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Hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in the United States--September-October 2009.
Clin Infect Dis 2011; 52 Suppl 1:S50-9CI

Abstract

Given the potential worsening clinical severity of 2009 pandemic influenza A (H1N1) virus (pH1N1) infection from spring to fall 2009, we conducted a clinical case series among patients hospitalized with pH1N1 infection from September through October 2009. A case patient was defined as a hospitalized person who had test results positive for pH1N1 virus by real-time reverse-transcription polymerase chain reaction. Among 255 hospitalized patients, 34% were admitted to an intensive care unit and 8% died. Thirty-four percent of patients were children <18 years of age, 8% were adults ≥ 65 years of age, and 67% had an underlying medical condition. Chest radiographs obtained at hospital admission that had findings that were consistent with pneumonia were noted in 103 (46%) of 255 patients. Among 255 hospitalized patients, 208 (82%) received neuraminidase inhibitors, but only 47% had treatment started ≤ 2 days after illness onset. Overall, characteristics of hospitalized patients with pH1N1 infection in fall 2009 were similar to characteristics of patients hospitalized with pH1N1 infection in spring 2009, which suggests that clinical severity did not change substantially over this period.

Authors+Show Affiliations

Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

21342900

Citation

Skarbinski, Jacek, et al. "Hospitalized Patients With 2009 Pandemic Influenza a (H1N1) Virus Infection in the United States--September-October 2009." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 52 Suppl 1, 2011, pp. S50-9.
Skarbinski J, Jain S, Bramley A, et al. Hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in the United States--September-October 2009. Clin Infect Dis. 2011;52 Suppl 1:S50-9.
Skarbinski, J., Jain, S., Bramley, A., Lee, E. J., Huang, J., Kirschke, D., ... Finelli, L. (2011). Hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in the United States--September-October 2009. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 52 Suppl 1, pp. S50-9. doi:10.1093/cid/ciq021.
Skarbinski J, et al. Hospitalized Patients With 2009 Pandemic Influenza a (H1N1) Virus Infection in the United States--September-October 2009. Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S50-9. PubMed PMID: 21342900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in the United States--September-October 2009. AU - Skarbinski,Jacek, AU - Jain,Seema, AU - Bramley,Anna, AU - Lee,Esther J, AU - Huang,Jean, AU - Kirschke,David, AU - Stone,Allison, AU - Wedlake,Tiffany, AU - Richards,Shawn M, AU - Page,Shannon, AU - Ragan,Patti, AU - Bullion,Lesley, AU - Neises,Daniel, AU - Williams,Robin M, AU - Petruccelli,Bruno P, AU - Vandermeer,Meredith, AU - Lofy,Kathryn H, AU - Gindler,Jacqueline, AU - Finelli,Lyn, AU - ,, PY - 2011/2/24/entrez PY - 2011/3/8/pubmed PY - 2011/5/14/medline SP - S50 EP - 9 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 52 Suppl 1 N2 - Given the potential worsening clinical severity of 2009 pandemic influenza A (H1N1) virus (pH1N1) infection from spring to fall 2009, we conducted a clinical case series among patients hospitalized with pH1N1 infection from September through October 2009. A case patient was defined as a hospitalized person who had test results positive for pH1N1 virus by real-time reverse-transcription polymerase chain reaction. Among 255 hospitalized patients, 34% were admitted to an intensive care unit and 8% died. Thirty-four percent of patients were children <18 years of age, 8% were adults ≥ 65 years of age, and 67% had an underlying medical condition. Chest radiographs obtained at hospital admission that had findings that were consistent with pneumonia were noted in 103 (46%) of 255 patients. Among 255 hospitalized patients, 208 (82%) received neuraminidase inhibitors, but only 47% had treatment started ≤ 2 days after illness onset. Overall, characteristics of hospitalized patients with pH1N1 infection in fall 2009 were similar to characteristics of patients hospitalized with pH1N1 infection in spring 2009, which suggests that clinical severity did not change substantially over this period. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/21342900/Hospitalized_patients_with_2009_pandemic_influenza_A__H1N1__virus_infection_in_the_United_States__September_October_2009_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/ciq021 DB - PRIME DP - Unbound Medicine ER -