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Pregnancy outcome after in utero exposure to angiotensin converting enzyme inhibitors or angiotensin receptor blockers.
Reprod Toxicol 2011; 31(4):540-5RT

Abstract

OBJECTIVE

To examine first trimester safety of angiotensin-converting-enzyme-inhibitors (ACEIs) or angiotensin-receptor-blockers (ARBs).

STUDY DESIGN

Prospective observational cohort regarding pregnancy ACEI/ARBs-exposure including contacts to two Teratology Information Services in Israel (1994-2007) and Italy (1990-2008), with two comparison groups: (1) exposed to other antihypertensives (OAH) (2) after non-teratogenic exposure (NTE) in similar time frames.

RESULTS

252 ACEI/ARBs-exposed, 256 OAH-exposed and 495 NTE-exposed pregnancies were followed-up. The rate of major congenital anomalies was comparable between the groups (8/190, 4.2%, ACEI/ARB; 9/212, 4.2%, OAH; 18/471, 3.8% NTE; p = 0.954) among first trimester exposed pregnancies. The median gestational age at delivery was two weeks earlier, rate of preterm deliveries more than 2-fold higher, and median birth weight more than 200 g lower in the ACEI/ARB and OAH groups compared to the NTE group.

CONCLUSION

The present study suggests that ACEI/ARBs are not major teratogens when used in the first trimester, and can reassure women with similar exposures.

Authors+Show Affiliations

The Israeli Teratology Information Service, Jerusalem, Israel Ministry of Health, Jerusalem, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

21338666

Citation

Diav-Citrin, Orna, et al. "Pregnancy Outcome After in Utero Exposure to Angiotensin Converting Enzyme Inhibitors or Angiotensin Receptor Blockers." Reproductive Toxicology (Elmsford, N.Y.), vol. 31, no. 4, 2011, pp. 540-5.
Diav-Citrin O, Shechtman S, Halberstadt Y, et al. Pregnancy outcome after in utero exposure to angiotensin converting enzyme inhibitors or angiotensin receptor blockers. Reprod Toxicol. 2011;31(4):540-5.
Diav-Citrin, O., Shechtman, S., Halberstadt, Y., Finkel-Pekarsky, V., Wajnberg, R., Arnon, J., ... Ornoy, A. (2011). Pregnancy outcome after in utero exposure to angiotensin converting enzyme inhibitors or angiotensin receptor blockers. Reproductive Toxicology (Elmsford, N.Y.), 31(4), pp. 540-5. doi:10.1016/j.reprotox.2011.02.008.
Diav-Citrin O, et al. Pregnancy Outcome After in Utero Exposure to Angiotensin Converting Enzyme Inhibitors or Angiotensin Receptor Blockers. Reprod Toxicol. 2011;31(4):540-5. PubMed PMID: 21338666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy outcome after in utero exposure to angiotensin converting enzyme inhibitors or angiotensin receptor blockers. AU - Diav-Citrin,Orna, AU - Shechtman,Svetlana, AU - Halberstadt,Yehudit, AU - Finkel-Pekarsky,Victoriya, AU - Wajnberg,Rebecka, AU - Arnon,Judy, AU - Di Gianantonio,Elena, AU - Clementi,Maurizio, AU - Ornoy,Asher, Y1 - 2011/02/18/ PY - 2010/12/01/received PY - 2011/02/06/revised PY - 2011/02/14/accepted PY - 2011/2/23/entrez PY - 2011/2/23/pubmed PY - 2011/9/21/medline SP - 540 EP - 5 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod. Toxicol. VL - 31 IS - 4 N2 - OBJECTIVE: To examine first trimester safety of angiotensin-converting-enzyme-inhibitors (ACEIs) or angiotensin-receptor-blockers (ARBs). STUDY DESIGN: Prospective observational cohort regarding pregnancy ACEI/ARBs-exposure including contacts to two Teratology Information Services in Israel (1994-2007) and Italy (1990-2008), with two comparison groups: (1) exposed to other antihypertensives (OAH) (2) after non-teratogenic exposure (NTE) in similar time frames. RESULTS: 252 ACEI/ARBs-exposed, 256 OAH-exposed and 495 NTE-exposed pregnancies were followed-up. The rate of major congenital anomalies was comparable between the groups (8/190, 4.2%, ACEI/ARB; 9/212, 4.2%, OAH; 18/471, 3.8% NTE; p = 0.954) among first trimester exposed pregnancies. The median gestational age at delivery was two weeks earlier, rate of preterm deliveries more than 2-fold higher, and median birth weight more than 200 g lower in the ACEI/ARB and OAH groups compared to the NTE group. CONCLUSION: The present study suggests that ACEI/ARBs are not major teratogens when used in the first trimester, and can reassure women with similar exposures. SN - 1873-1708 UR - https://www.unboundmedicine.com/medline/citation/21338666/Pregnancy_outcome_after_in_utero_exposure_to_angiotensin_converting_enzyme_inhibitors_or_angiotensin_receptor_blockers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-6238(11)00060-8 DB - PRIME DP - Unbound Medicine ER -