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Cephalometric features in isolated growth hormone deficiency.
Angle Orthod. 2011 Jul; 81(4):578-83.AO

Abstract

OBJECTIVE

To analyze cephalometric features in adults with isolated growth hormone (GH) deficiency (IGHD).

MATERIALS AND METHODS

Nine adult IGHD individuals (7 males and 2 females; mean age, 37.8 ± 13.8 years) underwent a cross-sectional cephalometric study, including 9 linear and 5 angular measurements. Posterior facial height/anterior facial height and lower-anterior facial height/anterior facial height ratios were calculated. To pool cephalometric measurements in both genders, results were normalized by standard deviation scores (SDS), using the population means from an atlas of the normal Brazilian population.

RESULTS

All linear measurements were reduced in IGHD subjects. Total maxillary length was the most reduced parameter (-6.5 ± 1.7), followed by a cluster of six measurements: posterior cranial base length (-4.9 ± 1.1), total mandibular length (-4.4 ± 0.7), total posterior facial height (-4.4 ± 1.1), total anterior facial height (-4.3 ± 0.9), mandibular corpus length (-4.2 ± 0.8), and anterior cranial base length (-4.1 ± 1.7). Less affected measurements were lower-anterior facial height (-2.7 ± 0.7) and mandibular ramus height (-2.5 ± 1.5). SDS angular measurements were in the normal range, except for increased gonial angle (+2.5 ± 1.1). Posterior facial height/anterior facial height and lower-anterior facial height/anterior facial height ratios were not different from those of the reference group.

CONCLUSIONS

Congenital, untreated IGHD causes reduction of all linear measurements of craniofacial growth, particularly total maxillary length. Angular measurements and facial height ratios are less affected, suggesting that lGHD causes proportional blunting of craniofacial growth.

Authors+Show Affiliations

Department of Orthodontics, School of Dentistry, Federal University of Sergipe, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21341997

Citation

Oliveira-Neto, Luiz Alves, et al. "Cephalometric Features in Isolated Growth Hormone Deficiency." The Angle Orthodontist, vol. 81, no. 4, 2011, pp. 578-83.
Oliveira-Neto LA, Melo Mde F, Franco AA, et al. Cephalometric features in isolated growth hormone deficiency. Angle Orthod. 2011;81(4):578-83.
Oliveira-Neto, L. A., Melo, M. d. e. . F., Franco, A. A., Oliveira, A. H., Souza, A. H., Valença, E. H., Britto, I. M., Salvatori, R., & Aguiar-Oliveira, M. H. (2011). Cephalometric features in isolated growth hormone deficiency. The Angle Orthodontist, 81(4), 578-83. https://doi.org/10.2319/102210-618.1
Oliveira-Neto LA, et al. Cephalometric Features in Isolated Growth Hormone Deficiency. Angle Orthod. 2011;81(4):578-83. PubMed PMID: 21341997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cephalometric features in isolated growth hormone deficiency. AU - Oliveira-Neto,Luiz Alves, AU - Melo,Mariade de Fátima B, AU - Franco,Alexandre A, AU - Oliveira,Alaíde H A, AU - Souza,Anita H O, AU - Valença,Eugênia H O, AU - Britto,Isabela M P A, AU - Salvatori,Roberto, AU - Aguiar-Oliveira,Manuel H, Y1 - 2011/02/21/ PY - 2011/2/24/entrez PY - 2011/2/24/pubmed PY - 2011/11/8/medline SP - 578 EP - 83 JF - The Angle orthodontist JO - Angle Orthod VL - 81 IS - 4 N2 - OBJECTIVE: To analyze cephalometric features in adults with isolated growth hormone (GH) deficiency (IGHD). MATERIALS AND METHODS: Nine adult IGHD individuals (7 males and 2 females; mean age, 37.8 ± 13.8 years) underwent a cross-sectional cephalometric study, including 9 linear and 5 angular measurements. Posterior facial height/anterior facial height and lower-anterior facial height/anterior facial height ratios were calculated. To pool cephalometric measurements in both genders, results were normalized by standard deviation scores (SDS), using the population means from an atlas of the normal Brazilian population. RESULTS: All linear measurements were reduced in IGHD subjects. Total maxillary length was the most reduced parameter (-6.5 ± 1.7), followed by a cluster of six measurements: posterior cranial base length (-4.9 ± 1.1), total mandibular length (-4.4 ± 0.7), total posterior facial height (-4.4 ± 1.1), total anterior facial height (-4.3 ± 0.9), mandibular corpus length (-4.2 ± 0.8), and anterior cranial base length (-4.1 ± 1.7). Less affected measurements were lower-anterior facial height (-2.7 ± 0.7) and mandibular ramus height (-2.5 ± 1.5). SDS angular measurements were in the normal range, except for increased gonial angle (+2.5 ± 1.1). Posterior facial height/anterior facial height and lower-anterior facial height/anterior facial height ratios were not different from those of the reference group. CONCLUSIONS: Congenital, untreated IGHD causes reduction of all linear measurements of craniofacial growth, particularly total maxillary length. Angular measurements and facial height ratios are less affected, suggesting that lGHD causes proportional blunting of craniofacial growth. SN - 1945-7103 UR - https://www.unboundmedicine.com/medline/citation/21341997/Cephalometric_features_in_isolated_growth_hormone_deficiency_ L2 - https://meridian.allenpress.com/angle-orthodontist/article-lookup/doi/10.2319/102210-618.1 DB - PRIME DP - Unbound Medicine ER -