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Scalp stratum corneum histamine levels: novel sampling method reveals association with itch resolution in dandruff/seborrhoeic dermatitis treatment.
Acta Derm Venereol. 2011 Jun; 91(4):404-8.AD

Abstract

Dandruff and seborrhoeic dermatitis are accompanied by bothersome itch. We have established a novel non-invasive methodology to sample histamine levels in the stratum corneum in order to facilitate an understanding of pruritogenesis in this condition. Histamine levels were assessed in two groups of subjects with dandruff before and after 3 weeks of treatment with a commercial potentiated zinc pyrithione shampoo. A comparative population without dandruff was also studied. Itch self-perception was quantified on a visual analogue scale. The histamine level in subjects with dandruff was more than twice that in those who did not have dandruff. Under conditions known to resolve flaking symptoms, the shampoo led to a reduction in histamine in subjects with dandruff to a level that was statistically indistinguishable from those who did not have dandruff. This reduction in histamine was accompanied by a highly significant reduction in the perception of itch intensity. These findings suggest an association between the subjective perception of itch in the scalp and the level of histamine in the skin.

Authors+Show Affiliations

The Procter and Gamble Company, Cincinnati, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21336476

Citation

Kerr, Kathy, et al. "Scalp Stratum Corneum Histamine Levels: Novel Sampling Method Reveals Association With Itch Resolution in Dandruff/seborrhoeic Dermatitis Treatment." Acta Dermato-venereologica, vol. 91, no. 4, 2011, pp. 404-8.
Kerr K, Schwartz JR, Filloon T, et al. Scalp stratum corneum histamine levels: novel sampling method reveals association with itch resolution in dandruff/seborrhoeic dermatitis treatment. Acta Derm Venereol. 2011;91(4):404-8.
Kerr, K., Schwartz, J. R., Filloon, T., Fieno, A., Wehmeyer, K., Szepietowski, J. C., & Mills, K. J. (2011). Scalp stratum corneum histamine levels: novel sampling method reveals association with itch resolution in dandruff/seborrhoeic dermatitis treatment. Acta Dermato-venereologica, 91(4), 404-8. https://doi.org/10.2340/00015555-1073
Kerr K, et al. Scalp Stratum Corneum Histamine Levels: Novel Sampling Method Reveals Association With Itch Resolution in Dandruff/seborrhoeic Dermatitis Treatment. Acta Derm Venereol. 2011;91(4):404-8. PubMed PMID: 21336476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scalp stratum corneum histamine levels: novel sampling method reveals association with itch resolution in dandruff/seborrhoeic dermatitis treatment. AU - Kerr,Kathy, AU - Schwartz,James R, AU - Filloon,Thomas, AU - Fieno,Angela, AU - Wehmeyer,Ken, AU - Szepietowski,Jacek C, AU - Mills,Kevin J, PY - 2011/2/22/entrez PY - 2011/2/22/pubmed PY - 2011/10/15/medline SP - 404 EP - 8 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 91 IS - 4 N2 - Dandruff and seborrhoeic dermatitis are accompanied by bothersome itch. We have established a novel non-invasive methodology to sample histamine levels in the stratum corneum in order to facilitate an understanding of pruritogenesis in this condition. Histamine levels were assessed in two groups of subjects with dandruff before and after 3 weeks of treatment with a commercial potentiated zinc pyrithione shampoo. A comparative population without dandruff was also studied. Itch self-perception was quantified on a visual analogue scale. The histamine level in subjects with dandruff was more than twice that in those who did not have dandruff. Under conditions known to resolve flaking symptoms, the shampoo led to a reduction in histamine in subjects with dandruff to a level that was statistically indistinguishable from those who did not have dandruff. This reduction in histamine was accompanied by a highly significant reduction in the perception of itch intensity. These findings suggest an association between the subjective perception of itch in the scalp and the level of histamine in the skin. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/21336476/Scalp_stratum_corneum_histamine_levels:_novel_sampling_method_reveals_association_with_itch_resolution_in_dandruff/seborrhoeic_dermatitis_treatment_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-1073 DB - PRIME DP - Unbound Medicine ER -