NAFLD causes serum transaminase elevation and liver disease, which could end up in fibrosis, cirrhosis and eventually hepatocellular carcinoma. NAFLD seems to be associated with the metabolic complications of obesity, mainly insulin resistance. The aim of the present article is to review the role of serum liver enzyme assessment as a suitable non invasive predictor of NAFLD in children. Although serum liver enzyme elevation does not accurately measure liver damage, it may be a valuable and non invasive test to screen NAFLD in children and adolescents and a marker to control NAFLD evolution. To detect NAFLD in obese children and adolescents, transaminases serum concentrations should be routinely determined in these patients. In this sense, it seems necessary to obtain transaminase reference standards for children and adolescents.

Authors+Show Affiliations

Growth, Exercise, Nutrition and Development Research Group, Departamento de Pediatría, Radiología y Medicina Física, University of Zaragoza, and Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain. gereva@comz.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21336425

Citation

Rodríguez, G, et al. "Is Liver Transaminases Assessment an Appropriate Tool for the Screening of Non-alcoholic Fatty Liver Disease in at Risk Obese Children and Adolescents?" Nutricion Hospitalaria, vol. 25, no. 5, 2010, pp. 712-7.
Rodríguez G, Gallego S, Breidenassel C, et al. Is liver transaminases assessment an appropriate tool for the screening of non-alcoholic fatty liver disease in at risk obese children and adolescents? Nutr Hosp. 2010;25(5):712-7.
Rodríguez, G., Gallego, S., Breidenassel, C., Moreno, L. A., & Gottrand, F. (2010). Is liver transaminases assessment an appropriate tool for the screening of non-alcoholic fatty liver disease in at risk obese children and adolescents? Nutricion Hospitalaria, 25(5), 712-7.
Rodríguez G, et al. Is Liver Transaminases Assessment an Appropriate Tool for the Screening of Non-alcoholic Fatty Liver Disease in at Risk Obese Children and Adolescents. Nutr Hosp. 2010 Sep-Oct;25(5):712-7. PubMed PMID: 21336425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is liver transaminases assessment an appropriate tool for the screening of non-alcoholic fatty liver disease in at risk obese children and adolescents? AU - Rodríguez,G, AU - Gallego,S, AU - Breidenassel,C, AU - Moreno,L A, AU - Gottrand,F, PY - 2010/02/23/received PY - 2010/04/17/accepted PY - 2011/2/22/entrez PY - 2011/2/22/pubmed PY - 2011/6/16/medline SP - 712 EP - 7 JF - Nutricion hospitalaria JO - Nutr Hosp VL - 25 IS - 5 N2 - Pediatric obesity has increased dramatically all over the world and nonalcoholic fatty liver disease (NAFLD) is one of the most frequent complications associated with excess adiposity. NAFLD causes serum transaminase elevation and liver disease, which could end up in fibrosis, cirrhosis and eventually hepatocellular carcinoma. NAFLD seems to be associated with the metabolic complications of obesity, mainly insulin resistance. The aim of the present article is to review the role of serum liver enzyme assessment as a suitable non invasive predictor of NAFLD in children. Although serum liver enzyme elevation does not accurately measure liver damage, it may be a valuable and non invasive test to screen NAFLD in children and adolescents and a marker to control NAFLD evolution. To detect NAFLD in obese children and adolescents, transaminases serum concentrations should be routinely determined in these patients. In this sense, it seems necessary to obtain transaminase reference standards for children and adolescents. SN - 1699-5198 UR - https://www.unboundmedicine.com/medline/citation/21336425/Is_liver_transaminases_assessment_an_appropriate_tool_for_the_screening_of_non_alcoholic_fatty_liver_disease_in_at_risk_obese_children_and_adolescents L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -