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The use of topical phenytoin for healing of chronic venous ulcerations.

Abstract

BACKGROUND

Many topical agents have been used for promotion of healing of chronic venous ulcers. One such agent that has been tried is phenytoin. The effect of phenytoin on cutaneous healing has been suggested. This study was designed to evaluate the efficacy of topical phenytoin in healing of venous ulcerations.

METHODS

One hundred and four patients with chronic venous ulcers were recruited in this study. They were divided into study group and control group. The study group was 54 patients while control group was 50 patients. Patients in the study group were subjected to dressing of their ulcers with topical phenytoin once daily while patients in the control group were subjected to dressing with normal saline. All patients were followed up for eight weeks and assessed for their ulcer status and recorded as: complete healing, partial healing, no improvement or worsening of the condition.

RESULTS

By the end of the eight weeks, complete healing was evident in 35/54 of the patients (64.8%) in the study group and 26/50 of the patients (52%) in the control group. It was statistically significant (p = .04). The rate of reduction in the mean surface area of the ulcers was faster in the study group than control group. Minor side effects were reported among 4 patients (7.4%) of the study group in the form of burning sensation.

CONCLUSION

Topical phenytoin can be used to enhance healing of chronic venous ulcers in conjunction with the established treatment. It has favorable results and tolerable local side effects.

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  • Authors+Show Affiliations

    ,

    Department of General Surgery, Faculty of Medicine, Suez Canal University, Round Road, Ismailia 41522, Egypt. ehokkam@gmail.com

    , , ,

    Source

    MeSH

    Administration, Cutaneous
    Adult
    Chronic Disease
    Dermatologic Agents
    Drug Administration Schedule
    Female
    Humans
    Male
    Middle Aged
    Phenytoin
    Treatment Outcome
    Varicose Ulcer
    Wound Healing

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    21338720

    Citation

    Hokkam, Emad, et al. "The Use of Topical Phenytoin for Healing of Chronic Venous Ulcerations." International Journal of Surgery (London, England), vol. 9, no. 4, 2011, pp. 335-8.
    Hokkam E, El-Labban G, Shams M, et al. The use of topical phenytoin for healing of chronic venous ulcerations. Int J Surg. 2011;9(4):335-8.
    Hokkam, E., El-Labban, G., Shams, M., Rifaat, S., & El-Mezaien, M. (2011). The use of topical phenytoin for healing of chronic venous ulcerations. International Journal of Surgery (London, England), 9(4), pp. 335-8. doi:10.1016/j.ijsu.2011.02.007.
    Hokkam E, et al. The Use of Topical Phenytoin for Healing of Chronic Venous Ulcerations. Int J Surg. 2011;9(4):335-8. PubMed PMID: 21338720.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The use of topical phenytoin for healing of chronic venous ulcerations. AU - Hokkam,Emad, AU - El-Labban,Gouda, AU - Shams,Mohamed, AU - Rifaat,Sherif, AU - El-Mezaien,Mamdouh, Y1 - 2011/02/19/ PY - 2010/09/24/received PY - 2010/11/12/revised PY - 2011/02/14/accepted PY - 2011/2/23/entrez PY - 2011/2/23/pubmed PY - 2011/12/13/medline SP - 335 EP - 8 JF - International journal of surgery (London, England) JO - Int J Surg VL - 9 IS - 4 N2 - BACKGROUND: Many topical agents have been used for promotion of healing of chronic venous ulcers. One such agent that has been tried is phenytoin. The effect of phenytoin on cutaneous healing has been suggested. This study was designed to evaluate the efficacy of topical phenytoin in healing of venous ulcerations. METHODS: One hundred and four patients with chronic venous ulcers were recruited in this study. They were divided into study group and control group. The study group was 54 patients while control group was 50 patients. Patients in the study group were subjected to dressing of their ulcers with topical phenytoin once daily while patients in the control group were subjected to dressing with normal saline. All patients were followed up for eight weeks and assessed for their ulcer status and recorded as: complete healing, partial healing, no improvement or worsening of the condition. RESULTS: By the end of the eight weeks, complete healing was evident in 35/54 of the patients (64.8%) in the study group and 26/50 of the patients (52%) in the control group. It was statistically significant (p = .04). The rate of reduction in the mean surface area of the ulcers was faster in the study group than control group. Minor side effects were reported among 4 patients (7.4%) of the study group in the form of burning sensation. CONCLUSION: Topical phenytoin can be used to enhance healing of chronic venous ulcers in conjunction with the established treatment. It has favorable results and tolerable local side effects. SN - 1743-9159 UR - https://www.unboundmedicine.com/medline/citation/21338720/The_use_of_topical_phenytoin_for_healing_of_chronic_venous_ulcerations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-9191(11)00026-4 DB - PRIME DP - Unbound Medicine ER -