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Serial intervals and the temporal distribution of secondary infections within households of 2009 pandemic influenza A (H1N1): implications for influenza control recommendations.
Clin Infect Dis. 2011 Jan 01; 52 Suppl 1:S123-30.CI

Abstract

A critical issue during the 2009 influenza A (H1N1) pandemic was determining the appropriate duration of time individuals with influenza-like illness (ILI) should remain isolated to reduce onward transmission while limiting societal disruption. Ideally this is based on knowledge of the relative infectiousness of ill individuals at each point during the course of the infection. Data on 261 clinically apparent pH1N1 infector-infectee pairs in households, from 7 epidemiological studies conducted in the United States early in 2009, were analyzed to estimate the distribution of times from symptom onset in an infector to symptom onset in the household contacts they infect (mean, 2.9 days, not correcting for tertiary transmission). Only 5% of transmission events were estimated to take place >3 days after the onset of clinical symptoms among those ill with pH1N1 virus. These results will inform future recommendations on duration of isolation of individuals with ILI.

Authors+Show Affiliations

Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom. c.donnelly@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

21342883

Citation

Donnelly, Christl A., et al. "Serial Intervals and the Temporal Distribution of Secondary Infections Within Households of 2009 Pandemic Influenza a (H1N1): Implications for Influenza Control Recommendations." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 52 Suppl 1, 2011, pp. S123-30.
Donnelly CA, Finelli L, Cauchemez S, et al. Serial intervals and the temporal distribution of secondary infections within households of 2009 pandemic influenza A (H1N1): implications for influenza control recommendations. Clin Infect Dis. 2011;52 Suppl 1:S123-30.
Donnelly, C. A., Finelli, L., Cauchemez, S., Olsen, S. J., Doshi, S., Jackson, M. L., Kennedy, E. D., Kamimoto, L., Marchbanks, T. L., Morgan, O. W., Patel, M., Swerdlow, D. L., & Ferguson, N. M. (2011). Serial intervals and the temporal distribution of secondary infections within households of 2009 pandemic influenza A (H1N1): implications for influenza control recommendations. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 52 Suppl 1, S123-30. https://doi.org/10.1093/cid/ciq028
Donnelly CA, et al. Serial Intervals and the Temporal Distribution of Secondary Infections Within Households of 2009 Pandemic Influenza a (H1N1): Implications for Influenza Control Recommendations. Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S123-30. PubMed PMID: 21342883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serial intervals and the temporal distribution of secondary infections within households of 2009 pandemic influenza A (H1N1): implications for influenza control recommendations. AU - Donnelly,Christl A, AU - Finelli,Lyn, AU - Cauchemez,Simon, AU - Olsen,Sonja J, AU - Doshi,Saumil, AU - Jackson,Michael L, AU - Kennedy,Erin D, AU - Kamimoto,Laurie, AU - Marchbanks,Tiffany L, AU - Morgan,Oliver W, AU - Patel,Minal, AU - Swerdlow,David L, AU - Ferguson,Neil M, AU - ,, PY - 2011/2/24/entrez PY - 2011/3/8/pubmed PY - 2011/5/14/medline SP - S123 EP - 30 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 52 Suppl 1 N2 - A critical issue during the 2009 influenza A (H1N1) pandemic was determining the appropriate duration of time individuals with influenza-like illness (ILI) should remain isolated to reduce onward transmission while limiting societal disruption. Ideally this is based on knowledge of the relative infectiousness of ill individuals at each point during the course of the infection. Data on 261 clinically apparent pH1N1 infector-infectee pairs in households, from 7 epidemiological studies conducted in the United States early in 2009, were analyzed to estimate the distribution of times from symptom onset in an infector to symptom onset in the household contacts they infect (mean, 2.9 days, not correcting for tertiary transmission). Only 5% of transmission events were estimated to take place >3 days after the onset of clinical symptoms among those ill with pH1N1 virus. These results will inform future recommendations on duration of isolation of individuals with ILI. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/21342883/full_citation L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/ciq028 DB - PRIME DP - Unbound Medicine ER -