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Multicenter study in Taiwan of the in vitro activities of nemonoxacin, tigecycline, doripenem, and other antimicrobial agents against clinical isolates of various Nocardia species.
Antimicrob Agents Chemother. 2011 May; 55(5):2084-91.AA

Abstract

The aim of this study was to assess the in vitro activities of nemonoxacin (a novel nonfluorinated quinolone), doripenem, tigecycline, and 16 other antimicrobial agents against Nocardia species. The MICs of the 19 agents against 151 clinical isolates of Nocardia species were determined by the broth microdilution method. The isolates were identified to the species level using 16S rRNA gene sequencing analysis. The results showed that N. brasiliensis (n=60; 40%) was the most common species, followed by N. cyriacigeorgica (n=24; 16%), N. farcinica (n=12; 8%), N. beijingensis (n=9), N. otitidiscaviarum (n=8), N. nova (n=8), N. asiatica (n=7), N. puris (n=6), N. flavorosea (n=5), N. abscessus (n=3), N. carnea (2), and one each of N. alba, N. asteroides complex, N. rhamnosiphila, N. elegans, N. jinanensis, N. takedensis, and N. transvalensis. The MIC90s of the tested quinolones against the N. brasiliensis isolates were in the order nemonoxacin=gemifloxacin<moxifloxacin<levofloxacin=ciprofloxacin, and the MIC90s of the tested carbapenems were in the order doripenem=meropenem<ertapenem<imipenem. Tigecycline had a lower MIC90 (1 μg/ml) than linezolid (8 μg/ml). The MIC90s of the tested quinolones against N. cyriacigeorgica isolates were in the order nemonoxacin<gemifloxacin<moxifloxacin<levofloxacin<ciprofloxacin, and the MIC90s of the tested carbapenems were in the order imipenem<doripenem=meropenem<ertapenem. Nemonoxacin had the lowest MIC90 values among the tested quinolones against the other 17 Nocardia isolates. Among the four tested carbapenems, imipenem had the lowest MIC90s. All of the clinical isolates of N. beijingensis, N. otitidiscaviarum, N. nova, and N. puris and more than half of the N. brasiliensis and N. cyriacigeorgica isolates were resistant to at least one antimicrobial agent. The results of this in vitro study suggest that nemonoxacin, linezolid, and tigecycline are promising treatment options for nocardiosis. Further investigation of their clinical role is warranted.

Authors+Show Affiliations

Department of Intensive Care Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21343461

Citation

Lai, Chih-Cheng, et al. "Multicenter Study in Taiwan of the in Vitro Activities of Nemonoxacin, Tigecycline, Doripenem, and Other Antimicrobial Agents Against Clinical Isolates of Various Nocardia Species." Antimicrobial Agents and Chemotherapy, vol. 55, no. 5, 2011, pp. 2084-91.
Lai CC, Liu WL, Ko WC, et al. Multicenter study in Taiwan of the in vitro activities of nemonoxacin, tigecycline, doripenem, and other antimicrobial agents against clinical isolates of various Nocardia species. Antimicrob Agents Chemother. 2011;55(5):2084-91.
Lai, C. C., Liu, W. L., Ko, W. C., Chen, Y. H., Tan, H. R., Huang, Y. T., & Hsueh, P. R. (2011). Multicenter study in Taiwan of the in vitro activities of nemonoxacin, tigecycline, doripenem, and other antimicrobial agents against clinical isolates of various Nocardia species. Antimicrobial Agents and Chemotherapy, 55(5), 2084-91. https://doi.org/10.1128/AAC.01808-10
Lai CC, et al. Multicenter Study in Taiwan of the in Vitro Activities of Nemonoxacin, Tigecycline, Doripenem, and Other Antimicrobial Agents Against Clinical Isolates of Various Nocardia Species. Antimicrob Agents Chemother. 2011;55(5):2084-91. PubMed PMID: 21343461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multicenter study in Taiwan of the in vitro activities of nemonoxacin, tigecycline, doripenem, and other antimicrobial agents against clinical isolates of various Nocardia species. AU - Lai,Chih-Cheng, AU - Liu,Wei-Lun, AU - Ko,Wen-Chien, AU - Chen,Yen-Hsu, AU - Tan,Hon-Ren, AU - Huang,Yu-Tsung, AU - Hsueh,Po-Ren, Y1 - 2011/02/22/ PY - 2011/2/24/entrez PY - 2011/2/24/pubmed PY - 2011/10/5/medline SP - 2084 EP - 91 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 55 IS - 5 N2 - The aim of this study was to assess the in vitro activities of nemonoxacin (a novel nonfluorinated quinolone), doripenem, tigecycline, and 16 other antimicrobial agents against Nocardia species. The MICs of the 19 agents against 151 clinical isolates of Nocardia species were determined by the broth microdilution method. The isolates were identified to the species level using 16S rRNA gene sequencing analysis. The results showed that N. brasiliensis (n=60; 40%) was the most common species, followed by N. cyriacigeorgica (n=24; 16%), N. farcinica (n=12; 8%), N. beijingensis (n=9), N. otitidiscaviarum (n=8), N. nova (n=8), N. asiatica (n=7), N. puris (n=6), N. flavorosea (n=5), N. abscessus (n=3), N. carnea (2), and one each of N. alba, N. asteroides complex, N. rhamnosiphila, N. elegans, N. jinanensis, N. takedensis, and N. transvalensis. The MIC90s of the tested quinolones against the N. brasiliensis isolates were in the order nemonoxacin=gemifloxacin<moxifloxacin<levofloxacin=ciprofloxacin, and the MIC90s of the tested carbapenems were in the order doripenem=meropenem<ertapenem<imipenem. Tigecycline had a lower MIC90 (1 μg/ml) than linezolid (8 μg/ml). The MIC90s of the tested quinolones against N. cyriacigeorgica isolates were in the order nemonoxacin<gemifloxacin<moxifloxacin<levofloxacin<ciprofloxacin, and the MIC90s of the tested carbapenems were in the order imipenem<doripenem=meropenem<ertapenem. Nemonoxacin had the lowest MIC90 values among the tested quinolones against the other 17 Nocardia isolates. Among the four tested carbapenems, imipenem had the lowest MIC90s. All of the clinical isolates of N. beijingensis, N. otitidiscaviarum, N. nova, and N. puris and more than half of the N. brasiliensis and N. cyriacigeorgica isolates were resistant to at least one antimicrobial agent. The results of this in vitro study suggest that nemonoxacin, linezolid, and tigecycline are promising treatment options for nocardiosis. Further investigation of their clinical role is warranted. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/21343461/Multicenter_study_in_Taiwan_of_the_in_vitro_activities_of_nemonoxacin_tigecycline_doripenem_and_other_antimicrobial_agents_against_clinical_isolates_of_various_Nocardia_species_ L2 - https://journals.asm.org/doi/10.1128/AAC.01808-10?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -