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The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.
Neurology. 2011 Feb 22; 76(8 Suppl 3):S9-14.Neur

Abstract

Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has recently been approved as the first oral treatment for relapsing forms of multiple sclerosis in some countries. Fingolimod has documented effects on lymphocyte egress, selectively retaining lymphocytes within the lymph nodes. In addition, fingolimod can enter the CNS and can act on S1PRs expressed by most neural lineages. In this article, we discuss recent results supporting the concept that S1PR modulators may exert neuroprotective and regenerative actions in the CNS as well as having anti-inflammatory effects.

Authors+Show Affiliations

Department of Neurology, University of Chicago, IL 60637, USA. bsoliven@neurology.bsd.uchicago.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21339490

Citation

Soliven, Betty, et al. "The Neurobiology of Sphingosine 1-phosphate Signaling and Sphingosine 1-phosphate Receptor Modulators." Neurology, vol. 76, no. 8 Suppl 3, 2011, pp. S9-14.
Soliven B, Miron V, Chun J. The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. Neurology. 2011;76(8 Suppl 3):S9-14.
Soliven, B., Miron, V., & Chun, J. (2011). The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. Neurology, 76(8 Suppl 3), S9-14. https://doi.org/10.1212/WNL.0b013e31820d9507
Soliven B, Miron V, Chun J. The Neurobiology of Sphingosine 1-phosphate Signaling and Sphingosine 1-phosphate Receptor Modulators. Neurology. 2011 Feb 22;76(8 Suppl 3):S9-14. PubMed PMID: 21339490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. AU - Soliven,Betty, AU - Miron,Veronique, AU - Chun,Jerold, PY - 2011/2/23/entrez PY - 2011/2/26/pubmed PY - 2011/3/12/medline SP - S9 EP - 14 JF - Neurology JO - Neurology VL - 76 IS - 8 Suppl 3 N2 - Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has recently been approved as the first oral treatment for relapsing forms of multiple sclerosis in some countries. Fingolimod has documented effects on lymphocyte egress, selectively retaining lymphocytes within the lymph nodes. In addition, fingolimod can enter the CNS and can act on S1PRs expressed by most neural lineages. In this article, we discuss recent results supporting the concept that S1PR modulators may exert neuroprotective and regenerative actions in the CNS as well as having anti-inflammatory effects. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/21339490/The_neurobiology_of_sphingosine_1_phosphate_signaling_and_sphingosine_1_phosphate_receptor_modulators_ DB - PRIME DP - Unbound Medicine ER -