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Anti-annexin V IgG and IgM antibodies in sickle cell disease patients with vaso-occlusive crisis.
Ann Hematol. 2011 Sep; 90(9):1031-6.AH

Abstract

Vaso-occlusive crisis (VOC) is a significant cause of morbidity and mortality in sickle cell anemia (SCA) patients; however, its mechanisms are poorly understood. In view of their prothrombotic nature, we hypothesized that SCA-associated VOC may be due to the presence of anti-annexin V antibodies. Anti-annexin V antibodies were measured with ELISA in 177 VOC and 81 steady-state SCA patients. Anti-annexin V IgM and IgG concentrations were significantly higher in VOC patients than in steady-state patients and were associated with elevated VOC risk. After categorizing anti-annexin V antibodies, the adjusted odds ratio increased as the percentile value increased. Monovariate logistic regression analysis demonstrated a positive dose-effect relationship for anti-annexin V IgM with VOC, with increased VOC risk seen with increased antibody titers. Multivariate logistic regression analyses confirmed the association of anti-annexin V IgM, more so than IgG, as an independent VOC risk factor. Anti-annexin V IgG antibodies correlated positively with VOC type and negatively with HbF and age of VOC onset, while anti-annexin V IgM correlated positively with VOC type, duration, frequency, site, pain severity, hospitalization, and medication, and negatively with age of VOC onset and HbS levels. High levels of anti-annexin V IgM antibodies constitute a risk factor for VOC in SCA patients.

Authors+Show Affiliations

Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21340721

Citation

Sater, Mai S., et al. "Anti-annexin V IgG and IgM Antibodies in Sickle Cell Disease Patients With Vaso-occlusive Crisis." Annals of Hematology, vol. 90, no. 9, 2011, pp. 1031-6.
Sater MS, Mahdi N, Al-Absi IK, et al. Anti-annexin V IgG and IgM antibodies in sickle cell disease patients with vaso-occlusive crisis. Ann Hematol. 2011;90(9):1031-6.
Sater, M. S., Mahdi, N., Al-Absi, I. K., Al-Subaie, A. M., Al-Ola, K., Mohammed, F. A., & Almawi, W. Y. (2011). Anti-annexin V IgG and IgM antibodies in sickle cell disease patients with vaso-occlusive crisis. Annals of Hematology, 90(9), 1031-6. https://doi.org/10.1007/s00277-011-1184-5
Sater MS, et al. Anti-annexin V IgG and IgM Antibodies in Sickle Cell Disease Patients With Vaso-occlusive Crisis. Ann Hematol. 2011;90(9):1031-6. PubMed PMID: 21340721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-annexin V IgG and IgM antibodies in sickle cell disease patients with vaso-occlusive crisis. AU - Sater,Mai S, AU - Mahdi,Najat, AU - Al-Absi,Iman K, AU - Al-Subaie,Abeer M, AU - Al-Ola,Khadija, AU - Mohammed,Fatema A, AU - Almawi,Wassim Y, Y1 - 2011/02/22/ PY - 2010/11/02/received PY - 2011/02/02/accepted PY - 2011/2/23/entrez PY - 2011/2/23/pubmed PY - 2011/10/1/medline SP - 1031 EP - 6 JF - Annals of hematology JO - Ann. Hematol. VL - 90 IS - 9 N2 - Vaso-occlusive crisis (VOC) is a significant cause of morbidity and mortality in sickle cell anemia (SCA) patients; however, its mechanisms are poorly understood. In view of their prothrombotic nature, we hypothesized that SCA-associated VOC may be due to the presence of anti-annexin V antibodies. Anti-annexin V antibodies were measured with ELISA in 177 VOC and 81 steady-state SCA patients. Anti-annexin V IgM and IgG concentrations were significantly higher in VOC patients than in steady-state patients and were associated with elevated VOC risk. After categorizing anti-annexin V antibodies, the adjusted odds ratio increased as the percentile value increased. Monovariate logistic regression analysis demonstrated a positive dose-effect relationship for anti-annexin V IgM with VOC, with increased VOC risk seen with increased antibody titers. Multivariate logistic regression analyses confirmed the association of anti-annexin V IgM, more so than IgG, as an independent VOC risk factor. Anti-annexin V IgG antibodies correlated positively with VOC type and negatively with HbF and age of VOC onset, while anti-annexin V IgM correlated positively with VOC type, duration, frequency, site, pain severity, hospitalization, and medication, and negatively with age of VOC onset and HbS levels. High levels of anti-annexin V IgM antibodies constitute a risk factor for VOC in SCA patients. SN - 1432-0584 UR - https://www.unboundmedicine.com/medline/citation/21340721/Anti_annexin_V_IgG_and_IgM_antibodies_in_sickle_cell_disease_patients_with_vaso_occlusive_crisis_ L2 - https://dx.doi.org/10.1007/s00277-011-1184-5 DB - PRIME DP - Unbound Medicine ER -