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Controlled HIV viral replication, not liver disease severity associated with low bone mineral density in HIV/HCV co-infection.
J Hepatol. 2011 Oct; 55(4):770-6.JH

Abstract

BACKGROUND & AIMS

To evaluate the prevalence and risk factors for low bone mineral density (BMD) in persons co-infected with HIV and Hepatitis C.

METHODS

HIV/HCV co-infected study participants (n=179) were recruited into a prospective cohort and underwent dual-energy X-ray absorptiometry (DXA) within 1 year of a liver biopsy. Fibrosis staging was evaluated according to the METAVIR system. Osteoporosis was defined as a T-score ≤-2.5. Z-scores at the total hip, femoral neck, and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease, HIV-related variables, and BMD.

RESULTS

The population was 65% male, 85% Black with mean age 50.3 years. The prevalence of osteoporosis either at the total hip, femoral neck, or lumbar spine was 28%, with 5% having osteoporosis of the total hip, 6% at the femoral neck, 25% at the spine. The mean Z-scores (standard deviation) were -0.42 (1.01) at the total hip, -0.16 (1.05) at the femoral neck, and -0.82 (1.55) at the lumbar spine. In multivariable models, controlled HIV replication (HIV RNA <400 copies/ml vs. ≥400 copies/ml) was associated with lower Z-scores (mean ± standard error) at the total hip (-0.44 ± 0.17, p = 0.01), femoral neck (-0.59 ± 0.18, p = 0.001), and the spine (-0.98 ± 0.27, p = 0.0005). There was no association between degree of liver fibrosis and Z-score.

CONCLUSIONS

Osteoporosis was very common in this population of predominately African-American HIV/HCV co-infected patients, particularly at the spine. Lower BMD was associated with controlled HIV replication, but not liver disease severity.

Authors+Show Affiliations

Johns Hopkins School of Medicine, Baltimore, MD, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21338640

Citation

El-Maouche, Diala, et al. "Controlled HIV Viral Replication, Not Liver Disease Severity Associated With Low Bone Mineral Density in HIV/HCV Co-infection." Journal of Hepatology, vol. 55, no. 4, 2011, pp. 770-6.
El-Maouche D, Mehta SH, Sutcliffe C, et al. Controlled HIV viral replication, not liver disease severity associated with low bone mineral density in HIV/HCV co-infection. J Hepatol. 2011;55(4):770-6.
El-Maouche, D., Mehta, S. H., Sutcliffe, C., Higgins, Y., Torbenson, M. S., Moore, R. D., Thomas, D. L., Sulkowski, M. S., & Brown, T. T. (2011). Controlled HIV viral replication, not liver disease severity associated with low bone mineral density in HIV/HCV co-infection. Journal of Hepatology, 55(4), 770-6. https://doi.org/10.1016/j.jhep.2011.01.035
El-Maouche D, et al. Controlled HIV Viral Replication, Not Liver Disease Severity Associated With Low Bone Mineral Density in HIV/HCV Co-infection. J Hepatol. 2011;55(4):770-6. PubMed PMID: 21338640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled HIV viral replication, not liver disease severity associated with low bone mineral density in HIV/HCV co-infection. AU - El-Maouche,Diala, AU - Mehta,Shruti H, AU - Sutcliffe,Catherine, AU - Higgins,Yvonne, AU - Torbenson,Michael S, AU - Moore,Richard D, AU - Thomas,David L, AU - Sulkowski,Mark S, AU - Brown,Todd T, Y1 - 2011/02/19/ PY - 2010/10/07/received PY - 2011/01/21/revised PY - 2011/01/27/accepted PY - 2011/2/23/entrez PY - 2011/2/23/pubmed PY - 2011/12/13/medline SP - 770 EP - 6 JF - Journal of hepatology JO - J. Hepatol. VL - 55 IS - 4 N2 - BACKGROUND & AIMS: To evaluate the prevalence and risk factors for low bone mineral density (BMD) in persons co-infected with HIV and Hepatitis C. METHODS: HIV/HCV co-infected study participants (n=179) were recruited into a prospective cohort and underwent dual-energy X-ray absorptiometry (DXA) within 1 year of a liver biopsy. Fibrosis staging was evaluated according to the METAVIR system. Osteoporosis was defined as a T-score ≤-2.5. Z-scores at the total hip, femoral neck, and lumbar spine were used as the primary outcome variables to assess the association between degree of liver disease, HIV-related variables, and BMD. RESULTS: The population was 65% male, 85% Black with mean age 50.3 years. The prevalence of osteoporosis either at the total hip, femoral neck, or lumbar spine was 28%, with 5% having osteoporosis of the total hip, 6% at the femoral neck, 25% at the spine. The mean Z-scores (standard deviation) were -0.42 (1.01) at the total hip, -0.16 (1.05) at the femoral neck, and -0.82 (1.55) at the lumbar spine. In multivariable models, controlled HIV replication (HIV RNA <400 copies/ml vs. ≥400 copies/ml) was associated with lower Z-scores (mean ± standard error) at the total hip (-0.44 ± 0.17, p = 0.01), femoral neck (-0.59 ± 0.18, p = 0.001), and the spine (-0.98 ± 0.27, p = 0.0005). There was no association between degree of liver fibrosis and Z-score. CONCLUSIONS: Osteoporosis was very common in this population of predominately African-American HIV/HCV co-infected patients, particularly at the spine. Lower BMD was associated with controlled HIV replication, but not liver disease severity. SN - 1600-0641 UR - https://www.unboundmedicine.com/medline/citation/21338640/Controlled_HIV_viral_replication_not_liver_disease_severity_associated_with_low_bone_mineral_density_in_HIV/HCV_co_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(11)00166-8 DB - PRIME DP - Unbound Medicine ER -