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Radiotherapy of solitary plasmacytoma.
Ann Hematol. 2011 Sep; 90(9):1093-7.AH

Abstract

Solitary plasmacytoma of the bone (SBP) or extramedullary plasmacytoma (EP) are rare neoplasms amenable to local radiotherapy. In this retrospective analysis, we report the University Heidelberg experience in the treatment of solitary plasmacytoma. From 1995 to 2008, 18 patients were treated with local radiotherapy. Ten patients suffered from SBP, eight patients showed a single extramedullary lesion. Local radiotherapy with a median dose of 45 Gy yielded excellent local control with only one patient suffering from local relapse. SBP and EP had significantly different 5-year multiple myeloma-free survival rates of 36.8% and 86.7%, respectively. However, no significant difference in overall survival could be detected. Radiotherapy can achieve excellent local control of solitary plasmacytoma. Progression to multiple myeloma, especially in the case of SBP, remains to be addressed by further studies.

Authors+Show Affiliations

Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. sonja.krause@med.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

21336625

Citation

Krause, Sonja, et al. "Radiotherapy of Solitary Plasmacytoma." Annals of Hematology, vol. 90, no. 9, 2011, pp. 1093-7.
Krause S, Hillengass J, Goldschmidt H, et al. Radiotherapy of solitary plasmacytoma. Ann Hematol. 2011;90(9):1093-7.
Krause, S., Hillengass, J., Goldschmidt, H., Debus, J., & Neuhof, D. (2011). Radiotherapy of solitary plasmacytoma. Annals of Hematology, 90(9), 1093-7. https://doi.org/10.1007/s00277-011-1190-7
Krause S, et al. Radiotherapy of Solitary Plasmacytoma. Ann Hematol. 2011;90(9):1093-7. PubMed PMID: 21336625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radiotherapy of solitary plasmacytoma. AU - Krause,Sonja, AU - Hillengass,Jens, AU - Goldschmidt,Hartmut, AU - Debus,Jürgen, AU - Neuhof,Dirk, Y1 - 2011/02/19/ PY - 2010/11/18/received PY - 2011/02/07/accepted PY - 2011/2/22/entrez PY - 2011/2/22/pubmed PY - 2011/10/1/medline SP - 1093 EP - 7 JF - Annals of hematology JO - Ann Hematol VL - 90 IS - 9 N2 - Solitary plasmacytoma of the bone (SBP) or extramedullary plasmacytoma (EP) are rare neoplasms amenable to local radiotherapy. In this retrospective analysis, we report the University Heidelberg experience in the treatment of solitary plasmacytoma. From 1995 to 2008, 18 patients were treated with local radiotherapy. Ten patients suffered from SBP, eight patients showed a single extramedullary lesion. Local radiotherapy with a median dose of 45 Gy yielded excellent local control with only one patient suffering from local relapse. SBP and EP had significantly different 5-year multiple myeloma-free survival rates of 36.8% and 86.7%, respectively. However, no significant difference in overall survival could be detected. Radiotherapy can achieve excellent local control of solitary plasmacytoma. Progression to multiple myeloma, especially in the case of SBP, remains to be addressed by further studies. SN - 1432-0584 UR - https://www.unboundmedicine.com/medline/citation/21336625/Radiotherapy_of_solitary_plasmacytoma_ L2 - https://dx.doi.org/10.1007/s00277-011-1190-7 DB - PRIME DP - Unbound Medicine ER -